scholarly journals Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans

2019 ◽  
Vol 103 ◽  
pp. 100-105 ◽  
Author(s):  
Samuel M. Cohen ◽  
Alan R. Boobis ◽  
Vicki L. Dellarco ◽  
John E. Doe ◽  
Penelope A. Fenner-Crisp ◽  
...  
1987 ◽  
Vol 26 (01) ◽  
pp. 13-23 ◽  
Author(s):  
H. W. Gottinger

AbstractThe purpose of this paper is to report on an expert system in design that screens for potential hazards from environmental chemicals on the basis of structure-activity relationships in the study of chemical carcinogenesis, particularly with respect to analyzing the current state of known structural information about chemical carcinogens and predicting the possible carcinogenicity of untested chemicals. The structure-activity tree serves as an index of known chemical structure features associated with carcinogenic activity. The basic units of the tree are the principal recognized classes of chemical carcinogens that are subdivided into subclasses known as nodes according to specific structural features that may reflect differences in carcinogenic potential among chemicals in the class. An analysis of a computerized data base of known carcinogens (knowledge base) is proposed using the structure-activity tree in order to test the validity of the tree as a classification scheme (inference engine).


Author(s):  
J Wright ◽  
S Randhawa ◽  
C Gooding ◽  
S Lowery ◽  
D Eastwood ◽  
...  

Venous thromboembolism (VTE) is widely understood to be an important cause both of morbidity and mortality in hospital inpatients. This has led to the development of guidelines for the management of VTE prophylaxis in adults by the national institute for Health and Clinical Excellence. In acknowledgement of the importance of this issue, there are government incentives in the form of Commissioning for Quality and innovation payments that are dependent on the performance of hospital trusts in certain quality indicators, such as risk assessment for VTE in the adult patient.


2019 ◽  
Vol 7 ◽  
Author(s):  
Matej Masár ◽  
Mária Hudáková

Current trends show that education in the field of project risk management is a very actual topic. Long - term projects, which was realized in 2018, was mainly focused on R&D across the world. Short - term projects, was focused on innovation and improve manufacturing processes. Many projects failed because project managers did not manage project risks. Project managers have less knowledge and skills on how to effectively manage project risks, especially risks in the planning phase of projects. The main aim of this article is to analyze the current state of usage project risk assessment across the world, based on own empirical research, which was provided, by authors in 2018 and 2019 (mainly level of usage project risk management methods, experience and level of education). The research focused on analyzing the current state of project risk assessment among continents. The authors focused on the average level of use qualitative and quantitative project risk analysis by project managers, level of project risk management experience by project managers and complexity of learning in using of qualitative and quantitative project risk management methods and tools.  Some recommendation were established to educate project managers in the field of project risk management.


2019 ◽  
Author(s):  
Scott T. Deneale ◽  
Gregory Baecher ◽  
Kevin M. Stewart ◽  
Ellen Smith ◽  
David Watson

Climate ◽  
2020 ◽  
Vol 8 (2) ◽  
pp. 33
Author(s):  
Tone Marie Olstad ◽  
Anne Apalnes Ørnhøi ◽  
Nina Kjølsen Jernæs ◽  
Lavinia de Ferri ◽  
Ashley Freeman ◽  
...  

During the Medieval period, over 1000 stave churches were thought to have been constructed in Norway. However, currently, only 28 of these churches remain and only 19 still have distemper wall paintings. The cultural significance of these structures, and more specifically their elaborate distemper wall paintings, has changed over time, as have the means and methods for preserving these monuments. Deeper knowledge of the current state of these structures, along with environmental monitoring and modeling will open the way to a better understanding of preservation. This paper presents a case study for unheated Norwegian wooden churches based on data collected from Kvernes stave church. There are three aims for this paper: (i) to describe the typical indoor conditions similar to the historic climate of stave churches; (ii) determine the common characteristics of distemper paint found within stave churches; (iii) and develop a risk assessment tool to evaluate the climate-induced risk factors in stave churches. The outcome of this work will contribute to research performed within the Sustainable Management of Heritage Buildings in a Long-term Perspective (SyMBoL) project which aims to develop a better understanding of climate induced risks for stave churches, and ultimately to better manage environmental risk.


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