Stability of antibody drug conjugate formulations evaluated using solid-state hydrogen-deuterium exchange mass spectrometry

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Hydrogen Deuterium ◽

Antibody Drug

Optimizing the Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry (ssHDX-MS)

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b00614 ◽

2019 ◽

Vol 16 (11) ◽

pp. 4485-4495 ◽

Cited By ~ 2

Author(s):

Lokesh Kumar ◽

Karthik Balakrishna Chandrababu ◽

Shenbaga Moorthy Balakrishnan ◽

Andrea Allmendinger ◽

Benjamin Walters ◽

...

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Antigen Binding ◽

Hydrogen Deuterium ◽

Fragment Antigen Binding

Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-018-1966-2 ◽

2018 ◽

Vol 29 (7) ◽

pp. 1524-1531 ◽

Cited By ~ 7

Author(s):

Richard Y.-C. Huang ◽

Steven R. O’Neil ◽

Daša Lipovšek ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Drug Conjugate ◽

Hydrogen Deuterium ◽

Effects of drying method and excipient on structure and stability of protein solids using solid-state hydrogen/deuterium exchange mass spectrometry (ssHDX-MS)

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2019.118470 ◽

2019 ◽

Vol 567 ◽

pp. 118470 ◽

Cited By ~ 3

Author(s):

Nathan E. Wilson ◽

Elizabeth M. Topp ◽

Qi Tony Zhou

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Drying Method ◽

Structure And Stability ◽

Hydrogen Deuterium ◽

Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry (ssHDX-MS) of Lyophilized Poly-d,l-Alanine

Molecular Pharmaceutics ◽

10.1021/acs.molpharmaceut.9b00162 ◽

2019 ◽

Vol 16 (7) ◽

pp. 2935-2946 ◽

Cited By ~ 6

Author(s):

Rajashekar Kammari ◽

Elizabeth M. Topp

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Effects of temperature and relative humidity in D2O on solid-state hydrogen deuterium exchange mass spectrometry (ssHDX-MS)

International Journal of Pharmaceutics ◽

10.1016/j.ijpharm.2021.120263 ◽

2021 ◽

Vol 596 ◽

pp. 120263

Author(s):

Rishabh Tukra ◽

Sam Gardner ◽

Elizabeth M. Topp

Keyword(s):

Mass Spectrometry ◽

Solid State ◽

Relative Humidity ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Effects Of Temperature

Conformation and Dynamics of Interchain Cysteine-Linked Antibody-Drug Conjugates as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/ac404003q ◽

2014 ◽

Vol 86 (5) ◽

pp. 2657-2664 ◽

Cited By ~ 66

Author(s):

Lucy Yan Pan ◽

Oscar Salas-Solano ◽

John F. Valliere-Douglass

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Antibody Drug Conjugates ◽

Drug Conjugates ◽

Hydrogen Deuterium ◽

Antibody Drug

Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-017-1831-8 ◽

2017 ◽

Vol 29 (1) ◽

pp. 85-94 ◽

Cited By ~ 4

Author(s):

Thamina Acter ◽

Seulgidaun Lee ◽

Eunji Cho ◽

Maeng-Joon Jung ◽

Sunghwan Kim

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Atmospheric Pressure Photoionization ◽

Hydrogen Deuterium ◽

Continuous Feeding

Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry

Journal of Structural Biology ◽

10.1016/j.jsb.2015.04.006 ◽

2015 ◽

Vol 190 (2) ◽

pp. 250-259 ◽

Cited By ~ 11

Author(s):

Dong Kyun Kim ◽

Youngjoo Yun ◽

Hee Ryung Kim ◽

Min-Duk Seo ◽

Ka Young Chung

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

Analytica Chimica Acta ◽

10.1016/j.aca.2016.08.006 ◽

2016 ◽

Vol 940 ◽

pp. 8-20 ◽

Cited By ~ 36

Author(s):

Bin Deng ◽

Cristina Lento ◽

Derek J. Wilson

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium ◽