Evaluation of natural computation techniques in the modelling and optimization of a sequential injection flow system for colorimetric iron(III) determination

Abstract A selective and sensitive method based on coupling of sequential injection analysis (SIA) and optosensing was developed and applied to the determination of indomethacin in pharmaceutical and urinary samples. After alkaline hydrolysis, the fluorescent product generated from indomethacin is inserted in the flow system, transitorily retained on an active solid support (Sephadex QAE A-25) filling the flowcell, and monitored at 283/371 nm (λex/λem). The system was calibrated for two sample volumes, 100 and 1000 µL. It showed a linear dynamic range of 0.56.5 ng/mL, with an LOD of 0.15 ng/mL and an RSD of 3.9% (n = 10) when the highest sample volume was used. The proposed fluorometric SIA optosensor was applied to the determination of indomethacin in both pharmaceuticals and urine samples, and satisfactory results were obtained.

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Using Sequential Injection Analysis to Improve System and Data Reliability of Online Methods: Determination of Ammonium and Phosphate in Coastal Waters

Journal of Automated Methods and Management in Chemistry ◽

10.1155/2007/49535 ◽

2007 ◽

Vol 2007 ◽

pp. 1-6 ◽

Cited By ~ 10

Author(s):

Carsten Frank ◽

Friedhelm Schroeder

Keyword(s):

Coastal Waters ◽

Method Development ◽

Flow System ◽

Sequential Injection Analysis ◽

Sequential Injection ◽

Method Development And Validation ◽

Standard Additions ◽

Online Methods ◽

Development And Validation

This article summarises the advantages of the sequential injection analysis (SIA) for the online determination of nutrients in coastal waters. It concentrates on techniques to improve the reliability of the gained data by continuously monitoring one or more standards and on the advantages of online standard additions and offline determination of manually collected samples with the online SIA system. These measures are advantageous during method development and validation and can be used to verify the system performance on a regular base to reduce the amount of erroneous results. No changes in the flow system are necessary and the sample throughput is only slightly reduced. These techniques have been applied to a SIA system which is able to simultaneously determine ammonium and phosphate at a rate of more than 100 samples per hour each and detection limits (3σ) of 0.06μM and 0.05μM. Results from a campaign in summer 2005 are shown.

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A pulsed sequential injection analysis flow system for the fluorimetric determination of indomethacin in pharmaceutical preparations

Analytica Chimica Acta ◽

10.1016/j.aca.2005.03.037 ◽

2005 ◽

Vol 539 (1-2) ◽

pp. 173-179 ◽

Cited By ~ 22

Author(s):

Paula C.A.G. Pinto ◽

M. Lúcia M.F.S. Saraiva ◽

João L.M. Santos ◽

José L.F.C. Lima

Keyword(s):

Flow System ◽

Pharmaceutical Preparations ◽

Sequential Injection Analysis ◽

Sequential Injection ◽

Fluorimetric Determination

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Application of natural computation techniques to optimal design of flow injection systems

Analytica Chimica Acta ◽

10.1016/s0003-2670(99)00528-0 ◽

1999 ◽

Vol 402 (1-2) ◽

pp. 275-283 ◽

Cited By ~ 2

Author(s):

J. de Gracia ◽

A. Araujo ◽

J.L.F.C. Lima ◽

I. Villaescusa ◽

M. Poch

Keyword(s):

Optimal Design ◽

Flow Injection ◽

Computation Techniques ◽

Natural Computation

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Determination of acid phosphatase activity in a double injection flow system with electrochemical detection

Analytica Chimica Acta ◽

10.1016/s0003-2670(99)00772-2 ◽

2000 ◽

Vol 406 (2) ◽

pp. 225-232 ◽

Cited By ~ 8

Author(s):

J Castañón-Fernández ◽

M.T Fernández-Abedul ◽

A Costa-Garcı́a

Keyword(s):

Acid Phosphatase ◽

Phosphatase Activity ◽

Electrochemical Detection ◽

Acid Phosphatase Activity ◽

Flow System ◽

Double Injection ◽

Injection Flow

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Utilização dos métodos automáticos em fluxos com detecção espectrofotométrica na determinação de diclofenaco de sódio em formulações farmacêuticas e fluidos corporais

Revista Colombiana de Ciencias Químico Farmacéuticas ◽

10.15446/rcciquifa.v48n1.80063 ◽

2019 ◽

Vol 48 (1) ◽

pp. 29-43

Author(s):

Paulo Roberto Barrros Gomes ◽

Victor Elias Mouchrek Filho ◽

Rayone Wesly Santos de Oliveira ◽

Adriana Pereira Everton ◽

Jonas Batista Reis ◽

...

Keyword(s):

Spectrophotometric Determination ◽

Spectrophotometric Method ◽

Flow System ◽

Diclofenac Sodium ◽

Pharmaceutical Preparations ◽

Pharmaceutical Formulations ◽

Sequential Injection Analysis ◽

Sequential Injection ◽

Para Determinar

Este trabalho descreveu e comparou quatro estudos entre si que utilizaram métodos automáticos em fluxo com detecção espectrofotométrica e a reação de oxidação do diclofenaco para determinar diclofenaco em formulações farmacêuticas e fluidos corporais. Para isso, utilizamos os seguintes artigos: Versatility of a multicommuted flow system in the spectrometric determination of three analytes, Sequential injection spectrophotometric method for the assay of anti-inflammatory diclofenac sodium in pharmaceutical preparations, Screening of conditions controlling spectrophotometric sequential injection analysis e Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations e detalhamos as metodologias empregadas, os resultados, conclusões obtidas e comparamos entre eles os limites de detecção, desvio padrão relativo e a frequência analítica. Os resultados mostraram diferenças significativas entre métodos empregados e a utilização do Sistema automático do tipo Análise por Injeção Sequencial, apesar deste possuir menor frequência analítica.

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