Corpus Callosum Damage and InterhemispherIc Transfer of Information following Closed Head Injury in Children

Cortex ◽  
1999 ◽  
Vol 35 (3) ◽  
pp. 315-336 ◽  
Author(s):  
Debra A. Benavidez ◽  
Jack M. Fletcher ◽  
H. Julia Hannay ◽  
Sondra T. Bland ◽  
Susan E. Caudle ◽  
...  
Keyword(s):  
Head Injury ◽  
Corpus Callosum ◽  
Closed Head Injury ◽  
Interhemispheric Transfer ◽  
Closed Head ◽  
Transfer Of Information

Interhemispheric transfer after spontaneous recovery in 43 cases of severe closed head injury.

1989 ◽  
Vol 3 (2) ◽  
pp. 91-102 ◽  
Author(s):  
Claude M. Braun ◽  
Jacinthe M. Baribeau ◽  
Marie Ethier
Keyword(s):  
Head Injury ◽  
Spontaneous Recovery ◽  
Closed Head Injury ◽  
Interhemispheric Transfer ◽  
Closed Head

Corpus callosum lesions after closed head injury in children: MRI, clinical features and outcome

1992 ◽  
Vol 34 (5) ◽  
pp. 384-388 ◽  
Author(s):  
D. B. Mendelsohn ◽  
H. S. Levin ◽  
H. Harward ◽  
D. Bruce
Keyword(s):  
Head Injury ◽  
Corpus Callosum ◽  
Clinical Features ◽  
Closed Head Injury ◽  
Closed Head

scholarly journals Traumatic Brain Injury by a Closed Head Injury Device Induces Cerebral Blood Flow Changes and Microhemorrhages

2015 ◽  
Vol 5 ◽  
pp. 52 ◽  
Author(s):  
Srinivasu Kallakuri ◽  
Sharath Bandaru ◽  
Nisrine Zakaria ◽  
Yimin Shen ◽  
Zhifeng Kou ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Brain Injury ◽  
Head Injury ◽  
Corpus Callosum ◽  
Closed Head Injury ◽  
Susceptibility Weighted Imaging ◽  
Closed Head ◽  
Flow Changes

Objectives: Traumatic brain injury is a poly-pathology characterized by changes in the cerebral blood flow, inflammation, diffuse axonal, cellular, and vascular injuries. However, studies related to understanding the temporal changes in the cerebral blood flow following traumatic brain injury extending to sub-acute periods are limited. In addition, knowledge related to microhemorrhages, such as their detection, localization, and temporal progression, is important in the evaluation of traumatic brain injury. Materials and Methods: Cerebral blood flow changes and microhemorrhages in male Sprague Dawley rats at 4 h, 24 h, 3 days, and 7 days were assessed following a closed head injury induced by the Marmarou impact acceleration device (2 m height, 450 g brass weight). Cerebral blood flow was measured by arterial spin labeling. Microhemorrhages were assessed by susceptibility-weighted imaging and Prussian blue histology. Results: Traumatic brain injury rats showed reduced regional and global cerebral blood flow at 4 h and 7 days post-injury. Injured rats showed hemorrhagic lesions in the cortex, corpus callosum, hippocampus, and brainstem in susceptibility-weighted imaging. Injured rats also showed Prussian blue reaction products in both the white and gray matter regions up to 7 days after the injury. These lesions were observed in various areas of the cortex, corpus callosum, hippocampus, thalamus, and midbrain. Conclusions: These results suggest that changes in cerebral blood flow and hemorrhagic lesions can persist for sub-acute periods after the initial traumatic insult in an animal model. In addition, microhemorrhages otherwise not seen by susceptibility-weighted imaging are present in diverse regions of the brain. The combination of altered cerebral blood flow and microhemorrhages can potentially be a source of secondary injury changes following traumatic brain injury and may need to be taken into consideration in the long-term care of these cases.

