Histamine ZO-1 and blood-retinal barrier permeability in diabetic retinopathy

1996 ◽  
Vol 121 (1) ◽  
pp. 114
Author(s):  
TW Gardner
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Retinal Barrier ◽  
Barrier Permeability

Effect of morphological abnormalities on blood retinal barrier permeability in diabetic retinopathy

1992 ◽  
Vol 80 (2) ◽  
pp. 183-188 ◽  
Author(s):  
Johannes M. A. Van Gerven ◽  
Johan P. Boot ◽  
Herman H. P. J. Lemkes ◽  
Jaap A. Van Best
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Retinal Barrier ◽  
Barrier Permeability ◽  
Morphological Abnormalities

Mechanistic Insights into Immunological Therapy for Targeting Diabetic Retinopathy

2021 ◽  
Vol 5 (3) ◽  
pp. 01-05
Author(s):  
Imteyaz Qamar
Keyword(s):  
Diabetic Retinopathy ◽  
Progressive Disease ◽  
Common Complication ◽  
Blood Retinal Barrier ◽  
Immunological Therapy ◽  
Tnf Α ◽  
Capillary Occlusion ◽  
Inflammatory Molecules ◽  
Inflammatory Effect

Diabetic retinopathy (DR) is a common complication amongst patients that have diabetes. It is a leading cause of blindness in middle age people. A large proportion of patients who have diabetes develop retinopathy. There are several immunological reasons associated with the pathophysiology of this disease. Role of several mediators that increase the oxidative stress and have a pro-inflammatory effect which leads to capillary occlusion and neovascularization (NV). Increased vasopermeability due to disruption of the blood-retinal barrier (BRB) leading to diabetic macular edema (DME). Immunotherapies utilise different compounds and target various inflammatory molecules like TNF-α and pathways such as PPARγ for treatment of this progressive disease. Inflammatory and pro-inflammatory pathways are found to have an essential role in promoting DR; therefore, targeting them provides a useful technique for curing DR.

Erythropoietin protects outer blood‐retinal barrier in experimental diabetic retinopathy by up‐regulating ZO‐1 and occludin

2019 ◽  
Vol 47 (9) ◽  
pp. 1182-1197 ◽  
Author(s):  
Chaoyang Zhang ◽  
Hai Xie ◽  
Qian Yang ◽  
Yiting Yang ◽  
Weiye Li ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Retinal Barrier

scholarly journals A Potential Role for Angiopoietin 2 in the Regulation of the Blood–Retinal Barrier in Diabetic Retinopathy

2011 ◽  
Vol 52 (6) ◽  
pp. 3784 ◽  
Author(s):  
Sampathkumar Rangasamy ◽  
Ramprasad Srinivasan ◽  
Joann Maestas ◽  
Paul G. McGuire ◽  
Arup Das
Keyword(s):  
Diabetic Retinopathy ◽  
Potential Role ◽  
Blood Retinal Barrier ◽  
Angiopoietin 2

scholarly journals Erythropoietin protects the inner blood–retinal barrier by inhibiting microglia phagocytosis via Src/Akt/cofilin signalling in experimental diabetic retinopathy

Diabetologia ◽  
2020 ◽  
Vol 64 (1) ◽  
pp. 211-225
Author(s):  
Hai Xie ◽  
Chaoyang Zhang ◽  
Dandan Liu ◽  
Qian Yang ◽  
Lei Tang ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Blood Retinal Barrier
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