Effectiveness of a single dose of Japanese encephalitis vaccine among adults, Assam, India, 2012–2018

Vaccine ◽  
2021 ◽  
Author(s):  
Siraj A. Khan ◽  
Parveena Choudhury ◽  
Sanjeeb Kakati ◽  
Rimamoni Doley ◽  
Manash P. Barman ◽  
...  
Keyword(s):  
Single Dose ◽  
Japanese Encephalitis ◽  
Japanese Encephalitis Vaccine

scholarly journals An Advax-adjuvanted Inactivated Cell-culture Japanese Encephalitis Vaccine Induces Broadly Neutralising Anti-flavivirus Antibodies and T-cell Immunity and Provides Single Dose Protection

2021 ◽  
Author(s):  
Tomoyoshi Komiya ◽  
Yoshikazu Honda-Okubo ◽  
Jeremy Baldwin ◽  
Nikolai Petrovsky
Keyword(s):  
Cell Culture ◽  
Single Dose ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Neutralising Antibodies ◽  
Th17 Response ◽  
Japanese Encephalitis Vaccine ◽  
Cell Immunity ◽  
Equine Studies ◽  
The Military

ccJE+Advax is an inactivated cell culture Japanese encephalitis (JE) vaccine formulated with Advax™, a novel polysaccharide adjuvant based on delta inulin. This vaccine has previously shown promise in murine and equine studies and the current study sought to better understand its mechanism of action and assess the feasibility of single dose vaccine protection. Mice immunised with ccJE-Advax had higher serum neutralisation titres than those immunised with ccJE alone or with alum adjuvant. ccJE+Advax induced extraordinarily broad cross-neutralising antibodies against multiple flaviviruses including West Nile virus (WNV), Murray Valley Encephalitis Virus (MVEV), St Louis Encephalitis virus (SLE) and Dengue-1 and -2 viruses. Notably, the DENV-2 cross-neutralising antibodies from ccJE+Advax immunised mice uniquely had no DENV-2 antibody dependent enhancement (ADE) activity, by contrast to high ADE activity seen with DENV-1 cross-reactive antibodies induced by mbJE or ccJE alone or with alum adjuvant. JEV-stimulated splenocytes from ccJE+Advax immunised mice showed increased IL-17 and IFN-γ production, consistent with a mixed Th1 and Th17 response, whereas ccJE-alum was associated with production of mainly Th2 cytokines. There is an ongoing lack of human vaccines against particular flaviviruses, including WNV, SLE and MVEV. Given its ability to provide single-dose JEV protection as well as to induce broadly neutralising antibodies free of ADE activity, ccJE+Advax vaccine could be highly useful in all situations where rapid protection is desirable but ADE needs to be avoided, e.g. during a local outbreak or for use in travellers or the military requiring rapid travel to JEV endemic regions.

scholarly journals Persistence of Immune Responses With an Inactivated Japanese Encephalitis Single-Dose Vaccine, JENVAC and Interchangeability With a Live-Attenuated Vaccine

2019 ◽  
Vol 222 (9) ◽  
pp. 1478-1487 ◽  
Author(s):  
Krishna Mohan Vadrevu ◽  
Venugopal Potula ◽  
Vasant Khalatkar ◽  
Niranjana S Mahantshetty ◽  
Atish Shah ◽  
...  
Keyword(s):  
Single Dose ◽  
Japanese Encephalitis ◽  
Healthy Children ◽  
Open Label ◽  
Live Attenuated Vaccine ◽  
Time Points ◽  
Japanese Encephalitis Vaccine ◽  
Randomized Control ◽  
To Receive ◽  
Dose Vaccine

