scholarly journals Utilização dos métodos automáticos em fluxos com detecção espectrofotométrica na determinação de diclofenaco de sódio em formulações farmacêuticas e fluidos corporais

2019 ◽  
Vol 48 (1) ◽  
pp. 29-43
Author(s):  
Paulo Roberto Barrros Gomes ◽  
Victor Elias Mouchrek Filho ◽  
Rayone Wesly Santos de Oliveira ◽  
Adriana Pereira Everton ◽  
Jonas Batista Reis ◽  
...  
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Flow System ◽  
Diclofenac Sodium ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Sequential Injection Analysis ◽  
Sequential Injection ◽  
Para Determinar

Este trabalho descreveu e comparou quatro estudos entre si que utilizaram métodos automáticos em fluxo com detecção espectrofotométrica e a reação de oxidação do diclofenaco para determinar diclofenaco em formulações farmacêuticas e fluidos corporais. Para isso, utilizamos os seguintes artigos: Versatility of a multicommuted flow system in the spectrometric determination of three analytes, Sequential injection spectrophotometric method for the assay of anti-inflammatory diclofenac sodium in pharmaceutical preparations, Screening of conditions controlling spectrophotometric sequential injection analysis e Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations e detalhamos as metodologias empregadas, os resultados, conclusões obtidas e comparamos entre eles os limites de detecção, desvio padrão relativo e a frequência analítica. Os resultados mostraram diferenças significativas entre métodos empregados e a utilização do Sistema automático do tipo Análise por Injeção Sequencial, apesar deste possuir menor frequência analítica.

scholarly journals Eco- Friendly Ultraviolet Spectrophotometric Determination of Allopurinol in Pharmaceutical Preparations and Environmental Wastewater Samples: Application to Content Uniformity Testing

2021 ◽  
pp. 1-3
Author(s):  
Nief Rahman Ahmed ◽  
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Industrial Wastewater ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Content Uniformity ◽  
Distilled Water ◽  
Content Uniformity Testing ◽  
Wastewater Samples

A simple, economical and sensitive UV spectrophotometric method has been developed for the determination of allopurinol in environmental wastewater samples and, pharmaceutical preparations which shows maximum absorbance at 250 nm in distilled water. Beer’s law was obeyed in the range of 1 - 20 μg/ ml, with molar absorptive of 0.628 x104 l/mol.cm L.mol-1.cm-1 .The method was successfully applied to the determination of allopurinol in some pharmaceutical formulations (tablets) and industrial wastewater samples. The proposed method was validated by sensitivity and precision which proves suitability for the routine analysis of allopurinol in true samples.

scholarly journals Simple UV Spectrophotometric Determination of Rosuvastatin Calcium in Pure Form and in Pharmaceutical Formulations

2009 ◽  
Vol 6 (1) ◽  
pp. 89-92 ◽  
Author(s):  
Alka Gupta ◽  
P. Mishra ◽  
K. Shah
Keyword(s):  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pure Form ◽  
Ultraviolet Region ◽  
Rosuvastatin Calcium ◽  
Sensitive Spectrophotometric Method

A new, simple and sensitive spectrophotometric method in ultraviolet region has been developed for the determination of rosuvastatin calcium in bulk and in pharmaceutical formulations. Rosuvastatin exhibits absorption maxima at 244 nm with apparent molar absorptivity of 7.2345 ×104L/mol.cm in methanol. Beer’s law was found to be obeyed in the concentration range of 2-18 µg/mL. The method is accurate, precise and economical. This method is extended to pharmaceutical preparations. In this method, there is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated statistically and by recovery studies

scholarly journals Spectrophotometric determination of Valsartan in pure form and in its pharmaceutical preparations

2021 ◽  
Vol 26 (4) ◽  
Author(s):  
Qabas Rashid ◽  
Ruwaida Farman Salih
Keyword(s):  
Correlation Coefficient ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Limit Of Detection ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Molar Absorptivity ◽  
Pure Form ◽  
Chromogenic Reagent

An easy, rapid and economical spectrophotometric method for  determination of  Valsartan (Val), by reaction with 4-chloro-7-nitrobenzofurazan (NBD-Cl) as reagent in an alkaline interemediate. This method is based on the forming of product between (Val) and the chromogenic reagent (NBD-Cl), to produce a brown color at (pH 11.9) and λmax. 470 nm.  Beer’s Law is obeyed at the concentrations range of (0.4-14.8 µg/ml), with molar absorptivity of (1.05×104 L/mol.cm) and correlation coefficient 0.9827, The limit of detection was 0.557 µg/ml. The suggested method was prosperity implement to the determination of (Val) in  pure form and in its pharmaceutical formulations (tablets).

scholarly journals Spectrophotometric Determination of Epinephrine in Pharmaceutical Preparations Using Praseodymium as Mediating Metals

2011 ◽  
Vol 8 (1) ◽  
pp. 110-117 ◽  
Author(s):  
Baghdad Science Journal
Keyword(s):  
Relative Error ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Direct Methods ◽  
Orange Yellow ◽  
Sensitive Spectrophotometric Method

A simple, accurate and sensitive spectrophotometric method for the determinaion of epinephrine is described . The method is based on the coordination of Pr (III) with epinephrine at pH 6. Absorbance of the resulting orange yellow complex is measured at 482 nm . A graph of absorbance versus concentrations shows that beer 's low is obeyed over the concentration range (1-50)mg.ml-1 of epinephrine with molar absorpitivity of ( 2.180x103 L.mol-1.cm-1 ), a sandell sensitivity of (0.084 mg.cm-2 ), a relative error of (-2.83%) , a corrolation coffecient (r= 0.9989) and recovery % ( 97.03 ± 0.75 ) depending on the concentration.This method is applied to analyse EP in several commercially available pharmaceutical preparations using direct methods .All statistical calculations are implemented via a Minitab software version 11.

scholarly journals Spectrophotometric Determination ofN-Acetyl-L-Cysteine andN-(2-Mercaptopropionyl)-Glycine in Pharmaceutical Preparations

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Lea Kukoc-Modun ◽  
Njegomir Radić
Keyword(s):  
Regression Analysis ◽  
Detection Limit ◽  
Correlation Coefficient ◽  
Spectrophotometric Determination ◽  
Spectrophotometric Method ◽  
Pharmaceutical Preparations ◽  
Complexation Reaction ◽  
Calibration Data ◽  
Pharmaceutical Excipients

A simple spectrophotometric method for the determination ofN-acetyl-L-cysteine (NAC) andN-(2-mercaptopropionyl)glycine (MPG) in pharmaceutical preparations was developed, validated, and used. The proposed equilibrium method is based on a coupled two-step redox and complexation reaction. In the first step, Fe(III) is reduced to Fe(II) by NAC or MPG. Subsequently, Fe(II) is complexed with 2,4,6-tripyridyl-s-triazine (TPTZ). Several analytical parameters of the method were optimized for NAC and MPG analysis in the concentration range from 1.0 μM to 100.0 μM. Regression analysis of the calibration data showed a good correlation coefficient (0.9999). The detection limit of the method was 0.14 μM for NAC and 0.13 μM for MPG. The method was successfully applied to quantify NAC and MPG in pharmaceutical preparations. No interferences were observed from common pharmaceutical excipients.

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