Definitive surgical therapy for refractory radiation cystitis: Evaluating effectiveness, tolerability, and extent of surgical approach

Background. Macroprolactinemia is defined as predominance of high molecular weight prolactin forms in the circulation. Although macroprolactin is considered as a biologically inactive molecule, some authorities suggest treatment in symptomatic cases. Gigantomastia is defined as excess breast tissue and most cases in the literature were treated by surgical intervention.Case. A 44-year-old woman was admitted to our clinic with gigantomastia and galactorrhea. The patient had a demand for surgical therapy. In laboratory examination, she had hyperprolactinemia and macroprolactinemia. Pituitary imaging revealed 6 mm microadenoma in right side of the hypophysis. Since she was symptomatic, cabergolin treatment was started. Macroprolactin became negative, breast circumference decreased significantly, and galactorrhea resolved after treatment.Conclusion. Gigantomastia might be the presenting symptom in patients with macroprolactinemia. In these patients medical treatment with cabergoline may be used initially as an alternative to surgical approach.

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Surgical therapy in infertile men with ejaculatory duct obstruction: technique and outcome of a standardized surgical approach

Human Reproduction ◽

10.1093/humrep/15.6.1364 ◽

2000 ◽

Vol 15 (6) ◽

pp. 1364-1368 ◽

Cited By ~ 43

Author(s):

Immo Schroeder-Printzen ◽

Martin Ludwig ◽

Frank Köhn ◽

Wolfgang Weidner

Keyword(s):

Surgical Therapy ◽

Surgical Approach ◽

Ejaculatory Duct ◽

Duct Obstruction ◽

Infertile Men ◽

Ejaculatory Duct Obstruction

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Surgical therapy of esophageal carcinoma: the influence of surgical approach and esophageal resection on cardiopulmonary function

European Journal of Cardio-Thoracic Surgery ◽

10.1016/s1010-7940(96)01106-2 ◽

1997 ◽

Vol 11 (1) ◽

pp. 32-37 ◽

Cited By ~ 70

Author(s):

C.A Jacobi ◽

H.U Zieren ◽

J.M Müller ◽

H Pichlmaier

Keyword(s):

Esophageal Carcinoma ◽

Surgical Therapy ◽

Surgical Approach ◽

Esophageal Resection ◽

Cardiopulmonary Function

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Surgical Approach: The Indication and Efficacy of Surgical Therapy for Aspiration Pneumonia

Respiratory Disease Series: Diagnostic Tools and Disease Managements - Aspiration Pneumonia ◽

10.1007/978-981-15-4506-1_20 ◽

2020 ◽

pp. 205-216

Author(s):

Masamitsu Hyodo ◽

Asuka Nagao ◽

Kahori Hirose

Keyword(s):

Aspiration Pneumonia ◽

Surgical Therapy ◽

Surgical Approach

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MINIMALLY-INVASIVE NON-SURGICAL VS. SURGICAL APPROACH FOR PERIODONTAL INTRABONY DEFECTS: A RANDOMISED CONTROLLED TRIAL

10.21203/rs.2.263/v1 ◽

2019 ◽

Author(s):

Luigi Nibali ◽

Vasiliki Koidou ◽

Simona Salomone ◽

Thomas Hamborg ◽

R Allaker ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Minimally Invasive ◽

Surgical Therapy ◽

Surgical Approach ◽

Controlled Trial ◽

Intrabony Defects ◽

Defect Depth ◽

Intrabony Defect ◽

Patient Reported ◽

Randomised Controlled

Abstract Background: Periodontal intrabony defects are usually treated surgically with the aim to increase attachment and bone levels and reduce risk of progression. However, recent studies have suggested that a minimally-invasive non-surgical therapy (MINST) leads to considerable clinical and radiographic defect depth reductions in intrabony defects. The aim of this study is to compare the efficacy of a modified MINST approach with a surgical approach (modified minimally-invasive surgical therapy, M-MIST) for the treatment of intrabony defects. Methods: This is a parallel-group single-centre examiner-blind non-inferiority randomised controlled trial with a sample size of 66 patients. Inclusion criteria are age 25-70, diagnosis of periodontitis stage III or IV (grades A to C), presence of ≥1 ‘intrabony defect’ with probing pocket depth (PPD) >5 mm and intrabony defect depth ≥3mm. Smokers and patients who received previous periodontal treatment to the study site within the last 12 months will be excluded. Patients will be randomly assigned to either the modified MINST or the M-MIST protocol and will be assessed up to 15 months following initial therapy. The primary outcome of the study is radiographic intrabony defect depth change at 15 months follow-up. Secondary outcomes are PPD and clinical attachment loss (CAL) change, inflammatory markers and growth factors in gingival crevicular fluid, bacterial detection, gingival inflammation and healing (as measured by geometric/thermal camera imaging in a subset of 10 test and 10 control patients) and patient-reported outcomes. Discussion: This study will produce evidence about the clinical efficacy and potential applicability of a modified MINST protocol for the treatment of periodontal intrabony defects, as a less invasive alternative to the use of surgical procedures. Trial registration: This study was registered on clinicaltrials.gov NCT03797807 (date registered: 9 January 2019). Keywords: Periodontitis, intrabony defect, minimally-invasive, quality of life, bone

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Minimally-invasive Non-surgical Vs. Surgical Approach for Periodontal Intrabony Defects: a Randomised Controlled Trial

10.21203/rs.2.263/v2 ◽

2019 ◽

Author(s):

Luigi Nibali ◽

Vasiliki Koidou ◽

Simona Salomone ◽

Thomas Hamborg ◽

R Allaker ◽

...

Keyword(s):

Randomised Controlled Trial ◽

Minimally Invasive ◽

Surgical Therapy ◽

Surgical Approach ◽

Controlled Trial ◽

Intrabony Defects ◽

Defect Depth ◽

Intrabony Defect ◽

Patient Reported ◽

Randomised Controlled

Abstract Background Periodontal intrabony defects are usually treated surgically with the aim to increase attachment and bone levels and reduce risk of progression. However, recent studies have suggested that a minimally-invasive non-surgical therapy (MINST) leads to considerable clinical and radiographic defect depth reductions in intrabony defects. The aim of this study is to compare the efficacy of a modified MINST approach with a surgical approach (modified minimally-invasive surgical therapy, M-MIST) for the treatment of intrabony defects. Methods This is a parallel-group single-centre examiner-blind non-inferiority randomised controlled trial with a sample size of 66 patients. Inclusion criteria are age 25-70, diagnosis of periodontitis stage III or IV (grades A to C), presence of ≥1 ‘intrabony defect’ with probing pocket depth (PPD) >5 mm and intrabony defect depth ≥3mm. Smokers and patients who received previous periodontal treatment to the study site within the last 12 months will be excluded. Patients will be randomly assigned to either the modified MINST or the M-MIST protocol and will be assessed up to 15 months following initial therapy. The primary outcome of the study is radiographic intrabony defect depth change at 15 months follow-up. Secondary outcomes are PPD and clinical attachment loss (CAL) change, inflammatory markers and growth factors in gingival crevicular fluid, bacterial detection, gingival inflammation and healing (as measured by geometric/thermal camera imaging in a subset of 10 test and 10 control patients) and patient-reported outcomes. Discussion This study will produce evidence about the clinical efficacy and potential applicability of a modified MINST protocol for the treatment of periodontal intrabony defects, as a less invasive alternative to the use of surgical procedures.

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