An Excess of Topical Calcium and Magnesium Reverses the Therapeutic Effect of Citrate on the Development of Corneal Ulcers After Alkali Injury

Cornea ◽  
1996 ◽  
Vol 15 (2) ◽  
pp. 191-195 ◽  
Author(s):  
Jeffrey L. Haddox ◽  
Roswell R. Pfister ◽  
Suzanne E. Slaughter
Keyword(s):  
Therapeutic Effect ◽  
Corneal Ulcers ◽  
Alkali Injury ◽  
Calcium And Magnesium

scholarly journals Using ultraviolet corneal crosslinking for the treatment of corneal ulcers and other corneal pathologies in animals

2019 ◽  
Vol 12 (3) ◽  
pp. 51-57 ◽  
Author(s):  
E. N. Iomdina ◽  
L. F. Sotnikova ◽  
A. V. Goncharova ◽  
E. I. Kabanova ◽  
A. V. Chechneva ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Radiation Power ◽  
Anterior Segment ◽  
Production Test ◽  
Corneal Ulcers ◽  
Output Wavelength ◽  
Uva Irradiation ◽  
Tear Production ◽  
Stratified Squamous Epithelium ◽  
Corneal Staphyloma

Purpose. To study the effects of corneal collagen cross-linking (CCL) using ultraviolet-A (UVA) irradiation with riboflavin on the eye’s anterior segment structures in corneal ulcers and other keratopathies in animals.Material and methods. The study involved 26 animals (39 eyes) — 10 cats, 10 dogs, and 6 horses with ulcers, corneal staphyloma, dry and autoimmune keratoconjunctivitis. Examination included slit-lamp biomicroscopy, ophthalmoscopy (in cases of transparent cornea), tear production test, and staining the eye surface with vital dyes. CCL was performed using UVA radiation of LEDs with a fiber optic output (wavelength 370 nm, radiation power 3 mW/cm2) combined with 0.1 % riboflavin instillation according to the protocol we developed, which specifies various numbers and durations depending on the diagnosis and therapeutic effect desired.Results. Restoration of the shape and transparency of the cornea, relief of anterior eye inflammation, and normalization of tear production occurred much sooner than using traditional treatment. The restoration of vision occurred 2 to 3 months earlier in eyes with corneal staphyloma; more than 4 to 5 months earlier in eyes with keratoconjunctivitis; no relapses were noted in eyes with ulcerative processes, and the restoration of the function of stratified squamous epithelium was achieved within 2 or 3 weeks.Conclusions. The inclusion of modified UFA-based CCL in the treatment scheme of corneal ulcers and staphylomas as well as dry and autoimmune keratoconjunctivitis enables a high therapeutic effect of anterior eye structure restoration. In future, the results obtained could serve as basis for using the developed technology in the treatment of similar eye pathologies in humans. 

Therapeutic Effect of Culture and Antibiogram in Bacterial Corneal Ulcers

2005 ◽  
Vol 37 (3) ◽  
pp. 191-194
Author(s):  
Ihsan Çaça ◽  
Kaan Ünlü ◽  
Seyhmus Ari ◽  
Yildirim Bayezit Sakalar
Keyword(s):  
Therapeutic Effect ◽  
Corneal Ulcers

Improvement of SSPE after carbamazepine: natural course or therapeutic effect?

2010 ◽  
Vol 41 (02) ◽  
Author(s):  
M Schimmel ◽  
J Penzien
Keyword(s):  
Therapeutic Effect ◽  
Natural Course

Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis

1994 ◽  
Vol 71 (06) ◽  
pp. 768-772 ◽  
Author(s):  
Gerhard Dickneite ◽  
Jörg Czech
Keyword(s):  
Septic Shock ◽  
Klebsiella Pneumoniae ◽  
Organ Failure ◽  
Therapeutic Effect ◽  
Disseminated Intravascular Coagulation ◽  
Post Infection ◽  
Thrombin Inhibitor ◽  
Bolus Administration ◽  
Bacterial Burden ◽  
Recombinant Hirudin

