Frequency and component analysis of contaminants generated in preparation of anticancer agents using closed system drug transfer devices (CSTDs)

Occupational exposure of anticancer agents during their preparation has been recognized as a serious hazard. Closed system drug transfer devices (CSTDs) enable “safe” preparation of agents for medical personnel and ensure a safe hospital environment. However, artificial particles of infusion materials have been reported during CSTD use. Here, the incidence of insoluble fine particles during preparation of anticancer agents using CSTDs was examined. Visible insoluble fine particles were found in 465 (9.4%) of 4948 treatment cases at Ehime University Hospital with CSTD use. Contaminants occurred more frequently during preparation of monoclonal antibodies than cytotoxic anticancer agents (19.4% vs. 4.1%, respectively, P < 0.01). A similar survey was conducted at nine hospitals to investigate the incidence of insoluble fine particles with or without CSTDs. Insoluble fine particles were detected in 113 (15.4%) of 732 treatment cases during preparation of monoclonal antibodies with CSTD use. In contrast, the occurrence of insoluble fine particles without CSTDs was found in only 3 (0.073%) of 4113 treatment cases. Contamination with CSTDs might cause harmful effects on patients during cancer therapy. We strongly recommend the use of in-line filters combined with infusion routes after CSTD use to avoid contamination-associated adverse events.

Acid dissolution of neodymium magnet Nd-Fe-B in different conditions

The separation of rare-earth elements (REE) from a neodymium magnet has been widely studied last year. During the research it was identified that the waste of computer hard disk contains 25.41 % neodymium, 64.09 % iron, and <<1 % boron. To further isolate rare-earth metals, the magnet was acidically dissolved in open and closed systems. In both methods of dissolution, concentrated nitric acid was used. The difference between these methods is the conditions of dissolution of magnet. The magnet was dissolved in a microwave sample preparation system at different temperatures and pressures in a closed system. In the open system, the acid dissolution of the magnet is conducted at room temperature. 0.2 g of the neodymium magnet sample was taken under two conditions, and the dissolution process in the closed system lasted 1 hour, and in the open system 30-40 minutes. The open system is a non-laborious, simple, and cheap method of dissolving the magnet by comparing both systems. Therefore, an open sample preparation system is used for further work. To remove the iron in the magnet, oxalic acid was used and REEs are precipitated as oxalates under both conditions. According to the result of the Inductively coupled plasma mass spectrometry (ICP-MS) method, it was identified that the neodymium and iron contents in the precipitate are 24.66 % and 0.06 %, respectively. This shows that the iron has almost completely passed to the filtrate

Geochemical Evaluation of Formation Water, Mauddud Reservoir, Khabbaz Oilfield, Kirkuk Area, Northern Iraq

In this study, formation-water samples were collected by NOC Staff, during drilling time, from the Mauddud Formation reservoir of the Khabbaz Oilfield, for this reason four samples from four wells; Kz-3, Kz-4, Kz-7, and Kz-23 were selected to geochemical analysis. Analyzed geochemical parameters include TDS and the concentrations of the different dissolved cations and anions present in brines (Ca+2, Mg+2, Na+1, SO4-2, Cl-1, HCO3-1, and NaCl). Variations among the resulted data are discussed by comparison with other Cretaceous Brines. Geochemical ratios of Na/Cl, (Na-Cl)/SO4) and (Cl-Na)/Mg+2 was calculated for formation water classification following Bojarski, (1970). The calculated geochemical ratios of the studied samples in the studied four wells indicate that all of these waters are "chloride calcium" type under subsurface conditions, this type reflect closed system isolated associations reservoir, which are becoming high hydrostatic in deeper zones without influence by infiltration waters. A major transversal fault cutting the structure at its SE plunge had participated in the dilution of the Mauddud reservoir brine effectively.

The Depersonalized as Vanishing Hero and Heroine in Yorùbá Moral Placards

The paper critically examines the relationship between the idea of moral placards and the existence of Yorùbá heroes and heroines. It takes as its starting point the philosophical import of the Yoruba proverb. Ọjọ́ a bá kú là ń dère, èèyàn ò sunwọ̀n láàyè (It is on the day one dies that one becomes an idol; no one is appreciated when alive). The paper argues that in the imagination, reality, and social constructions of the Yorùbá, desirable existence would make the dead, and not a living person, a deity, hero or heroine. It further argues that because Yorùbá society permits the co-existence and co[1]extensiveness of individual and public moral placards which is not regarded as an entirely closed system, an otherwise depersonalized person can later become a hero/deity/heroine. Basically, therefore, public moral placard can be revised to accommodate new values, give rise to new class of people, and establish for them an enviable status. These arguments are then deployed to the understanding of the nature of heroes and heroines within the Nigerian post-independence polity.

Quantum Hydrodynamics of Spinning Particles in Electromagnetic and Torsion Fields

We develop a many-particle quantum-hydrodynamical model of fermion matter interacting with the external classical electromagnetic and gravitational/inertial and torsion fields. The consistent hydrodynamical formulation is constructed for the many-particle quantum system of Dirac fermions on the basis of the nonrelativistic Pauli-like equation obtained via the Foldy–Wouthuysen transformation. With the help of the Madelung decomposition approach, the explicit relations between the microscopic and macroscopic fluid variables are derived. The closed system of equations of quantum hydrodynamics encompasses the continuity equation, and the dynamical equations of the momentum balance and the spin density evolution. The possible experimental manifestations of the torsion in the dynamics of spin waves is discussed.

Nicolai Hartmann und die Gestalttheorie. Ein Vergleich unter dem Aspekt “Kausalität”

Summary In 1919 Nicolai Hartmann (NH) convincingly justified that there cannot exist a “general law of causation” as A. Meinong had in mind. For him Meinong’s understanding of causation (linear, successive in time) was bound on the region of the physical layer of being, simultaneously postulating it as the only possible causation there. This is the starting point of the comparison between N. Hartmann‘s understanding of causation and that of the Gestalt Theory, for which neither in psychic nor in natural (physical) context linear-successive causality plays a part. Therefore NH’s conception of 1919 was still completely incompatible with that of the Gestalt Theory despite the fact that he was distancing himself from the “general law of causation” sensu Meinong. 20 years later he changed this by adding the “Wechselwirkung” (interaction) to the linear successive causation in the physical layer. In doing so he approached the Gestalt theoretical position but failed it insofar as for it his linear-successive understanding of causation generally has had its day with regard to natural processes, also consequently for the physical (instead interaction between system and border conditions applies, an interaction of field forces). Thus the term “causation“ had become free for a dynamic concept of causation which is equally appropriate for the physical and the psychic. NH makes this move not until 1949, shortly before his death, by writing: ... (see original quotation in the German summary above). It is the opinion of the author of this work that the ingenious systematics of NH‘s Critical Ontology (which is not a closed system) should make it possible to execute the necessary corrections in some details of his theory of layers without questioning the structure of his systematics, thus carrying out what NH was not able to do himself due to his death.