Effects of prenatal exposure to ethanol on callosal projection neurons in rat somatosensory cortex

1997 ◽  
Vol 766 (1-2) ◽  
pp. 121-128 ◽  
Author(s):  
Michael W Miller
1989 ◽  
Vol 282 (3) ◽  
pp. 428-445 ◽  
Author(s):  
Herbert P. Killackey ◽  
Katherine-Ann Koralek ◽  
Nicholas L. Chiaia ◽  
Robert W. Rhoades

2009 ◽  
Vol 65 ◽  
pp. S212
Author(s):  
Sachie Sasaki-Hamada ◽  
Yasuhiro Tanaka ◽  
Yasuyo Tanaka ◽  
Jun-ichiro Oka ◽  
Takeshi Kaneko

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Kawssar Harb ◽  
Elia Magrinelli ◽  
Céline S Nicolas ◽  
Nikita Lukianets ◽  
Laura Frangeul ◽  
...  

During cortical development, the identity of major classes of long-distance projection neurons is established by the expression of molecular determinants, which become gradually restricted and mutually exclusive. However, the mechanisms by which projection neurons acquire their final properties during postnatal stages are still poorly understood. In this study, we show that the number of neurons co-expressing Ctip2 and Satb2, respectively involved in the early specification of subcerebral and callosal projection neurons, progressively increases after birth in the somatosensory cortex. Ctip2/Satb2 postnatal co-localization defines two distinct neuronal subclasses projecting either to the contralateral cortex or to the brainstem suggesting that Ctip2/Satb2 co-expression may refine their properties rather than determine their identity. Gain- and loss-of-function approaches reveal that the transcriptional adaptor Lmo4 drives this maturation program through modulation of epigenetic mechanisms in a time- and area-specific manner, thereby indicating that a previously unknown genetic program postnatally promotes the acquisition of final subtype-specific features.


2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S186-S186
Author(s):  
Peter Herman ◽  
Shaun A Wahab ◽  
Andras Eke ◽  
Fahmeed Hyder

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