Development of a model based scoring system for diagnosis of canine disseminated intravascular coagulation with independent assessment of sensitivity and specificity

A scoring system for diagnosis of DIC is proposed which encludes anam estic, clinical and laboratory criteria. From anamnestic criteria triwerinp event which lead to microeirculatory disturbances, like peripheral stasis (hysovolaemia, cardia; insufficiency) thrombin-inducers (septicaemia, haemolysis) and vascular damage (haemolytic-uraemic-syndrome, g ant haemangioma) score1 point as well as a positive etnanol gelation test. Clinical parameters include all organs which show sirns of a throrr. ho-haemormafic syndrom. They represent shock-orpans and can be diagnosed clinically by simultaneous appearance of bleeding symptoms and microthromrosis, like oliguria and haematuria (shock-orean kidney) or purpura and “Intravital death sports” (shock-orfran skin) or haemoptoe and hyaline membrane (shock-organ lunps). Laboratory parameters of DIC include the annearanee of helmet cells, of leuko- or neutropenia, of thrombocytopenia and of the demonstration of consumption coagulopathy (low F I, II, V, XIII) and of fibrinolysis (increased FDP, low plasminogen, low Antithrombin III). From our experience a score of 7 points or more is compatible with DIC.

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A multicenter, prospective validation study of the Japanese Association for Acute Medicine disseminated intravascular coagulation scoring system in patients with severe sepsis

Critical Care ◽

10.1186/cc12783 ◽

2013 ◽

Vol 17 (3) ◽

pp. R111 ◽

Cited By ~ 93

Author(s):

Satoshi Gando ◽

Daizoh Saitoh ◽

Hiroshi Ogura ◽

Seitaro Fujishima ◽

Toshihiko Mayumi ◽

...

Keyword(s):

Severe Sepsis ◽

Disseminated Intravascular Coagulation ◽

Validation Study ◽

Scoring System ◽

Acute Medicine ◽

Japanese Association ◽

Intravascular Coagulation

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A multicenter, prospective evaluation of the Chinese Society of Thrombosis and Hemostasis Scoring System for disseminated intravascular coagulation

Thrombosis Research ◽

10.1016/j.thromres.2018.11.022 ◽

2019 ◽

Vol 173 ◽

pp. 131-140 ◽

Cited By ~ 7

Author(s):

Lili Luo ◽

Yingying Wu ◽

Ting Niu ◽

Yue Han ◽

Ying Feng ◽

...

Keyword(s):

Disseminated Intravascular Coagulation ◽

Scoring System ◽

Chinese Society ◽

Prospective Evaluation ◽

Intravascular Coagulation

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Prognostic accuracy of different disseminated intravascular coagulation criteria in critically ill adult patients: a protocol for a systematic review and meta-analysis

BMJ Open ◽

10.1136/bmjopen-2018-024878 ◽

2018 ◽

Vol 8 (12) ◽

pp. e024878

Author(s):

Jumpei Yoshimura ◽

Kazuma Yamakawa ◽

Akira Kodate ◽

Mari Kodate ◽

Satoshi Fujimi

Keyword(s):

Systematic Review ◽

Diagnostic Accuracy ◽

Critically Ill ◽

Disseminated Intravascular Coagulation ◽

Scoring System ◽

Meta Analysis ◽

Adult Patients ◽

Intravascular Coagulation ◽

Operating Points ◽

Receiver Operating

IntroductionDisseminated intravascular coagulation (DIC) is a common and serious condition that can lead to poor outcomes in critically ill patients. To make a correct diagnosis and improve the outcome of patients with DIC, several organisations have put forward DIC scoring systems. However, which criteria is the best to use for diagnosing DIC remains a continuing controversy even though many studies have been conducted to validate the diagnostic accuracy of each DIC scoring system.Methods and analysisWe will conduct a systematic review and meta-analysis of the diagnostic accuracy of DIC criteria for the prediction of mortality in critically ill adult patients. The primary objective is to assess the predictive values of the DIC criteria of Japanese Association for Acute Medicine, International Society on Thrombosis and Haemostasis, Japanese Ministry of Health and Welfare, Korean Society on Thrombosis and Hemostasis and Chinese Diagnostic Scoring System for 28-day mortality. We will search electronic bibliographic databases such as MEDLINE, EMBASE and Cochrane Central Register of Controlled Trials. Two reviewers will independently screen titles and abstracts, perform full article reviews and extract study data. We will report study characteristics and assess methodological quality using the Quality of Diagnostic Accuracy Studies-II tool. If pooling is appropriate, we will compute parameter estimates using bivariate random-effects and hierarchical summary receiver operating characteristic models to produce summary receiver operating curves, summary operating points (pooled sensitivity and specificity) and 95% confidence regions around the summary operating points. Clinical and methodological subgroup and sensitivity analyses will be performed to explore heterogeneity.Ethics and disseminationThis systematic review will help physicians diagnose DIC accurately and improve their clinical practice in critically ill settings. Approval from an ethics committee is not required. The findings will be disseminated through publication in a peer-reviewed journal.PROSPERO registration numberCRD42017079350.

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