Drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

2018 ◽  
Vol 93 ◽  
pp. 170
Author(s):  
Daiju Yamazaki ◽  
Takashi Kitaguchi ◽  
Masakazu Ishimura ◽  
Tomohiko Taniguchi ◽  
Atsuhiro Yamanishi ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Drug Induced ◽  
Ips Cell

scholarly journals A new paradigm for drug-induced torsadogenic risk assessment using human iPS cell-derived cardiomyocytes

2017 ◽  
Vol 84 ◽  
pp. 111-127 ◽  
Author(s):  
Hiroyuki Ando ◽  
Takashi Yoshinaga ◽  
Wataru Yamamoto ◽  
Keiichi Asakura ◽  
Takaaki Uda ◽  
...  
Keyword(s):  
Risk Assessment ◽  
New Paradigm ◽  
Drug Induced ◽  
Ips Cell

New Perspectives on Drug-Induced Liver Injury Risk Assessment of Acyl Glucuronides

2020 ◽  
Vol 33 (7) ◽  
pp. 1551-1560 ◽  
Author(s):  
Markus Walles ◽  
Alan P. Brown ◽  
Alfred Zimmerlin ◽  
Peter End
Keyword(s):  
Risk Assessment ◽  
Liver Injury ◽  
Injury Risk ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Acyl Glucuronides

scholarly journals Biomarkers and Mechanisms of Drug-Induced Vascular Injury in Non-Rodents

2006 ◽  
Vol 34 (1) ◽  
pp. 19-26 ◽  
Author(s):  
Calvert Louden ◽  
David Brott ◽  
Anne Katein ◽  
Thomas Kelly ◽  
Sarah Gould ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Vascular Injury ◽  
Diagnostic Markers ◽  
Target Cells ◽  
Drug Selection ◽  
Primary Target ◽  
Drug Induced ◽  
Candidate Drug ◽  
Safety Studies ◽  
Preclinical Safety

In preclinical safety studies, drug-induced vascular injury can negatively impact candidate-drug selection because there are no obvious diagnostic markers for monitoring this pathology preclinically or clinically. Furthermore, our current understanding of the pathogenesis of this lesion is limited. While vasodilatation and increased shear stress appear to play a role, the exact mechanism(s) of injury to the primary target cells, smooth muscle (SMC) and endothelial cell (EC), are unknown. Evaluation of potential novel markers for clinical monitoring with a mechanistic underpinning would add value in risk assessment and risk management. This mini review focuses on the efforts and progress to identify diagnostic markers as well as understanding the mechanism of action in nonrodent drug-induced vascular injury.

scholarly journals Drug-induced liver injury: recent advances in diagnosis and risk assessment

Gut ◽  
2017 ◽  
Vol 66 (6) ◽  
pp. 1154-1164 ◽  
Author(s):  
Gerd A Kullak-Ublick ◽  
Raul J Andrade ◽  
Michael Merz ◽  
Peter End ◽  
Andreas Benesic ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Liver Injury ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Recent Advances

scholarly journals Assessment of Testing Methods for Drug-Induced Repolarization Delay and Arrhythmias in an iPS Cell–Derived Cardiomyocyte Sheet: Multi-site Validation Study

2014 ◽  
Vol 124 (4) ◽  
pp. 494-501 ◽  
Author(s):  
Yuji Nakamura ◽  
Junko Matsuo ◽  
Norimasa Miyamoto ◽  
Atsuko Ojima ◽  
Kentaro Ando ◽  
...  
Keyword(s):  
Validation Study ◽  
Testing Methods ◽  
Drug Induced ◽  
Ips Cell

Metabolic activation and drug-induced liver injury:in vitroapproaches for the safety risk assessment of new drugs

2015 ◽  
Vol 36 (6) ◽  
pp. 752-768 ◽  
Author(s):  
M. José Gómez-Lechón ◽  
Laia Tolosa ◽  
M. Teresa Donato
Keyword(s):  
Risk Assessment ◽  
Metabolic Activation ◽  
New Drugs ◽  
Drug Induced ◽  
Safety Risk
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