Identification of a conserved linear epitope on the VP1 protein of serotype O foot-and-mouth disease virus by neutralising monoclonal antibody 8E8

2011 ◽  
Vol 155 (1) ◽  
pp. 291-299 ◽  
Author(s):  
Decheng Yang ◽  
Chunyuan Zhang ◽  
Lei Zhao ◽  
Guohui Zhou ◽  
Haiwei Wang ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Linear Epitope ◽  
Vp1 Protein ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Application of VP1 protein to develop monoclonal antibody against foot-and-mouth disease virus Asia1 type

2009 ◽  
Vol 24 (3) ◽  
pp. 215-220 ◽  
Author(s):  
Tong Lin ◽  
Jun-zheng Du ◽  
Jun-jun Shao ◽  
Guo-zheng Cong ◽  
Shuai Song ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vp1 Protein ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Field outbreak strains of serotype O foot-and-mouth disease virus from India with a deletion in the immunodominant βG-βH loop of the VP1 protein

2012 ◽  
Vol 157 (10) ◽  
pp. 1967-1970 ◽  
Author(s):  
Biswajit Das ◽  
Aniket Sanyal ◽  
Saravanan Subramaniam ◽  
Jajati K. Mohapatra ◽  
Bramhadev Pattnaik
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vp1 Protein ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Antiviral potential of ivermectin against foot-and-mouth disease virus, serotype O, A and Asia-1

2021 ◽  
pp. 104914
Author(s):  
Zahra Naeem ◽  
Sohail Raza ◽  
Saba Afzal ◽  
Ali Ahmad Sheikh ◽  
Muhammad Muddassir Ali ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth

scholarly journals Expression and Immunogenicity of Two Recombinant Fusion Proteins Comprising Foot-and-Mouth Disease Virus Structural Protein VP1 and DC-SIGN-Binding Glycoproteins

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Xinsheng Liu ◽  
Jianliang Lv ◽  
Yuzhen Fang ◽  
Peng Zhou ◽  
Yanzhen Lu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Disease Virus ◽  
Fusion Proteins ◽  
Insect Cells ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Vp1 Protein ◽  
Sf9 Insect Cells ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Improving vaccine immunogenicity by targeting antigens to dendritic cells has recently emerged as a new design strategy in vaccine development. In this study, the VP1 gene of foot-and-mouth disease virus (FMDV) serotype A was fused with the gene encoding human immunodeficiency virus (HIV) membrane glycoprotein gp120 or C2-V3 domain of hepatitis C virus (HCV) envelope glycoprotein E2, both of which are DC-SIGN-binding glycoproteins. After codon optimization, the VP1 protein and the two recombinant VP1-gp120 and VP1-E2 fusion proteins were expressed in Sf9 insect cells using the insect cell-baculovirus expression system. Western blotting showed that the VP1 protein and two recombinant VP1-gp120 and VP1-E2 fusion proteins were correctly expressed in the Sf9 insect cells and had good reactogenicity. Guinea pigs were then immunized with the purified proteins, and the resulting humoral and cellular immune responses were analyzed. The VP1-gp120 and VP1-E2 fusion proteins induced significantly higher specific anti-FMDV antibody levels than the VP1 protein and stronger cell-mediated immune responses. This study provides a new perspective for the development of novel FMDV subunit vaccines.

A vaccine-matching assessment of different genetic variants of serotype O foot-and-mouth disease virus isolated in Ethiopia between 2011 and 2014

2020 ◽  
Vol 165 (8) ◽  
pp. 1749-1757
Author(s):  
Yeneneh Tesfaye ◽  
Fazlurrahman Khan ◽  
Martha Yami ◽  
Jemma Wadsworth ◽  
Nick J. Knowles ◽  
...  
Keyword(s):  
Disease Virus ◽  
Genetic Variants ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Serotype O ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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