Metachronous Pulmonary Neoplasms in Lung Transplantation—When They Arise in the Donor Lung: A Case Report

2018 ◽  
Vol 50 (10) ◽  
pp. 4075-4079
Author(s):  
D. Rodrigues ◽  
J.M. Borro ◽  
J. Amado ◽  
A.P. Vaz
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Haruchika Yamamoto ◽  
Kentaroh Miyoshi ◽  
Shinji Otani ◽  
Takeshi Kurosaki ◽  
Seiichiro Sugimoto ◽  
...  

2014 ◽  
Vol 53 (15) ◽  
pp. 1645-1650
Author(s):  
Hiroshi Yamamoto ◽  
Kazuo Yoshida ◽  
Tomonobu Koizumi ◽  
Yayoi Tokoro ◽  
Toshiro Fukushima ◽  
...  

2021 ◽  
Vol 40 (4) ◽  
pp. S515
Author(s):  
E. Olsson ◽  
M. Silverborn ◽  
U. Smedh ◽  
G.C. Riise ◽  
J.M. Magnusson ◽  
...  

Thorax ◽  
2018 ◽  
Vol 74 (4) ◽  
pp. 413-416 ◽  
Author(s):  
Peter S Cunningham ◽  
Robert Maidstone ◽  
Hannah J Durrington ◽  
Rajamayier V Venkateswaran ◽  
Marcelo Cypel ◽  
...  

The importance of circadian factors in managing patients is poorly understood. We present two retrospective cohort studies showing that lungs reperfused between 4 and 8 AM have a higher incidence (OR 1.12; 95% CI 1.03 to 1.21; p=0.01) of primary graft dysfunction (PGD) in the first 72 hours after transplantation. Cooling of the donor lung, occurring during organ preservation, shifts the donor circadian clock causing desynchrony with the recipient. The clock protein REV-ERBα directly regulates PGD biomarkers explaining this circadian regulation while also allowing them to be manipulated with synthetic REV-ERB ligands.


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