Abstract Background This study reports immunogenicity, safety, and interchangeability of a single-dose, inactivated, Vero-cell derived, JENVAC to the live-attenuated SA 14-14-2 vaccine in healthy children. Methods This phase 4, multicenter, open-label, randomized, control trial enrolled 360 children who were equally randomized to receive a single dose of either JENVAC or SA 14-14-2. Children were followed at various time points, until 2 years (day 720) postvaccination, upon which a subset from each group was divided and allocated to a receive a booster dose or the other vaccine. Results At all time points, immunological measures were statistically higher in the JENVAC group. In the interchangeability study, children receiving 2 doses of JENVAC reported significantly higher response compared with 2 doses of SA 14-14-2. No difference in adverse events was observed. These corroborate with excellent seroprotection after the first dose of an earlier JENVAC study. Conclusions A single-dose vaccination with JENVAC induces protective titers that persist up to 1 year. We report appreciable interchangeability between both vaccines, with JENVAC/JENVAC combination exhibiting the highest immune response. JENVAC is now licensed as a single-dose Japanese encephalitis vaccine.

Immunogenicity of single-dose Vero cell-derived Japanese encephalitis vaccine in Japanese adults

2014 ◽  
Vol 20 (4) ◽  
pp. 238-242 ◽  
Author(s):  
Nozomi Takeshita ◽  
Chang-Kweng Lim ◽  
Yasutaka Mizuno ◽  
Takuro Shimbo ◽  
Akira Kotaki ◽  
...  
Keyword(s):  
Single Dose ◽  
Vero Cell ◽  
Japanese Encephalitis ◽  
Japanese Encephalitis Vaccine ◽  
Japanese Adults

scholarly journals Immunogenicity & safety of a single dose of live-attenuated Japanese encephalitis vaccine SA 14-14-2 in adults

2016 ◽  
Vol 144 (6) ◽  
pp. 886 ◽  
Author(s):  
SirajAhmed Khan ◽  
Sanjeeb Kakati ◽  
Prafulla Dutta ◽  
Purvita Chowdhury ◽  
Jani Borah ◽  
...  
Keyword(s):  
Single Dose ◽  
Japanese Encephalitis ◽  
Japanese Encephalitis Vaccine

Single dose of inactivated Japanese encephalitis vaccine with poly(γ-glutamic acid) nanoparticles provides effective protection from Japanese encephalitis virus

Vaccine ◽  
2008 ◽  
Vol 26 (5) ◽  
pp. 589-594 ◽  
Author(s):  
Shigefumi Okamoto ◽  
Hironori Yoshii ◽  
Toyokazu Ishikawa ◽  
Takami Akagi ◽  
Mitsuru Akashi ◽  
...  
Keyword(s):  
Single Dose ◽  
Glutamic Acid ◽  
Japanese Encephalitis Virus ◽  
Japanese Encephalitis ◽  
Encephalitis Virus ◽  
Effective Protection ◽  
Japanese Encephalitis Vaccine

scholarly journals Single-dose, live-attenuated Japanese encephalitis vaccine in children aged 12–18 months: Randomized, controlled phase 3 immunogenicity and safety trial

2012 ◽  
Vol 8 (7) ◽  
pp. 929-937 ◽  
Author(s):  
Emmanuel Feroldi ◽  
Chitsanu Pancharoen ◽  
Pope Kosalaraksa ◽  
Veerachai Watanaveeradej ◽  
Kerdpanich Phirangkul ◽  
...  
Keyword(s):  
Single Dose ◽  
Japanese Encephalitis ◽  
Phase 3 ◽  
Randomized Controlled ◽  
Japanese Encephalitis Vaccine

Low coverage and acceptable effectiveness of single dose of Japanese encephalitis vaccine, Gorakhpur division, Uttar Pradesh, India, 2013

2014 ◽  
Vol 69 (5) ◽  
pp. 517-520 ◽  
Author(s):  
Manoj V. Murhekar ◽  
Prashant Ranjan ◽  
Sriram Selvaraju ◽  
Ashok Pandey ◽  
Milind M. Gore ◽  
...  
Keyword(s):  
Single Dose ◽  
Japanese Encephalitis ◽  
Uttar Pradesh ◽  
Japanese Encephalitis Vaccine ◽  
Low Coverage
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