Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

2020 ◽  
Vol 105 ◽  
pp. 106884 ◽  
Author(s):  
Nina Brinkwirth ◽  
Kiyoshi Takasuna ◽  
Masafumi Doi ◽  
Nadine Becker ◽  
Alison Obergrussberger ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Best Practices ◽  
Patch Clamp ◽  
Calibration Standards ◽  
Reliable Identification ◽  
Automated Patch Clamp

scholarly journals Reliable Identification of hERG Liability in Drug Discovery by Automated Patch Clamp

2020 ◽  
Vol 118 (3) ◽  
pp. 116a-117a
Author(s):  
Michael George ◽  
Rodolfo Haedo ◽  
Nina Brinkwirth ◽  
Nadine Becker ◽  
Claudia S. Haarmann ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Reliable Identification ◽  
Automated Patch Clamp

Reliable identification of hERG liability in drug discovery by automated patch clamp

2020 ◽  
Vol 105 ◽  
pp. 106743
Author(s):  
Sonja Stoelzle-Feix ◽  
Nina Brinkwirth ◽  
Nadine Becker ◽  
Claudia Haarmann ◽  
Ronald Knox ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Reliable Identification ◽  
Automated Patch Clamp

scholarly journals Unattended Drug Discovery Screening Workflow in a 384-Well Automated Patch Clamp System

2021 ◽  
Vol 120 (3) ◽  
pp. 248a
Author(s):  
Nina Brinkwirth ◽  
Alison Obergrussberger ◽  
Nadine Becker ◽  
Tim Strassmaier ◽  
James L. Costantin ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Automated Patch Clamp

Exciting new impedance and automated patch clamp for safety screening and drug discovery

2014 ◽  
Vol 70 (3) ◽  
pp. 316-317
Author(s):  
David Guinot ◽  
Tobias Schwarzenberger ◽  
Sonja Stoelzle ◽  
Ulrich Thomas ◽  
Michael George ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Automated Patch Clamp

scholarly journals Automated patch clamp in drug discovery: major breakthroughs and innovation in the last decade

2020 ◽  
Vol 16 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Alison Obergrussberger ◽  
Søren Friis ◽  
Andrea Brüggemann ◽  
Niels Fertig
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Automated Patch Clamp

scholarly journals Development and Validation of ASIC1a Ligand-Gated Ion Channel Drug Discovery Assays on Automated Patch Clamp Platforms

2021 ◽  
Vol 120 (3) ◽  
pp. 338a
Author(s):  
Marc Rogers ◽  
Sam Manyweathers ◽  
Tom Götze ◽  
Nadine Becker ◽  
Ilka Rinke ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Patch Clamp ◽  
Ion Channel ◽  
Automated Patch Clamp ◽  
Development And Validation
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