Mo2071 A Placebo Controlled Randomised Treatment Trial for Functional Dyspepsia Including Post-Treatment Drug Withdraw and Placebo Withdraw Effects

2013 ◽  
Vol 144 (5) ◽  
pp. S-733 ◽  
Author(s):  
Gerald Holtmann ◽  
Jane M. Andrews ◽  
Richard H. Holloway ◽  
Justin Beilby ◽  
Birgit Adam ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Post Treatment ◽  
Treatment Trial

scholarly journals 1017 The Functional Dyspepsia Treatment Trial (FDTT): 5-HTT LPR and Gn β3 825C>T Are Not Pharmacogenetic Markers for FD Antidepressant Treatment Response

2014 ◽  
Vol 146 (5) ◽  
pp. S-179
Author(s):  
Yuri A. Saito ◽  
Ann E. Almazar ◽  
Giles R. Locke ◽  
Ernest P. Bouras ◽  
Colin W. Howden ◽  
...  
Keyword(s):  
Treatment Response ◽  
Functional Dyspepsia ◽  
Antidepressant Treatment ◽  
Treatment Trial

Quantitative bone scan lesion area as an early surrogate outcome measure indicative of overall survival in metastatic castration-resistant prostate cancer.

2015 ◽  
Vol 33 (7_suppl) ◽  
pp. 179-179
Author(s):  
Matthew S. Brown ◽  
Hyun J. Kim ◽  
Gregory H. Chu ◽  
Martin Allen-Auerbach ◽  
Cheryce Fischer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Overall Survival ◽  
Bone Scan ◽  
Post Treatment ◽  
Whole Body ◽  
Treatment Trial ◽  
Castration Resistant Prostate Cancer ◽  
Lesion Area ◽  
Surrogate Outcome ◽  
Castration Resistant

179 Background: Bone Scan Lesion Area (BSLA) is a biomarker that can be computed semi-automatically from whole-body scintigraphic imaging as a measure of overall bone tumor burden. Initial development and validation, including correlation with outcomes, was performed in trial cohorts from a single drug treatment with controls in subjects with metastatic castrate-resistant prostate cancer (CRPC). A 30% increase/decrease in BSLA was defined as progression/response on bone scan. We hypothesize that, when applied to an independent treatment trial cohort with a different mechanism of drug action, baseline BSLA and Week 12 change post-treatment are predictive of a subject's overall survival. Methods: From an anonymized imaging research database a cohort of 198 CRPC subjects was identified who enrolled in a treatment trial (127 treated, 71 placebo). This cohort was independent of those used for biomarker development and initial validation, and involved a different mechanism of drug action. Subjects underwent standard of care whole-body bone scintigraphy with 99mTc-Methyl diphosphonate (99mTc-MDP). BSLA was calculated at baseline and response at Week 12. Multivariate Cox regression was used to test whether (1) baseline BSLA, and (2) early changes in BSLA (12 weeks post treatment) were predictive of overall survival. Results: BSLA < 2000 mm2 at baseline was a prognostic factor (HR=0.6; p=0.003) and predictive of longer survival (HR=0.4; p<0.001). Subjects without PD by BSLA at Week 12 had significantly longer survival than subjects with PD: median 170 days vs. 186 days in the placebo group and 260 days vs. 392 days in the treatment group. The overall survival rates between non-PD and PD subjects were statistically different (HR=0.64, p=0.007). Conclusions: BSLA is calculated semi-automatically from bone scans and provides a quantitative and objective treatment response assessment. Baseline BSLA and early changes post treatment were found to be predictive of overall survival in patients with metastatic castration-resistant prostate cancer. BSLA has now been demonstrated to be an early surrogate outcome for overall survival in different drug treatments.

Tu1435 Functional Dyspepsia Treatment Trial (FDTT): Association of Adequate Relief Response and Psychological Measures

2015 ◽  
Vol 148 (4) ◽  
pp. S-890-S-891
Author(s):  
Linda M. Herrick ◽  
Yuri A. Saito ◽  
Ann E. Almazar ◽  
Giles Locke ◽  
Ernest P. Bouras ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Treatment Trial ◽  
Psychological Measures

Tu1430 Functional Dyspepsia Treatment Trial (FDTT): Effect of Antidepressants on Mood Response in Functional Dyspepsia

2015 ◽  
Vol 148 (4) ◽  
pp. S-889
Author(s):  
Ann E. Almazar ◽  
Yuri A. Saito ◽  
Linda M. Herrick ◽  
Giles Locke ◽  
Ernest P. Bouras ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Treatment Trial

scholarly journals 810 The Functional Dyspepsia Treatment Trial (Fdtt) Key Results

2013 ◽  
Vol 144 (5) ◽  
pp. S-140 ◽  
Author(s):  
Giles R. Locke ◽  
Ernest P. Bouras ◽  
Colin W. Howden ◽  
Darren M. Brenner ◽  
Brian E. Lacy ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Treatment Trial

Polymorphisms of 5-HTT LPR and GNβ3 825C>T and Response to Antidepressant Treatment in Functional Dyspepsia: A Study from The Functional Dyspepsia Treatment Trial

2017 ◽  
Vol 112 (6) ◽  
pp. 903-909 ◽  
Author(s):  
Yuri A Saito ◽  
Richard G Locke ◽  
Ann E Almazar ◽  
Ernest P Bouras ◽  
Colin W Howden ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Antidepressant Treatment ◽  
Treatment Trial

