Circulating levels of follistatin from puberty to menopause*†*Supported by the National Institute of Child Health and Human Development Center grant HD-12303-17; the University of California, San Diego General Clinical Research Center, National Institute of Health Division of Research Resources grant M01 00827, Bethesda, Maryland; and in part by the Clayton Foundation for Research, California Division, La Jolla, California.†Presented in part at the 39th Annual Meeting of the Society for Gynecologic Investigation, San Antonio, Texas, March 18 to 21, 1992.

1996 ◽  
Vol 65 (3) ◽  
pp. 472-476 ◽  
Author(s):  
L. Michael Kettel ◽  
Louis V. DePaolo ◽  
Arlene J. Morales ◽  
Dan Apter ◽  
Nicholas Ling ◽  
...  
Keyword(s):  
Child Health ◽  
San Antonio ◽  
University Of California ◽  
Clinical Research Center ◽  
General Clinical Research Center ◽  
La Jolla ◽  
The University ◽  
Development Center ◽  
Circulating Levels ◽  
Research Resources

Heteroaromatic Construction: The Fukuyama Synthesis of Tryprostatin A

2013 ◽  
Author(s):  
Douglass F. Taber
Keyword(s):  
Organic Chemistry ◽  
University Of California ◽  
University Of Arkansas ◽  
Yale University ◽  
Au Catalyst ◽  
University Of Houston ◽  
Selective Substitution ◽  
Mcgill University ◽  
La Jolla ◽  
The University

Alessandro Palmieri of the University of Camerino developed (Synlett 2010, 2468) the condensation of a nitro acrylate 1 with a 1,3-dicarbonyl partner 2 to give the furan 3. Chaozhong Li of the Shanghai Institute of Organic Chemistry showed (Tetrahedron Lett. 2010, 51, 3678) that an alkenyl halide 4 could be cyclized to the furan 5. Ayhan S. Demir of Middle East Technical University established (Chem. Commun. 2010, 46, 8032) that a Au catalyst could catalyze the addition of an amine 7 to a cyanoester 6 to give the pyrrole 8 . Bruce A. Arndtsen of McGill University effected (Org. Lett. 2010, 12, 4916) the net three-component coupling of an imine 9, an acid chloride 10, and an alkyne 11 to deliver the pyrrole 12. Bernard Delpech of CNRS Gif-sur-Yvette prepared (Org. Lett. 2010, 12, 4760) the pyridine 15 by combining the diene 13 with the incipient carbocation 14. Max Malacria, Vincent Gandon, and Corinne Aubert of UPMC Paris optimized (Synlett 2010, 2314) the internal Co-mediated cyclization of a nitrile alkyne 5 to the tetrasubstituted pyridine 17. Yoshiaki Nakao of Kyoto University and Tamejiro Hiyama, now at Chuo University, effected (J. Am. Chem. Soc. 2010, 132, 13666) selective substitution of a preformed pyridine 18 at the C-4 position by coupling with an alkene 19. We showed (J. Org. Chem. 2010, 75, 5737) that the anion from deprotonation of a pyridine 21 could be added in a conjugate sense to 22 to give 23. Other particularly useful strategies for further substitution of preformed pyridines have been described by Olafs Daugulis of the University of Houston (Org. Lett. 2010, 12, 4277), by Phil S. Baran of Scripps/La Jolla (J. Am. Chem. Soc. 2010, 132, 13194), and by Robert G. Bergmann of the University of California, Berkeley, and Jonathan A. Ellman of Yale University (J. Org. Chem. 2010, 75, 7863). K. C. Majumdar of the University of Kalyani developed (Tetrahedron Lett. 2010, 51, 3807) the oxidative Pd-catalyzed cylization of 24 to the indole 25. Nan Zheng of the University of Arkansas showed (Org. Lett. 2010, 12, 3736) that Fe could be used to catalyze the rearrangement of the azirine 26 to the indole 27.

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