Spontaneous regression of retinal astrocytic hamartoma in a patient with tuberous sclerosis

AbstractCardiac rhabdomyomas are the most common tumours in children and are typically seen in association with the tuberous sclerosis complex. Although benign and often associated with spontaneous regression, in rare circumstances surgical resection is indicated to relieve obstruction or other mass-related effects. Recent clinical trials have demonstrated the benefits of mammalian target of rapamycin inhibitors for the treatment of other tumour sub-types associated with tuberous sclerosis. Here we report rapid regression of several massive cardiac rhadomyomas in two neonates with the use of the mammalian target of rapamycin inhibitor sirolimus.

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Everolimus to treat aggressive retinal astrocytic hamartoma in tuberous sclerosis complex

Journal of American Association for Pediatric Ophthalmology and Strabismus ◽

10.1016/j.jaapos.2017.04.012 ◽

2017 ◽

Vol 21 (4) ◽

pp. 328-331 ◽

Cited By ~ 9

Author(s):

Nambi Nallasamy ◽

Michael I. Seider ◽

Sridharan Gururangan ◽

Prithvi Mruthyunjaya

Keyword(s):

Tuberous Sclerosis ◽

Tuberous Sclerosis Complex ◽

Astrocytic Hamartoma

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Large symptomatic retinal astrocytic hamartoma in a child with tuberous sclerosis complex

Saudi Journal of Ophthalmology ◽

10.1016/j.sjopt.2017.09.002 ◽

2017 ◽

Vol 31 (4) ◽

pp. 280-281 ◽

Cited By ~ 2

Author(s):

Neha Goel

Keyword(s):

Tuberous Sclerosis ◽

Tuberous Sclerosis Complex ◽

Astrocytic Hamartoma

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SPONTANEOUS REGRESSION OF PARAFOVEAL EXUDATES AND SEROUS RETINAL DETACHMENT IN A PATIENT WITH TUBEROUS SCLEROSIS AND RETINAL ASTROCYTOMAS

Retina ◽

10.1097/00006982-198400440-00005 ◽

1984 ◽

Vol 4 (4) ◽

pp. 242-245 ◽

Cited By ~ 15

Author(s):

GREGORY J. PANZO ◽

SANFORD M. MEYERS ◽

FRONCIE A. GUTMAN ◽

CAROL R. KOLLARITS ◽

RICHARD J. LEDERMAN

Keyword(s):

Retinal Detachment ◽

Tuberous Sclerosis ◽

Spontaneous Regression ◽

Serous Retinal Detachment

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Retinal Nerve Fiber Layer Defect Associated with Astrocytic Hamartoma in a Patient with Tuberous Sclerosis

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2013.54.8.1282 ◽

2013 ◽

Vol 54 (8) ◽

pp. 1282 ◽

Cited By ~ 1

Author(s):

Ka Hyun Lee ◽

Naeun Lee ◽

Chang Kyu Lee ◽

Sa Min Hong ◽

Gong Je Seong ◽

...

Keyword(s):

Tuberous Sclerosis ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Layer Defect ◽

Nerve Fiber Layer Defect ◽

Astrocytic Hamartoma ◽

Retinal Nerve Fiber

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Astrocytic Hamartoma of the Retina Not Associated with Tuberous Sclerosis

American Journal of Ophthalmology ◽

10.1016/0002-9394(78)90192-7 ◽

1978 ◽

Vol 86 (5) ◽

pp. 688-698 ◽

Cited By ~ 39

Author(s):

Frederick H. Reeser ◽

Thomas M. Aaberg ◽

Diane L. Van Horn

Keyword(s):

Tuberous Sclerosis ◽

Astrocytic Hamartoma

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Spontaneous Regression of Cardiac Rhabdomyoma Presenting as Severe Left Ventricular Inlet Obstruction in a Neonate with Tuberous Sclerosis

Case Reports in Cardiology ◽

10.1155/2018/8395260 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Eun Song Song ◽

Kumi Jeong ◽

Gun Kim ◽

In Ji Hwang ◽

Mi-Ji Lee ◽

...

Keyword(s):

Conservative Treatment ◽

Tuberous Sclerosis ◽

Spontaneous Regression ◽

Surgical Intervention ◽

Left Ventricular ◽

Onset Age ◽

Cardiac Rhabdomyoma ◽

Emergency Intervention

Cardiac rhabdomyoma can be subclinical or have a fatal presentation according to the onset age and involved site, size, and degree of invasion. Although most cardiac rhabdomyomas become smaller with time, emergency intervention is indicated when severe obstruction has occurred. In this report, we describe the spontaneous regression of a large cardiac rhabdomyoma (20.5 × 15.6 mm) presenting as severe left ventricular inlet obstruction in a neonate with tuberous sclerosis. Although a cardiac rhabdomyoma can be large enough to induce left ventricular inlet obstruction, conservative treatment without aggressive surgical intervention can be considered if the hemodynamic condition does not deteriorate.

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