Revisit of Field Cancerization in Squamous Cell Carcinoma of Upper Aerodigestive Tract: Better Risk Prediction With Epigenetic Markers

Ten patients over sixty years of age with no history of tobacco or alcohol use were treated for squamous cell carcinoma of the upper aerodigestive tract between 1979 and 1991. Nine of these ten patients were women with lesions confined to the oral cavity and oropharynx. Modes of treatment included surgery, radiation, or a combination of surgery and radiation. Followup from 1 to 10 years revealed two deaths from local and distant spread, and eight patients with no evidence of disease. Recurrences after treatment were aggressive and occurred within the same region as the primary lesion. Although most patients with upper aerodigestive squamous cell carcinoma are men with alcohol and/or tobacco exposure, this study demonstrates findings consistent with field cancerization in a group of older women with no risk factors.

Download Full-text

ELECTIVE IRRADIATION OF THE N0 NECK IN SQUAMOUS CELL CARCINOMA OF THE UPPER AERODIGESTIVE TRACT

Otolaryngologic Clinics of North America ◽

10.1016/s0030-6665(05)70088-8 ◽

1998 ◽

Vol 31 (5) ◽

pp. 803-813 ◽

Cited By ~ 17

Author(s):

Daniel Shasha ◽

Louis B. Harrison

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Aerodigestive Tract ◽

Upper Aerodigestive Tract ◽

N0 Neck

Download Full-text

Posterior triangle metastases of squamous cell carcinoma of the upper aerodigestive tract

The American Journal of Surgery ◽

10.1016/s0002-9610(05)80340-x ◽

1993 ◽

Vol 166 (4) ◽

pp. 395-398 ◽

Cited By ~ 91

Author(s):

Bruce J. Davidson ◽

Vijay Kulkarny ◽

Mark D. Delacure ◽

Jatin P. Shah

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Aerodigestive Tract ◽

Upper Aerodigestive Tract ◽

Posterior Triangle

Download Full-text

Is there a role for flexible oesophagogastroscopy in upper aerodigestive tract squamous cell carcinoma?

The Journal of Laryngology & Otology ◽

10.1017/s0022215109991988 ◽

2009 ◽

Vol 124 (4) ◽

pp. 417-419 ◽

Cited By ~ 1

Author(s):

T J Beech ◽

M I Trotter ◽

A L McDermott ◽

W Mandal ◽

A J Batch

Keyword(s):

Squamous Cell Carcinoma ◽

Head And Neck Cancer ◽

Cell Carcinoma ◽

Head And Neck ◽

Patient Group ◽

Squamous Cell ◽

Aerodigestive Tract ◽

Upper Aerodigestive Tract ◽

Diagnostic Investigation

AbstractIntroduction:There is growing evidence to suggest that reflux (both laryngopharyngeal and gastroesophageal) has a role in the development of upper aerodigestive tract squamous cell carcinoma. This study discusses the role of identifying reflux in this patient group, and its prevalence.Methods:Prospective review of patients with head and neck cancer undergoing flexible oesophagogastroscopy as part of their diagnostic investigation.Results:Forty-five consecutive patients were identified. All patients were found to have evidence of oesophagitis, with 28 having oesophageal erosions and two Barrett's oesophagitis.Conclusion:Flexible oesophagogastroscopy is a useful test in patients with upper aerodigestive tract squamous cell carcinoma.

Download Full-text