Pre and post intervention study of antiblastic drugs contamination surface levels at a Pharmacy Department Compounding Area using a closed system drug transfer device and a decontamination process

2018 ◽  
Vol 95 ◽  
pp. 1-7 ◽  
Author(s):  
Silvia Valero ◽  
Eduardo López-Briz ◽  
Nieves Vila ◽  
Antonio Solana ◽  
Mar Melero ◽  
...  
Keyword(s):  
Closed System ◽  
Intervention Study ◽  
Post Intervention ◽  
Drug Transfer ◽  
Pharmacy Department ◽  
Transfer Device

scholarly journals Validation of chemotherapy drug vapor containment of an air cleaning closed-system drug transfer device

2021 ◽  
pp. 107815522110306
Author(s):  
Galit Levin ◽  
Paul JM Sessink
Keyword(s):  
Activated Carbon ◽  
Closed System ◽  
Membrane Filter ◽  
Drug Transfer ◽  
Glass Vessel ◽  
Air Cleaning ◽  
No Release ◽  
Activated Carbon Filter ◽  
Carbon Filter ◽  
Transfer Device

Purpose The purpose of this study was to test the efficacy of ChemfortTM, an air filtration closed-system drug transfer device to prevent release of chemotherapy drug vapors and aerosols under extreme conditions. The air cleaning system is based on the adsorption of drug vapors by an activated carbon filter in the Vial Adaptor before the air is released out of the drug vial. The functionality of the carbon filter was also tested at the end of device’s shelf life, and after a contact period with drug vapors for 7 days. Cyclophosphamide and 5-fluorouracil were the chemotherapy drugs tested. Methods The Vial Adaptor was attached to a drug vial and both were placed in a glass vessel. A needle was punctured through the vessel stopper and the Vial Adaptor septum to allow nitrogen gas to flow into the vial and to exit the vial via the air filter into the glass vessel which was connected to a cold trap. Potential contaminated surfaces in the trap system were wiped or rinsed to collect the escaped drug. Samples were analyzed using liquid chromatography tandem mass spectrometry. Results Cyclophosphamide and 5-fluorouracil were detected on most surfaces inside the trap system for all Vial Adaptors without an activated carbon filter. Contamination did not differ between the Vial Adaptors with and without membrane filter indicating no effect of the membrane filter. The results show no release of either drug for the Vial Adaptors with an activated carbon filter even after 3 years of simulated aging and 7 days of exposure to drug vapors. Conclusions Validation of air cleaning CSTDs is important to secure vapor and aerosol containment of chemotherapy and other hazardous drugs. The presented test method has proven to be appropriate for the validation of ChemfortTM Vial Adaptors. No release of cyclophosphamide and 5- fluorouracil was found even for Vial Adaptors after 3 years of simulated aging and 7 days of exposure to drug vapors.

scholarly journals Use of a closed-system drug transfer device reduces contamination with doxorubicin during bolus injection

2020 ◽  
Vol 29 (10) ◽  
pp. S15-S21
Author(s):  
Tom Marler-Hausen ◽  
Chris Holt ◽  
Christine Headley ◽  
Paul Sessink
Keyword(s):  
Closed System ◽  
Environmental Contamination ◽  
Bolus Injection ◽  
Working Environment ◽  
Drug Transfer ◽  
Current Technique ◽  
Transfer Device

Background: Administration of doxorubicin via bolus injection may result in environmental contamination and a risk of nurses becoming exposed. Small spills are frequently observed by nurses when syringes are connected to, and disconnected from, infusion lines. Aims: The effect of a closed-system drug transfer device (CSTD) on the release of doxorubicin was studied during administration via bolus injections. Methods: 10 administrations with the currently used technique and 10 administrations using the CSTD were compared by analysis of doxorubicin contamination on gauze pads, tissues and gloves. Findings: Using the current technique, contamination was found during nine administrations, which was mainly on the gauze pads and, to a lesser extent, on the tissues and gloves, indicating release of doxorubicin during administration. With use of the CSTD, contamination was found only on one pair of gloves. Conclusion: Use of a CSTD significantly decreased the number of spills and level of contamination compared with the currently used technique and, consequently, the use of such devices offers a safer working environment for nurses.

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