Corpus callosal atrophy following closed head injury: detection with magnetic resonance imaging

1990 ◽  
Vol 73 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Harvey S. Levin ◽  
David H. Williams ◽  
Michael Valastro ◽  
Howard M. Eisenberg ◽  
Marsha J. Crofford ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Head Injury ◽  
Magnetic Resonance ◽  
Corpus Callosum ◽  
Diffuse Axonal Injury ◽  
Closed Head Injury ◽  
Magnetic Resonance Images ◽  
Resonance Imaging ◽  
Minimum Width ◽  
Closed Head

✓ To investigate evidence for diffuse white matter injury and hemispheric disconnection sequelae after severe closed head injury (CHI), this study evaluates the degree of posttraumatic atrophy of the corpus callosum. Corpus callosal atrophy was quantitatively determined using a digitizer to measure sagittal magnetic resonance images of 32 patients with moderate-to-severe CHI and those of 31 control subjects of similar age. In the CHI patients, measurements were significantly reduced for the areas of the anterior four-fifths, the posterior one-fifth, and the total corpus callosum. Moreover, the minimum width of the callosal body was reduced in the CHI patients as compared to that of control individuals. Indices of corpus callosal atrophy were significantly correlated with the chronicity of injury and the degree of lateral ventricular enlargement. There was no difference in callosal measurements between men and women. Magnetic resonance imaging provides an in vivo determination of corpus callosal atrophy which may reflect the severity of diffuse axonal injury and predict the type and severity of hemispheric disconnection effects.

The Management of Minor Closed Head Injury in Children

PEDIATRICS ◽  
2000 ◽  
Vol 106 (6) ◽  
pp. 1524-1525 ◽  
Author(s):  
C. M. A. LeBlanc; ◽  
J. B. Coombs ◽  
R. Davis
Keyword(s):  
Head Injury ◽  
Closed Head Injury ◽  
Closed Head

Management of Minor Closed Head Injury in Children

PEDIATRICS ◽  
2001 ◽  
Vol 107 (5) ◽  
pp. 1231-1231 ◽  
Author(s):  
A. J. Smally; ◽  
J. B. Coombs ◽  
R. Davis
Keyword(s):  
Head Injury ◽  
Closed Head Injury ◽  
Closed Head

scholarly journals Differential Leukocyte and Platelet Profiles in Distinct Models of Traumatic Brain Injury

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 500
Author(s):  
William Brad Hubbard ◽  
Meenakshi Banerjee ◽  
Hemendra Vekaria ◽  
Kanakanagavalli Shravani Prakhya ◽  
Smita Joshi ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Closed Head Injury ◽  
Diffuse Brain Injury ◽  
Blood Brain ◽  
Closed Head ◽  
Leukocyte Counts ◽  
Neutrophil Aggregation ◽  
Blood Leukocyte

Traumatic brain injury (TBI) affects over 3 million individuals every year in the U.S. There is growing appreciation that TBI can produce systemic modifications, which are in part propagated through blood–brain barrier (BBB) dysfunction and blood–brain cell interactions. As such, platelets and leukocytes contribute to mechanisms of thromboinflammation after TBI. While these mechanisms have been investigated in experimental models of contusion brain injury, less is known regarding acute alterations following mild closed head injury. To investigate the role of platelet dynamics and bioenergetics after TBI, we employed two distinct, well-established models of TBI in mice: the controlled cortical impact (CCI) model of contusion brain injury and the closed head injury (CHI) model of mild diffuse brain injury. Hematology parameters, platelet-neutrophil aggregation, and platelet respirometry were assessed acutely after injury. CCI resulted in an early drop in blood leukocyte counts, while CHI increased blood leukocyte counts early after injury. Platelet-neutrophil aggregation was altered acutely after CCI compared to sham. Furthermore, platelet bioenergetic coupling efficiency was transiently reduced at 6 h and increased at 24 h post-CCI. After CHI, oxidative phosphorylation in intact platelets was reduced at 6 h and increased at 24 h compared to sham. Taken together, these data demonstrate that brain trauma initiates alterations in platelet-leukocyte dynamics and platelet metabolism, which may be time- and injury-dependent, providing evidence that platelets carry a peripheral signature of brain injury. The unique trend of platelet bioenergetics after two distinct types of TBI suggests the potential for utilization in prognosis.

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