Carotid Intima-Media Thickness as a Cardiovascular Risk Marker in Pediatric End-Stage Renal Disease Patients on Dialysis and in Renal Transplantation

2008 ◽  
Vol 40 (9) ◽  
pp. 3244-3246 ◽  
Author(s):  
A. Delucchi ◽  
H. Dinamarca ◽  
H. Gainza ◽  
C. Whitttle ◽  
I. Torrealba ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Renal Transplantation ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Risk Marker ◽  
Stage Renal Disease ◽  
End Stage ◽  
Cardiovascular Risk Marker

Abstract P218: Carotid Intima-media Thickness and Incident End-stage Renal Disease: The Atherosclerosis Risk in Communities Study

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Yuanjie Pang ◽  
Yingying Sang ◽  
Shoshana Ballew ◽  
Morgan Grams ◽  
Gerardo Heiss ◽  
...  
Keyword(s):  
Renal Disease ◽  
Kidney Function ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Carotid Imt ◽  
Media Thickness ◽  
Hazard Ratios ◽  
Stage Renal Disease ◽  
End Stage

Introduction: Carotid intima-media thickness (IMT) has been reported to predict kidney function decline. However, whether carotid IMT is associated with a hard kidney endpoint, end-stage renal disease (ESRD), has not been investigated. Hypothesis: We assessed the hypothesis that increased carotid IMT is associated with ESRD risk. Methods: We studied 13,197 ARIC participants at visit 1 (1987-1989) without history of cardiovascular disease including coronary heart disease, stroke and heart failure and assessed whether carotid IMT measured by B-mode ultrasound is associated with ESRD risk using Cox proportional-hazards models. Regarding carotid IMT parameters, we investigated the mean and maximum values of overall and segment-specific (common, bifurcation and internal carotid arteries) measurements. Results: Mean age was 54.0 (SD 5.7) years, and there were 3,373 (25.6%) blacks and 7,370 (55.8%) women. During a median follow-up of 22.7 years, 433 participants developed ESRD (1.4/1,000 person-years). After adjusting for shared risk factors for atherosclerosis and kidney disease, including baseline kidney function, carotid IMT was significantly associated with ESRD risk (hazard ratios between quartiles 4 and 1, 1.43 [95%CI: 1.01-2.04] for overall mean IMT and 1.73 [95%CI: 1.22-2.44] for overall maximum IMT). The associations were largely consistent in demographic and clinical subgroups. When we explored segment-specific IMTs, the associations with ESRD were most robust for bifurcation carotid. The adjusted hazard ratios between quartiles 4 and 1 were 1.48 (95%CI: 1.04-2.11) for mean bifurcation IMT and 1.42 (95%CI: 0.99-2.03) for maximum bifurcation IMT. Conclusions: Carotid IMT was independently associated with incident ESRD in the general population. Our findings suggest the shared etiology between atherosclerosis and ESRD and highlight the importance of monitoring kidney function over time in individuals with subclinical atherosclerosis.

scholarly journals Dialysis Methods May Affect Carotid Intima–Media Thickness in Chinese End-Stage Renal Disease Patients

Renal Failure ◽  
2012 ◽  
Vol 34 (10) ◽  
pp. 1206-1211 ◽  
Author(s):  
Zhanqin Shi ◽  
Ming Zhu ◽  
Jianming Guan ◽  
Jianghua Chen ◽  
Qiang He ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Stage Renal Disease ◽  
End Stage

Carotid intima–media thickness in children with end-stage renal disease on hemodialysis

2016 ◽  
Vol 29 (2) ◽  
pp. 280
Author(s):  
ZeinA Saber Omar ◽  
AliM Elshafie ◽  
MohammedH Bahbah ◽  
FathiaM Elnemr ◽  
SehamM Ragab
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Stage Renal Disease ◽  
End Stage

Serum Resistin, Adenylate Cyclase-Associated Protein 1 Gene Expression, and Carotid Intima-Media Thickness in Patients with End-Stage Renal Disease and Healthy Controls

2019 ◽  
Vol 10 (1) ◽  
pp. 51-60 ◽  
Author(s):  
Jelena Munjas ◽  
Miron Sopić ◽  
Nataša Bogavac-Stanojević ◽  
Milica Kravljača ◽  
Milica Miljković ◽  
...  
Keyword(s):  
Gene Expression ◽  
Renal Disease ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Healthy Controls ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
Resistin Mrna

Background: Human resistin is a proinflammatory cytokine with significant proatherogenic effects which acts through adenylyl cyclase-associated protein 1 (CAP1). Chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients have increased cardiovascular risk and resistin levels. Previous studies indicated resistin significance as a predictor of mortality in CKD. Aims: We sought to investigate plasma resistin levels, peripheral blood mononuclear cell (PBMC) resistin mRNA, and for the first time CAP1 mRNA levels in ESRD patients and healthy controls. We also sought to investigate the relation of resistin and CAP1 to carotid intima media thickness (CIMT), CD36 gene expression, and matrix metalloproteinase 9 (MMP-9) circulating levels in ESRD patients and healthy controls. Methods: This study included 33 patients with ESRD and 27 healthy controls. Resistin and MMP-9 levels were measured by ELISA. Resistin, CAP1, and CD36 PBMC mRNA were measured by quantitative PCR. Results: Our study showed that ESRD patients have significantly higher levels of circulatory resistin compared to healthy controls (p < 0.001), while there was no significant difference in resistin mRNA. A significant upregulation of CAP1 and CD36 was observed in the ESRD group (p < 0.001; p < 0.001). Resistin concentration correlated with CIMT in healthy controls (r = 0.512, p = 0.036), and with MMP-9 concentration in ESRD (r = 0.353, p = 0.044) and healthy controls (r = 0.463, p = 0.026). CAP1 correlated positively with CIMT (r = 0.464, p = 0.008) in ESRD, and with CD36 in healthy controls (r = 0.447, p = 0.022) and ESRD (r = 0.824, p < 0.001). Conclusion: The obtained data suggest that high levels of circulating resistin acting upon cells with an upregulated CAP1 gene could contribute to the increased inflammation and accelerated atherosclerosis seen in CKD patients.

Carotid intima media thickness and left ventricular changes in children with end-stage renal disease

2002 ◽  
Vol 34 (6) ◽  
pp. 2073-2075 ◽  
Author(s):  
A. Saygılı ◽  
Ö.. Barutçu ◽  
N. Cengiz ◽  
N.Ç.. Tarhan ◽  
A. Pourbagher ◽  
...  
Keyword(s):  
Renal Disease ◽  
End Stage Renal Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Left Ventricular ◽  
Media Thickness ◽  
Stage Renal Disease ◽  
End Stage
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