scholarly journals The Link between Ion Permeation and Inactivation Gating of Kv4 Potassium Channels

2003 ◽  
Vol 84 (2) ◽  
pp. 928-941 ◽  
Author(s):  
Mohammad Shahidullah ◽  
Manuel Covarrubias
Keyword(s):  
Potassium Channels ◽  
Ion Permeation ◽  
Inactivation Gating

Use of voltage clamp fluorimetry in understanding potassium channel gating: a review of Shaker fluorescence data

2009 ◽  
Vol 87 (6) ◽  
pp. 411-418 ◽  
Author(s):  
A.J. Horne ◽  
D. Fedida
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Voltage Clamp ◽  
Channel Gating ◽  
Specific Protein ◽  
Channel Activation ◽  
Shaker Potassium Channel ◽  
Inactivation Gating ◽  
Nanosecond Time Resolution ◽  
Shaker Potassium Channels

Voltage clamp fluorimetry (VCF) utilizes fluorescent probes that covalently bind to cysteine residues introduced into proteins and emit light as a function of their environment. Measurement of this emitted light during membrane depolarization reveals changes in the emission level as the environment of the labelled residue changes. This allows for the correlation of channel gating events with movement of specific protein moieties, at nanosecond time resolution. Since the pioneering use of this technique to investigate Shaker potassium channel activation movements, VCF has become an invaluable technique used to understand ion channel gating. This review summarizes the theory and some of the data on the application of the VCF technique. Although its usage has expanded beyond voltage-gated potassium channels and VCF is now used in a number of other voltage- and ligand-gated channels, we will focus on studies conducted in Shaker potassium channels, and what they have told us about channel activation and inactivation gating.

scholarly journals Structural Basis For The Coupling Between Activation And Inactivation Gating In Potassium Channels

2009 ◽  
Vol 96 (3) ◽  
pp. 381a ◽  
Author(s):  
Luis G. Cuello ◽  
Vishwanath Jogini ◽  
D. Marien Cortes ◽  
Albert C. Pan ◽  
Dominique G. Gagnon ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Structural Basis ◽  
Inactivation Gating

scholarly journals Regulation of ion Permeation in the Selectivity Filter of Potassium Channels

2014 ◽  
Vol 106 (2) ◽  
pp. 234a
Author(s):  
Simon Berneche ◽  
Wojciech Wojtas-Niziurski ◽  
Florian Heer
Keyword(s):  
Potassium Channels ◽  
Selectivity Filter ◽  
Ion Permeation

scholarly journals Targeting potassium channels in cancer

2014 ◽  
Vol 206 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Xi Huang ◽  
Lily Yeh Jan
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Cancer Therapeutics ◽  
Ion Permeation ◽  
Cell Behaviors ◽  
Independent Functions ◽  
Channel Expression ◽  
Surface Localization ◽  
Cell Surface Localization ◽  
And Migration

Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. Aberrant potassium channel functions contribute to diseases such as epilepsy, cardiac arrhythmia, and neuromuscular symptoms collectively known as channelopathies. Increasing evidence suggests that cancer constitutes another category of channelopathies associated with dysregulated channel expression. Indeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.

scholarly journals Ion Permeation Efficiency through Potassium Channels

2014 ◽  
Vol 106 (2) ◽  
pp. 539a
Author(s):  
David A. Kopfer ◽  
Chen Song ◽  
Ulrich Zachariae ◽  
Bert L. de Groot
Keyword(s):  
Potassium Channels ◽  
Ion Permeation

scholarly journals Molecular Simulations of Ion Permeation in Potassium Channels

2017 ◽  
Vol 112 (3) ◽  
pp. 163a
Author(s):  
Wojciech Kopec ◽  
Bert de Groot
Keyword(s):  
Potassium Channels ◽  
Molecular Simulations ◽  
Ion Permeation

scholarly journals Ion Permeation in Potassium Channels Involves Direct Coulomb Knock-On between Ions

2015 ◽  
Vol 108 (2) ◽  
pp. 118a
Author(s):  
Ulrich Zachariae ◽  
David A. Kopfer ◽  
Chen Song ◽  
Tim Gruene ◽  
George M. Sheldrick ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Ion Permeation
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