Tu1051 Mapping Chronic Liver Disease Questionnaire (CLDQ) Scores Onto SF-6D Utility Values in Patients With Primary Sclerosing Cholangitis: Results From a Population-Based Cohort Study

2014 ◽  
Vol 146 (5) ◽  
pp. S-738 ◽  
Author(s):  
Evangelos Kalaitzakis ◽  
Maria Benito De Valle ◽  
Monira Rahman ◽  
Björn Lindkvist ◽  
Einar S. Bjornsson ◽  
...  
2015 ◽  
Vol 25 (4) ◽  
pp. 947-957 ◽  
Author(s):  
Evangelos Kalaitzakis ◽  
Maria Benito de Valle ◽  
Monira Rahman ◽  
Björn Lindkvist ◽  
Einar Björnsson ◽  
...  

2020 ◽  
Vol 23 (11) ◽  
pp. 732-739
Author(s):  
Mohssen Nassiri Toosi ◽  
Bobak Moazzami ◽  
Ali Jafarian ◽  
Amirhossein Emami ◽  
Farid Azmodeh Ardalan ◽  
...  

Background:Thrombocytopenia is the most well-known hematological abnormality occurring in patients with liver cirrhosis. However, the rate of platelet count reduction is not the same across different chronic liver disease etiologies. Therefore, the aim of the present study was to compare the differences in the platelet count levels between primary sclerosing cholangitis-related cirrhosis (PSC-C) and other causes of liver disease. Methods:In this cohort study, the association between PSC-C and risk of platelet count reduction was investigated. The platelet counts were repeatedly measured among 242 consecutive cirrhotic patients (144 males and 98 females) including 67 patients with PSC-C and 175 patients with non-PSC-C who were on the waiting list for liver transplantation. The Poisson regression analysis was used to assess the relationship between platelet count reduction and PSC-C, after adjusting for potential confounding factors. Results: During the five years of follow-up, comparison between the two groups revealed that significantly higher levels of platelet were found in PSC-C patients when compared to the non-PSC-C group [148 (106–280) (×103 /µL) vs. 79 (50–110) (×103 /µL), respectively, P < 0.001]. After adjusting for confounding factors, a significant association was observed between non-PSC-C and the risk of platelet count reduction (relative risk, RR: 14.81, 95% CI: 1.21–160.42; P= 0.03). Conclusion: The findings indicate that PSC-C patients present with mild degrees of thrombocytopenia compared to other causes of chronic liver disease.


2012 ◽  
Vol 22 (1) ◽  
pp. 167-172 ◽  
Author(s):  
Samantha Mucci ◽  
Vanessa de Albuquerque Citero ◽  
Adriano Miziara Gonzalez ◽  
Luciana Geocze ◽  
Stephan Geocze ◽  
...  

Author(s):  
José Ivo Filho ◽  
Michelle Duarte Nascimento ◽  
Bruna Angélica Reche ◽  
Juliana Rodrigues Correia ◽  
Odete Mauad Cavenaghi

O objetivo do presente estudo foi avaliar o impacto de um programa de reabilitação física sobre a qualidade de vida de uma paciente candidata ao transplante de fígado. Trata-se de uma paciente do sexo feminino, 43 anos, diagnóstico médico de cirrose biliar primária, fibrose porta-porta, há seis anos, Child B e MELD 17, antecedente de hipertensão arterial sistólica, diabetes mellitus e dislipidemia. Foi avaliada antes e após aplicação do protocolo de reabilitação em cinco sessões consecutivas, por meio do questionário Chronic Liver Disease Questionnaire (CLDQ). Observou-se uma resposta positiva na melhoria da qualidade de vida da paciente quando submetida ao programa de reabilitação física, porém, de forma discreta, devido à percepção de limitações funcionais pertinentes à doença, demonstrando alteração emocional. Este estudo permitiu uma abordagem criteriosa da candidata quanto às suas limitações pessoais e características da doença para servirem como parâmetro a um programa de tratamento fisioterapêutico, baseado na reabilitação e melhora da qualidade de vida. Novos estudos poderão ser desenvolvidos sobre o tema abordado, o que contribuirá de forma direta na ampliação do conhecimento, enriquecimento e atualização da literatura científica.


2018 ◽  
Vol 28 (1) ◽  
pp. 48-54
Author(s):  
Hiang Keat Tan ◽  
Yean Lee ◽  
Pei Yuh Chia ◽  
Shaik Hussain Nurshifa ◽  
Travis Kim Chye Tan ◽  
...  

Background: Patients with chronic liver disease often suffer from poor quality of life. The Chronic Liver Disease Questionnaire (CLDQ) is a validated tool to assess health-related quality of life in these patients. It has been translated and validated for use in many countries and languages globally. Objectives: We aimed to translate Mainland Chinese Mandarin to Singapore Mandarin and perform cross-cultural adaption of CLDQ for the Mandarin-speaking population in Singapore (CLDQ-SG). Methods: This study was conducted based on the International Society for Pharmacoeconomics and Outcomes Research Principles of Good Practice. The study consisted of two parts: part one involved cognitive debriefing and cultural adaption of CLDQ, and part two was a pilot study on the first version of CLDQ-SG among adult patients with chronic liver disease in a tertiary hospital. Results: During the cognitive debriefing process of part one, questions beginning with “recent” (最近) two weeks in Mandarin were changed to “last” (在过去) two weeks. Eighteen patients were recruited for part two of the study (50% male, mean age 49±13 years). Time taken to complete CLDQ-SG was 15±8 minutes, and the mean score was 5.1±0.5. The reliability of measurements for all domains was good, with an intra-class correlation coefficient ≥0.8. Items one and four needed further restructuring. There were no discrepancies between CLDQ and CLDQ-SG. Conclusion: This study showed that CLDQ-SG was culturally acceptable by the Mandarin-speaking population in Singapore. There were only two items that needed revision in the finalized CLDQ-SG.


2017 ◽  
Vol 7 ◽  
pp. S47
Author(s):  
Amit Goel ◽  
Karunanithi Arivazhagan ◽  
Avani Sasi ◽  
Vanathy Shanmugam ◽  
Seleena Koshi ◽  
...  

2014 ◽  
Vol 55 (2) ◽  
pp. 163-171 ◽  
Author(s):  
Jer-Hwa Hsu ◽  
I-Chia Chien ◽  
Ching-Heng Lin ◽  
Yiing-Jenq Chou ◽  
Pesus Chou

Sign in / Sign up

Export Citation Format

Share Document