M1058 Helicobacter pylori Recurrence in Developed and Developing Countries: Meta-Analysis of 13c-Urea Breath Test Follow-Up After Eradication

2008 ◽  
Vol 134 (4) ◽  
pp. A-329
Author(s):  
Yaron Niv ◽  
Rachel Hazazi
2001 ◽  
Vol 120 (5) ◽  
pp. A579 ◽  
Author(s):  
Atsushi Sawada ◽  
Hitoshi Tajiri ◽  
Norikazu Yoshimura ◽  
Kosuke Kozaiwa ◽  
Shinobu Ida ◽  
...  

Helicobacter ◽  
2011 ◽  
Vol 16 (4) ◽  
pp. 327-337 ◽  
Author(s):  
Yelda A. Leal ◽  
Laura L. Flores ◽  
Ezequiel M. Fuentes-Pananá ◽  
Roberto Cedillo-Rivera ◽  
Javier Torres

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Doron Boltin ◽  
Zohar Levi ◽  
Tsachi Tsadok Perets ◽  
Hemda Schmilovitz-Weiss ◽  
Rachel Gingold-Belfer ◽  
...  

Background. There are continual efforts to identify factors which influence the success of first-line therapy for Helicobacter pylori (H. pylori) infection. The 13C-urea breath test result (C13-UBT) utilizes H. pylori urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Methods. Adult patients who underwent a first-time 13C-urea breath test between January 2010 and January 2016 were included. In order to isolate a naïve test-and-treat population who were unlikely to have undergone an initial endoscopy-based H. pylori test, we excluded patients > 45 years and those with a previous C13-UBT. Data were extracted from the Clalit Health Services laboratory database. Results. A total of 94,590 subjects (36.1% male, age 28.5 ± 6.0 years) who underwent a first-time C13-UBT during the study period were included. C13-UBT was positive in 48,509 (51.3%) subjects. A confirmatory posttreatment C13-UBT was performed in 18,375 (37.8%), and eradication was successful in 12,018 (65.4%). The mean C13-UBT recording was 20.6 ± 16.2 DOB in subjects with successful eradication and 19.5 ± 13.1 DOB in subjects with treatment failure (OR, 1.01; 95% CI 1.00-1.01, p<0.01). Among patients in the upper quintile of C13-UBT measurement, eradication was achieved in 67.6%, compared to 62.6% in the lower quintile (OR, 1.22; 95% CI 1.11-1.35, p<0.01). Subjects in the top 1 percentile (C13-UBT ≥ 70 DOB) achieved eradication in 75.0%, compared to 65.3% among subjects with C13-UBT < 70 DOB (OR, 1.59; 95% CI 1.05-2.41, p<0.01). Conclusions. The superiority in H. pylori eradication observed in subjects with a higher C13-UBT DOB is small but significant. Further studies should examine the physiological and microbiological basis for this finding.


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