Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane: Transcriptional regulation

1996 ◽  
Vol 175 (4) ◽  
pp. 1057-1065 ◽  
Author(s):  
Stephen J. Fortunato ◽  
Ramkumar Menon ◽  
Kenneth F. Swan ◽  
Salvatore J. Lombardi
Keyword(s):  
Transcriptional Regulation ◽  
Interleukin 6 ◽  
Interleukin 10

Suppression of interleukin-6 to interleukin-10 ratio in chronic alcoholics: association with postoperative infections

2002 ◽  
Vol 28 (3) ◽  
pp. 285-292 ◽  
Author(s):  
M. Sander ◽  
M. Irwin ◽  
P. Sinha ◽  
E. Naumann ◽  
W. Kox ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Interleukin 10 ◽  
Postoperative Infections

scholarly journals Interleukin-6-induced Tethering of STAT3 to the LAP/C/EBPβ Promoter Suggests a New Mechanism of Transcriptional Regulation by STAT3

2000 ◽  
Vol 276 (12) ◽  
pp. 9016-9027 ◽  
Author(s):  
Monika Niehof ◽  
Konrad Streetz ◽  
Tim Rakemann ◽  
Stephan C. Bischoff ◽  
Michael P. Manns ◽  
...  
Keyword(s):  
Transcriptional Regulation ◽  
Interleukin 6

scholarly journals Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level

1993 ◽  
Vol 13 (1) ◽  
pp. 276-288
Author(s):  
U M Wegenka ◽  
J Buschmann ◽  
C Lütticken ◽  
P C Heinrich ◽  
F Horn
Keyword(s):  
Transcriptional Regulation ◽  
Acute Phase ◽  
Interleukin 6 ◽  
Acute Phase Response ◽  
Acute Phase Protein ◽  
Phase Response ◽  
Response Factor ◽  
Nuclear Factor ◽  
Response Elements ◽  
Phase Protein

Interleukin-6 (IL-6) is known to be a major mediator of the acute-phase response in liver. We show here that IL-6 triggers the rapid activation of a nuclear factor, termed acute-phase response factor (APRF), both in rat liver in vivo and in human hepatoma (HepG2) cells in vitro. APRF bound to IL-6 response elements in the 5'-flanking regions of various acute-phase protein genes (e.g., the alpha 2-macroglobulin, fibrinogen, and alpha 1-acid glycoprotein genes). These elements contain a characteristic hexanucleotide motif, CTGGGA, known to be required for the IL-6 responsiveness of these genes. Analysis of the binding specificity of APRF revealed that it is different from NF-IL6 and NF-kappa B, transcription factors known to be regulated by cytokines and involved in the transcriptional regulation of acute-phase protein genes. In HepG2 cells, activation of APRF was observed within minutes after stimulation with IL-6 or leukemia-inhibitory factor and did not require ongoing protein synthesis. Therefore, a preexisting inactive form of APRF is activated by a posttranslational mechanism. We present evidence that this activation occurs in the cytoplasm and that a phosphorylation is involved. These results lead to the conclusions that APRF is an immediate target of the IL-6 signalling cascade and is likely to play a central role in the transcriptional regulation of many IL-6-induced genes.

Interleukin-10, interleukin-6 and interferon-γ gene polymorphisms in melanoma patients

2002 ◽  
Vol 12 (5) ◽  
pp. 465-469 ◽  
Author(s):  
J. A. Martínez-Escribano ◽  
M. R. Moya-Quiles ◽  
M. Muro ◽  
O. Montes-Ares ◽  
T. Hernández-Caselles ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Gene Polymorphisms ◽  
Interleukin 10 ◽  
Interferon Γ ◽  
Melanoma Patients

scholarly journals Comparative insights into the regulation of inflammation: Levels and predictors of interleukin 6 and interleukin 10 in young adults in the Philippines

2011 ◽  
Vol 146 (3) ◽  
pp. 373-384 ◽  
Author(s):  
Thomas W. McDade ◽  
Paula S. Tallman ◽  
Linda S. Adair ◽  
Judith Borja ◽  
Christopher W. Kuzawa
Keyword(s):  
Young Adults ◽  
Interleukin 6 ◽  
Interleukin 10 ◽  
The Philippines
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