Continuous monitoring of bovine spongiform encephalopathy rapid test performance by weak positive tissue controls and quality control charts

The preferred method to determine the prevalence of bovine spongiform encephalopathy (BSE) in a country is to use immunology-based rapid-tests. Though these tests are validated to detect C-type BSE disease–associated prion (PrPsc), test-specific properties may influence their ability to detect H- and/or L-type BSE PrPsc, where both are atypical from C-type PrPsc. Molecular characterization shows atypical BSE PrPsc to have a different sensitivity to proteinase activity and different affinities for certain prion-specific antibodies. It is important to understand how atypical BSE PrPsc may affect the performance of rapid-tests, which are typically dependant on the use of specific proteases and antibodies. The current study used experimentally generated C-, H-, and L-type BSE PrPsc to evaluate 3 tests used in various national BSE surveillance programs: an immunochromatographic assay, a standard sandwich enzyme-linked immunosorbent assay (stndELISA), and a PrPsc-conformation–specific ELISA (confELISA). Although BSE PrPsc type had some effects on rapid-test performance, analytical sensitivity for atypical BSE PrPsc on all 3 platforms was not significantly compromised. When testing for atypical BSE PrPsc, the 3 tests were able to meet the same requirements that the European Food Safety Authority set when evaluating the tests for C-type BSE PrPsc.

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The Inertial Properties of Quality Control Charts

Technometrics ◽

10.1198/004017005000000256 ◽

2005 ◽

Vol 47 (4) ◽

pp. 425-436 ◽

Cited By ~ 97

Author(s):

William H Woodall ◽

Mahmoud A Mahmoud

Keyword(s):

Quality Control ◽

Control Charts ◽

Quality Control Charts

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Improvement of the safety of the red pepper spice with FMEA and post processing EWMA quality control charts

Journal of Food Science and Technology ◽

10.1007/s13197-011-0371-7 ◽

2011 ◽

Vol 50 (3) ◽

pp. 466-476 ◽

Cited By ~ 6

Author(s):

Sibel Ozilgen ◽

Seyda Bucak ◽

Mustafa Ozilgen

Keyword(s):

Quality Control ◽

Control Charts ◽

Red Pepper ◽

Post Processing ◽

Quality Control Charts

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Indian Food Specialties Limited

Vikalpa The Journal for Decision Makers ◽

10.1177/0256090920020107 ◽

2002 ◽

Vol 27 (1) ◽

pp. 55-68

Author(s):

Satish Y Deodhar ◽

Devanath Tirupati

Keyword(s):

Quality Control ◽

Control Charts ◽

Hazard Analysis ◽

Process Capability ◽

Process Capability Indices ◽

Market Conditions ◽

Quality Control Charts ◽

Critical Control Points ◽

Capability Indices ◽

Indian Food

Indian Food Specialties Limited (IFS) introduced tools of food quality management in May 2000 in response to changing market conditions and poor profitability. Spoilage in the production process was very high and the company had incurred losses for three successive years starting from 1996-97. The company addressed quality concerns by introducing management tools such as quality control charts and process capability indices, and was considering implementation of a food safety system called Hazard Analysis and Critical Control Points (HACCP). The case describes the changing market conditions and the company's response to improving quality, and provides a learning exercise on quality control charts, process capability indices, and HACCP.

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