Are Functional Constipation and Constipation-Subtype Irritable Bowel Syndrome Distinct With Respect To 5-Hydroxytryptamine Signalling and Motor-Sensory Function?

2011 ◽  
Vol 140 (5) ◽  
pp. S-527
Author(s):  
Chander Shekhar ◽  
Phillip J. Monaghan ◽  
Jo Adaway ◽  
Julie Morris ◽  
Peter J. Whorwell ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Constipation ◽  
Sensory Function ◽  
Irritable Bowel

scholarly journals Are functional constipation and constipation-subtype irritable bowel syndrome distinct with respect to 5-hydroxytryptamine signalling and motor-sensory function?

Gut ◽  
2011 ◽  
Vol 60 (Suppl 1) ◽  
pp. A163-A164
Author(s):  
C. Shekhar ◽  
P. Monaghan ◽  
J. Adaway ◽  
J. Morris ◽  
P. Whorwell ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Constipation ◽  
Sensory Function ◽  
Irritable Bowel

Motor and sensory function of the rectum in different types of irritable bowel syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A399-A399
Author(s):  
J STEENS ◽  
P SCHAAR ◽  
C LAMERS ◽  
A MASCLEE
Keyword(s):  
Irritable Bowel Syndrome ◽  
Sensory Function ◽  
Different Types ◽  
Irritable Bowel

T1414 Effects of Mosapride Citrate, a 5-HT4 Receptor Agonist, On Rectosigmoid Motor and Sensory Function in Patients with Irritable Bowel Syndrome

2008 ◽  
Vol 134 (4) ◽  
pp. A-550-A-551
Author(s):  
Motoyori Kanazawa ◽  
Satoshi Watanabe ◽  
Chie Tana ◽  
Shin Fukudo
Keyword(s):  
Irritable Bowel Syndrome ◽  
Receptor Agonist ◽  
Sensory Function ◽  
Mosapride Citrate ◽  
Irritable Bowel

scholarly journals Significance of Rome II-defined functional constipation in Taiwan and comparison with constipation-predominant irritable bowel syndrome

2006 ◽  
Vol 24 (2) ◽  
pp. 429-438 ◽  
Author(s):  
C.-L. LU ◽  
F.-Y. CHANG ◽  
C.-Y. CHEN ◽  
J.-C. LUO ◽  
S.-D. LEE
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Constipation ◽  
Irritable Bowel

scholarly journals Serotonin Level and Lipid Metabolism Indices in Patients with Irritable Bowel Syndrome with Constipation Against the Background of Various Degrees of Obesity

2018 ◽  
Vol 25 (2) ◽  
Author(s):  
Vasyl Mishchuk ◽  
Galina Grygoruk
Keyword(s):  
Body Mass Index ◽  
Irritable Bowel Syndrome ◽  
Lipid Profile ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Functional Constipation ◽  
The Body ◽  
Normal Body Mass Index ◽  
Serotonin Level ◽  
Irritable Bowel

Recent research shows that the number of diseases associated with obesity has been increasing. In obese persons, association with functional constipation is noted in 24.0% of cases, and obesity is recorded in 60.0% of patients with functional constipation. Among the possible mechanisms for the development of such a combination are changes in serotonin level in the blood, although the existing data are ambiguous and sometimes controversial.The objective of the study is to investigate the changes in serotonin level in the blood of obese patients in combination with constipation and its relationship with the lipid profile of the blood.Materials and methods. 63 patients with obesity in combination with irritable bowel syndrome with constipation (IBSc), 24 patients with normal body mass index and 10 practically healthy people were examined. 25 patients with obesity and constipation had a body mass index of 32.8±0.24kg/m2, 28 patients – 37.8±kg/m2, and 10 patients – 42.6±0.5kg/m2. In patients with irritable bowel syndrome without obesity, the body mass index was 21.7±0.4kg/m2. The blood serotonin level and lipid profile of the blood was determined in all patients.Results. It was deermined that in case of irritable bowel syndrome with constipation, serotonin level in the blood was reduced. In obesity with IBSc, the concentration of serotonin, on the contrary, was elevated. All patients with IBSc and obesity were marked an elevated level of total cholesterol and triglycerides. A direct correlation between high levels of triglycerides and serotonin concentration in serum of such comorbid patients was detected. The increase in the degree of obesity in the presence of IBSc was accompanied by a decrease in the concentration of cholesterol of high density lipoprotein. Patients with IBSc without excessive body weight had no such deviations.Conclusions. With an increase in the degree of obesity, serotonin level in the blood increases and the lipid blood spectrum worsens.

Tu2064 ROME III Functional Constipation (FC) and Irritable Bowel Syndrome - Constipation Predominant (IBS-C) - Truly Distinct Disorders or One Disease Spectrum?

2013 ◽  
Vol 144 (5) ◽  
pp. S-917-S-918 ◽  
Author(s):  
Natasha A. Koloski ◽  
Michael P. Jones ◽  
Melissa Young ◽  
Nicholas J. Talley
Keyword(s):  
Irritable Bowel Syndrome ◽  
Functional Constipation ◽  
Disease Spectrum ◽  
Rome Iii ◽  
Irritable Bowel
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