Dose finding study of the efficacy and safety of newly developed 5-ASA containing pellets in patients with active ulcerative colitis

2000 ◽  
Vol 118 (4) ◽  
pp. A780 ◽  
Author(s):  
W. Kruis ◽  
S. Bar Meir ◽  
J. Feher ◽  
M. Stolte ◽  
Evang Krankenhaus Kalk
Keyword(s):  
Ulcerative Colitis ◽  
Dose Finding ◽  
Active Ulcerative Colitis ◽  
Efficacy And Safety ◽  
Finding Study ◽  
Dose Finding Study

The optimal dose of 5-aminosalicylic acid in active ulcerative colitis: A dose-finding study with newly developed mesalamine

2003 ◽  
Vol 1 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Wolfgang Kruis ◽  
Simon Bar–Meir ◽  
Janos Feher ◽  
Oliver Mickisch ◽  
Horst Mlitz ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Optimal Dose ◽  
Dose Finding ◽  
Active Ulcerative Colitis ◽  
Aminosalicylic Acid ◽  
Finding Study ◽  
Dose Finding Study

Olsalazine in Active Ulcerative Colitis: Dose Finding Study in Japan

1988 ◽  
Vol 23 (sup148) ◽  
pp. 60-60 ◽  
Author(s):  
M. Kondo ◽  
M. Inoue ◽  
T. Shiratori ◽  
S. Tsuchiya ◽  
A. Munakata ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dose Finding ◽  
Active Ulcerative Colitis ◽  
Finding Study ◽  
Dose Finding Study

Efficacy and safety of ipragliflozin in patients with type 2 diabetes inadequately controlled on metformin: a dose-finding study

2012 ◽  
Vol 15 (5) ◽  
pp. 403-409 ◽  
Author(s):  
J. P. H. Wilding ◽  
E. Ferrannini ◽  
V. A. Fonseca ◽  
W. Wilpshaar ◽  
P. Dhanjal ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dose Finding ◽  
Efficacy And Safety ◽  
Finding Study ◽  
Dose Finding Study

Pharmacokinetics and Tolerability of a New Low Molecular Mass Heparin (RO-11) in Healthy Volunteers – A Dose-Finding Study within the Therapeutical Range

1997 ◽  
Vol 77 (01) ◽  
pp. 133-136 ◽  
Author(s):  
Liliana Falkon ◽  
Miriam M Bayés ◽  
Guillem Frontera ◽  
Mercè Garí ◽  
Manel Barbanoj ◽  
...  
Keyword(s):  
Phase I ◽  
Molecular Mass ◽  
Half Life ◽  
Dose Finding ◽  
Dose Effect ◽  
Efficacy And Safety ◽  
First Order ◽  
Finding Study ◽  
Dose Finding Study ◽  
Dose Dependent

SummaryThis paper reports on the results of a Phase I, dose-finding study with a new low molecular mass heparin (LMMH) called RO-11. The study focused on pharmacokinetics, dose-effect relationship and on tolerability of three single subcutaneous (SC) doses within the therapeutical range. After the injection of 7,500, 9,000 and 12,500 anti-FXa IU, the anti-FXa effect peaked between 3-6 h and showed a dose-dependent response. The absorption and elimination were first-order processes and the long half-life (>5 h) kept constant after increasing doses. The compound was tolerated very well and no clinically relevant prolongation of APTT, prothrombin and thrombin clotting tests was observed. At the dose of 7,500 IU, which corresponded to 110 anti-FXa IU/Kg, RO-11 exerted anti-FXa effect for at least 18-20 h. We recommend using this dose in a single SC injection, to evaluate the efficacy and safety of RO-11 in the initial treatment of DVT or PE.

Efficacy and safety of tobramycin inhalation powder in bronchiectasis patients with P. aeruginosa infection: Design of a dose-finding study (iBEST-1)

2019 ◽  
Vol 58 ◽  
pp. 101834 ◽  
Author(s):  
Michael R. Loebinger ◽  
Eva Polverino ◽  
Francesco Blasi ◽  
Stuart J. Elborn ◽  
James D. Chalmers ◽  
...  
Keyword(s):  
Dose Finding ◽  
Efficacy And Safety ◽  
Finding Study ◽  
Dose Finding Study ◽  
Inhalation Powder

Efficacy and safety of ramipril (HOE 498) in the treatment of hypertension: Dose finding study

1987 ◽  
Vol 59 (10) ◽  
pp. D121-D124 ◽  
Author(s):  
Koshiro Fukiyama ◽  
Teruo Omae ◽  
Yoshihiro Kaneko ◽  
Kaoru Yoshinaga ◽  
Osamu Iimura ◽  
...  
Keyword(s):  
Dose Finding ◽  
Efficacy And Safety ◽  
Treatment Of Hypertension ◽  
Finding Study ◽  
Dose Finding Study ◽  
Hoe 498
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