Ultrastructure of bronchopulmonary lavage cells from bovines administered 3-methylindole: II. 24 hours post-treatment

1984 ◽  
Vol 42 ◽  
pp. 202-203
Author(s):  
Amreek Singh ◽  
Judith M. McLaren ◽  
Onkar S. Atwal ◽  
Peter Eyre
Keyword(s):  
Plasma Cells ◽  
Ciliated Cell ◽  
Lavage Fluid ◽  
Treated Group ◽  
Post Treatment ◽  
Lung Edema ◽  
Ciliated Cells ◽  
Thin Sections ◽  
Variable Diameter ◽  
Cell Pellet

Introduction3-methylindole (MI), a rumen metabolite of the amino acid L-tryptophan, has been shown to produce bovine pulmonary edema and emphysema. The airways contain free and exfoliated cells. A morphologic analysis of these cells may complement the understanding of the mechanism of lung edema. Ultrastructure of the bronchopulmonary lavage (BL) cells 24 h following MI oral administration to calves is described in this experiment. The 12 hours post-treatment results were described earlier.Materials and MethodsTwo Holstein-Friesian calves were each administered an oral dose of 0.2 g MI/Kg body weight and another two calves served as controls. The animals were euthanized with sodium pentabarbitol 24 h after receiving the compound. The lungs and trachea were removed and 0.1 M sodium phosphate buffered saline was infused into the lungs through the trachea. Glutaraldehyde fixative was added to the recovered BL fluid so as to form a 1% solution. The fluid was centrifuged and the resulting cell pellet was suspended in the buffer. The procedures were repeated on the suspension; the pellet was post-fixed in osmium tetroxide and was processed by conventional methods of section preparations for TEM examination. Lung samples from caudal lobes were fixed in 1.5% glutaraldehyde to obtain tissue sections for TEM.Results and DiscussionPulmonary alveolar macrophages (AM), neutrophils, ciliated epithelial cells, globule leukocytes and plasma cells were recovered from the BL fluid of the control and Mi-administered calves. Ciliated cells and globule leukocytes could not be harvested from the controls. The AM obtained from the treated calves (Fig. 1) in comparison with similar cells from the controls were larger, and contained large membrane-limited inclusions (phagolysosomes). There was a remarkable similarity between the lavaged AM and the AM studied in thin sections of lung (cf. Fig. 1 and Fig. 2). The neutrophil was the second most abundant cell type retrieved from the lavage fluid from the calves of control or treated group. Except for scanty pseudopodia in the neutrophils obtained from the Mi-receiving calves, the cells appeared unaltered (Fig. 3). Ciliated cells were abundant in the BL fluid of Mi-ingesting calves. A heterogeneous collection of vesicles filled the ciliated cell cytoplasm (Fig. 3). Globule leukocytes were commonly observed among BL cells of treated calves. The globule leukocytes were ca. 15 μm in diameter and contained round or elliptical nuclei with conspicuous nucleoli. The cytoplasmic granules, which are a prominent feature of globule leukocytes, were electron-opaque and had a variable diameter (0.5-3.0 μm). A one-line account of globule leukocytes in the bronchi of steers administered MI has appeared. Plasma cells were rare. Ultrastructure of BL cells is compatible with their response to chemical insult by MI.

Continuous Positive Airway Pressure (CPAP) Therapy for the Treatment of Hypernasality: A Single Case Study

2014 ◽  
Vol 24 (2) ◽  
pp. 48-58 ◽  
Author(s):  
Lakshmi Kollara ◽  
Graham Schenck ◽  
Jamie Perry
Keyword(s):  
Continuous Positive Airway Pressure ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
Single Case ◽  
Treatment Method ◽  
Post Treatment ◽  
Subjective Perception ◽  
Cpap Therapy ◽  
Long Term Follow Up

Studies have investigated the applications of Continuous Positive Airway Pressure (CPAP) therapy in the treatment of hypernasality due to velopharyngeal dysfunction (VPD; Cahill et al., 2004; Kuehn, 1991; Kuehn, Moon, & Folkins, 1993; Kuehn et al., 2002). The purpose of this study was to examine the effectiveness of CPAP therapy to reduce hypernasality in a female subject, post-traumatic brain injury (TBI) and pharyngeal flap, who presented with signs of VPD including persistent hypernasality. Improvements in mean velopharyngeal orifice size, subjective perception of hypernasality, and overall intelligibility were observed from the baseline to 8-week post-treatment assessment intervals. Additional long-term assessments completed at 2, 3, and 4 months post-treatment indicated decreases in immediate post-treatment improvements. Results from the present study suggest that CPAP is a safe, non-invasive, and relatively conservative treatment method for reduction of hypernasality in selected patients with TBI. More stringent long-term follow up may indicate the need for repeated CPAP treatment to maintain results.

Evidence-based subtypes in functional dyspepsia with confirmatory factor analysis: Psychosocial and physiopathological correlates

2001 ◽  
Vol 120 (5) ◽  
pp. A51-A52 ◽  
Author(s):  
B FISCHLER ◽  
J VANDENBERGHE ◽  
P PERSOONS ◽  
V GUCHT ◽  
D BROEKAERT ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Confirmatory Factor Analysis ◽  
Functional Dyspepsia ◽  
Evidence Based ◽  
Confirmatory Factor
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