SummaryRats which were infected with the gramnegative pathogen Klebsiella pneumoniae develop disseminated intravascular coagulation (DIC), multi-organ failure (MOF) and finally die in a septic shock. We investigated the therapeutic effect of antibiotic (tobramycin) treatment combined with the infusion of the highly specific thrombin inhibitor rec. hirudin. Although administration of 2 mg/kg tobramycin alone leads to a decrease of the bacterial burden, DIC could not be prevented. Infusion of rec. hirudin (0.25 mg/kg x h) for 4 h (start of treatment 1 h post infection), in addition to a bolus administration of tobramycin, led to an amelioration of DIC parameters as fibrinogen, thrombin-antithrombin complex (TAT) and platelets. Serum transaminase levels (GOT, GPT) as a marker of MOF were significantly improved by rec. hirudin, the T50 value increased from 17 h in the tobramycin group to 42 h in the tobramycin + rec. hirudin giuup, muilality rates were 90% or 60%, respectively. Combination of heparin (10011/kg x h) and tobramycin was not effective on survival.

The Effect of Calcium and Magnesium on Rabbit Blood Platelet Aggregation in Vitro

1964 ◽  
Vol 12 (01) ◽  
pp. 179-200 ◽  
Author(s):  
Torstein Hovig
Keyword(s):  
Platelet Aggregation ◽  
Cation Exchange ◽  
Calcium Concentration ◽  
Blood Platelets ◽  
Blood Platelet ◽  
Rabbit Blood ◽  
Calcium And Magnesium ◽  
Induced Aggregation ◽  
Blood Platelet Aggregation

SummaryThe effect of calcium and magnesium on the aggregation of rabbit blood platelets in vitro was studied, with the following results:1. Platelet aggregation induced by ADP or collagen could be prevented by EGTA or EDTA. The aggregating effect was restored by recalcification. The effect was also restored by addition of magnesium in EDTA-PRP, but not in EGTA-PRP unless a surplus of calcium was present.2. Calcium remained in concentrations of the order of 0.15–0.25 mM after dialysis or cation exchange of plasma. Aggregation of washed platelets resuspended in such plasma could not be produced with ADP or collagen, unless the calcium concentration was increased or that magnesium was added.3. The adhesiveness of blood platelets to collagen was reduced in EGTA-PRP and EDTA-PRP. Release of ADP from platelets influenced by collagen could not be demonstrated either in EGTA-PRP (presence of magnesium) or in EDTA-PRP.4. It is concluded that calcium is a necessary factor both for the reaction leading to release of ADP and for the the aggregation produced by ADP.5. Thrombin induced aggregation of washed platelets suspended in tris-buffered saline in the presence of calcium. No effect of magnesium could be observed unless small quantities of calcium were present.

The Risk Factor Analysis of Infectious Corneal Ulcers Leading to Eyeball Removal

2008 ◽  
Vol 49 (1) ◽  
pp. 34 ◽  
Author(s):  
Sang Hyun Cho ◽  
Joo Wan Park ◽  
Sung Kun Chung
Keyword(s):  
Factor Analysis ◽  
Risk Factor ◽  
Risk Factor Analysis ◽  
Corneal Ulcers

Therapeutic effect of 60-Co teletherapy and radium treatment to various malignant neoplasm

1970 ◽  
Vol 6 (1) ◽  
pp. 1 ◽  
Author(s):  
JY Kim ◽  
JW Chung ◽  
SS Park
Keyword(s):  
Therapeutic Effect ◽  
Malignant Neoplasm ◽  
Radium Treatment

MR imaging of intracranial tuberculosis: Emphasis on development of lesions and therapeutic effect

1993 ◽  
Vol 29 (6) ◽  
pp. 1121
Author(s):  
Kook Sang Han ◽  
Chang Hyo Sol ◽  
Young Joon Lee ◽  
Chang Ho Choi ◽  
Sang Ook Kim ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Therapeutic Effect
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