What are the limits of the packaging capacity for genomic RNA in the cores of rotaviruses and of other members of the Reoviridae?

2020 ◽  
Vol 276 ◽  
pp. 197822 ◽  
Author(s):  
Ulrich Desselberger
1976 ◽  
Vol 19 (2) ◽  
pp. 743-745 ◽  
Author(s):  
M V Marshall ◽  
R B Arlinghaus

1998 ◽  
Vol 56 (1) ◽  
pp. 69-76 ◽  
Author(s):  
Xiaohong Shi ◽  
Mifang Liang ◽  
Changshou Hang ◽  
Gan Song ◽  
Conall McCaughey ◽  
...  

1990 ◽  
Vol 172 (2) ◽  
pp. 1129-1132
Author(s):  
J Anné ◽  
L Van Mellaert ◽  
H Eyssen
Keyword(s):  

2008 ◽  
Vol 82 (9) ◽  
pp. 4461-4470 ◽  
Author(s):  
Ranjit Warrier ◽  
Benjamin R. Linger ◽  
Barbara L. Golden ◽  
Richard J. Kuhn

ABSTRACT Sindbis virus is an enveloped positive-sense RNA virus in the alphavirus genus. The nucleocapsid core contains the genomic RNA surrounded by 240 copies of a single capsid protein. The capsid protein is multifunctional, and its roles include acting as a protease, controlling the specificity of RNA that is encapsidated into nucleocapsid cores, and interacting with viral glycoproteins to promote the budding of mature virus and the release of the genomic RNA into the newly infected cell. The region comprising amino acids 81 to 113 was previously implicated in two processes, the encapsidation of the viral genomic RNA and the stable accumulation of nucleocapsid cores in the cytoplasm of infected cells. In the present study, specific amino acids within this region responsible for the encapsidation of the genomic RNA have been identified. The region that is responsible for nucleocapsid core accumulation has considerable overlap with the region that controls encapsidation specificity.


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