Aldosterone Production in Human Adrenocortical Cells Is Stimulated by High-Density Lipoprotein 2 (HDL2) through Increased Expression of Aldosterone Synthase (CYP11B2)

2011 ◽  
Vol 2011 ◽  
pp. 46-47
Author(s):  
P.P. Toth
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Adrenocortical Cells ◽  
Aldosterone Synthase ◽  
Aldosterone Production

scholarly journals Aldosterone Production in Human Adrenocortical Cells Is Stimulated by High-Density Lipoprotein 2 (HDL2) through Increased Expression of Aldosterone Synthase (CYP11B2)

Endocrinology ◽  
2011 ◽  
Vol 152 (3) ◽  
pp. 751-763 ◽  
Author(s):  
Yewei Xing ◽  
Anthony Cohen ◽  
George Rothblat ◽  
Sandhya Sankaranarayanan ◽  
Ginny Weibel ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
Kinase Inhibitor ◽  
Cell Model ◽  
Density Lipoprotein ◽  
Fold Increase ◽  
High Density ◽  
Dependent Manner ◽  
Active Components ◽  
Calmodulin Kinase ◽  
Aldosterone Production

Adrenal aldosterone production is regulated by physiological agonists at the level of early and late rate-limiting steps. Numerous studies have focused on the role of lipoproteins including high-density lipoprotein (HDL) as cholesterol providers in this process; however, recent research suggests that HDL can also act as a signaling molecule. Herein, we used the human H295R adrenocortical cell model to study the effects of HDL on adrenal aldosterone production and CYP11B2 expression. HDL, especially HDL2, stimulated aldosterone synthesis by increasing expression of CYP11B2. HDL treatment increased CYP11B2 mRNA in both a concentration- and time-dependent manner, with a maximal 19-fold increase (24 h, 250 μg/ml of HDL). Effects of HDL on CYP11B2 were not additive with natural agonists including angiotensin II or K+. HDL effects were likely mediated by a calcium signaling cascade, because a calcium channel blocker and a calmodulin kinase inhibitor abolished the CYP11B2-stimulating effects. Of the two subfractions of HDL, HDL2 was more potent than HDL3 in stimulating aldosterone and CYP11B2. Further studies are needed to identify the active components of HDL, which regulate aldosterone production.

High-density lipoprotein is a potential growth factor for adrenocortical cells

2006 ◽  
Vol 344 (1) ◽  
pp. 226-232 ◽  
Author(s):  
Koji Murao ◽  
Hitomi Imachi ◽  
Wenming Cao ◽  
Xiao Yu ◽  
Junhua Li ◽  
...  
Keyword(s):  
Growth Factor ◽  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Adrenocortical Cells ◽  
Potential Growth

Effect of lovastatin on the interaction between high density lipoprotein and cultured rat adrenocortical cells

1991 ◽  
Vol 88 (2-3) ◽  
pp. 235-242 ◽  
Author(s):  
Dmitri Sviridov ◽  
Noel Fidge ◽  
Vadim Repin ◽  
Vladimir Smirnov
Keyword(s):  
High Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Adrenocortical Cells
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