Motor and sensory function of the rectum in different types of irritable bowel syndrome

Irritable bowel syndrome (IBS) is the most common disorder diagnosed by gastroenterologists and one of the more common ones encountered in general practice. The illness has a large economic impact on health care use and indirect costs, chiefly through absenteeism. IBS is a bio-psychosocial disorder in which three major mechanisms interact: Psychosocial factors, altered motility, and/or heightened sensory function of the intestine. Treatment of patients is based on positive diagnosis of the symptom complex, limited exclusion of underlying organic disease and institution of a therapeutic trial. doi: 10.3329/taj.v18i1.3310 TAJ 2005; 18(1): 66-71

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V. Stress and irritable bowel syndrome

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.2001.280.4.g519 ◽

2001 ◽

Vol 280 (4) ◽

pp. G519-G524 ◽

Cited By ~ 260

Author(s):

Emeran A. Mayer ◽

Bruce D. Naliboff ◽

Lin Chang ◽

Santosh V. Coutinho

Keyword(s):

Irritable Bowel Syndrome ◽

Motor System ◽

Imaging Techniques ◽

Functional Brain Imaging ◽

Physiological Effects ◽

Brain Circuits ◽

Gut Function ◽

Different Types ◽

Key Features ◽

Irritable Bowel

Different types of stress play important roles in the onset and modulation of irritable bowel syndrome (IBS) symptoms. The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility and secretion and in alterations in the perception of visceral events. Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome.

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Systematic review: the role of different types of fibre in the treatment of irritable bowel syndrome

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.0269-2813.2004.01862.x ◽

2004 ◽

Vol 19 (3) ◽

pp. 245-251 ◽

Cited By ~ 198

Author(s):

C. J. Bijkerk ◽

J. W. M. Muris ◽

J. A. Knottnerus ◽

A. W. Hoes ◽

N. J. De Wit

Keyword(s):

Systematic Review ◽

Irritable Bowel Syndrome ◽

Different Types ◽

Irritable Bowel

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TREATMENT OF PATIENT WITH IRRITABLE BOWEL SYNDROME WITH DIET MODIFICATION – A CASE REPORT

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v4i9.1414 ◽

2020 ◽

Vol 4 (9) ◽

Author(s):

Malayala Tejaswini ◽

Tarun Ponugoti ◽

Anthireddy Sahithreddy

Keyword(s):

Irritable Bowel Syndrome ◽

Social Life ◽

Lifestyle Modification ◽

Therapeutic Option ◽

Developed Countries ◽

Sensory Function ◽

Older Individuals ◽

High Fiber ◽

Diet Modification ◽

Irritable Bowel

Irritable Bowel Syndrome (IBS) is characterized by chronic relapsing abdominal pain, bloating and changes in bowel habits. Despite very real symptoms, the gross and microscopy evaluation is normal in most IBS patients Due to difficulty in diagnosis, incidence is not clearly known. Prevalence in developed countries is between 5% and 10 percent. Throughout the world about 10-20 percent of adults and adolescents have symptoms consistent with IBS.IBS is a disorder that effect all ages although most patients have their first symptom before age 45.Older individuals have a lover reporting frequency. Women are diagnosed with IBS 2-3 times as often as men and makeup 80 percent of population with severe IBS. IBS is a bio-psychosocial disorder in which 3 major mechanicals interact: psychosocial factors, altered motility and heightened sensory function of intestine. Due to multifactorial etiology there is no single therapeutic option available with satisfactory efficiency. Therefore, patients with high frequency of symptoms express high levels of frustration with their frequent hospital visits, decreased work & social life and food sensitivity. If treatment is carried out to improve symptoms, some people can control their symptoms by managing diet, lifestyle and stress. Others need medication and counselling. In our case the patient wasn’t satisfied with the pharmacotherapy alone. He used diet modification and lifestyle modification as a main treatment strategy. Satisfactory results were observed with such changes. Keywords: IBS, psychosocial, bio-psychosocial, lifestyle modification, diet modification, low FODMAP diet, high fiber diet, yoga, stress

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Are Functional Constipation and Constipation-Subtype Irritable Bowel Syndrome Distinct With Respect To 5-Hydroxytryptamine Signalling and Motor-Sensory Function?

Gastroenterology ◽

10.1016/s0016-5085(11)62185-9 ◽

2011 ◽

Vol 140 (5) ◽

pp. S-527

Author(s):

Chander Shekhar ◽

Phillip J. Monaghan ◽

Jo Adaway ◽

Julie Morris ◽

Peter J. Whorwell ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Functional Constipation ◽

Sensory Function ◽

Irritable Bowel

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Dimensions of Gut Dysfunction in Irritable Bowel Syndrome: Altered Sensory Function

Canadian Journal of Gastroenterology ◽

10.1155/1999/963469 ◽

1999 ◽

Vol 13 (suppl a) ◽

pp. 12A-14A ◽

Cited By ~ 9

Author(s):

Fernando Azpiroz

Keyword(s):

Irritable Bowel Syndrome ◽

Clinical Symptoms ◽

Afferent Input ◽

Sensory Function ◽

Visceral Hyperalgesia ◽

Gut Dysfunction ◽

Irritable Bowel ◽

Clinical Conditions ◽

Normal Perception ◽

Stimulation Of

Growing evidence suggests that symptoms in patients with irritable bowel syndrome (IBS) may be due to a visceral sensory dysfunction. Specifically, it has been shown that patients with IBS have hypersensitive responses to distension of the rectum, whereas their tolerance to somatic stimuli is normal or even increased. Furthermore, patients with IBS have hypersensitivity of the small bowel, which selectively affects mechanosensitive afferents, with normal perception of electrical stimulation of the gut. Sensory dysfunctions may also be associated with altered reflex activity, which may contribute to the clinical symptoms. Normally, a series of mechanisms at different strata of the nervous system modulate visceral afferent input and determine conscious perception. Conceivably, a dysfunction of these regulatory mechanisms may alter sensitivity in clinical conditions. To date, neither the origin nor the clinical significance of visceral hyperalgesia has been elucidated. However, it seems likely that the sensory and reflex dysfunctions of the gut in IBS may combine to different degrees, and their interaction may explain the clinical pleomorphism of the syndrome.

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