Tu1208 Prevalence of Antral Gastritis in the General Population in Subjects With Rome III Functional Dyspepsia, Epigastric Pain Syndrome (EPS) and Post Prandial Distress Syndrome (PDS)

ABSTRACT BACKGROUND Medical literature has shown dyspepsia and heartburn-related symptoms occur among 15% to 40% of the population. These symptoms can occur at any age and are more prevalent in women. OBJECTIVE Investigate the prevalence of dyspeptic symptoms and heartburn among individuals over 18. METHODS Individuals over 18 were randomly selected in public venues in Belo Horizonte/MG to participate. A standardized questionnaire that included questions related to social-demographic characteristics, eating habits, digestive symptoms, medical appointments, medications, exams, previous surgeries and comorbidities was applied. A questionnaire about functional dyspepsia diagnosis (Rome III) was also applied. RESULTS A total of 548 individuals were interviewed. Among these, 58.4% were women, 59.3% were white, 55.9% were single and the average age was 36 years. Within this group, 376 individuals (68.6%) declared to have some symptom and/or use medication to relieve dyspepsia symptoms, and for these patients were applied the Rome III questionnaire. Based on the diagnostic criteria for the questionnaire proposed by the Rome III consensus, the symptom of postprandial fullness was reported by 6.7% of the individuals, early satiety (3.5%) and epigastric pain (10.6%). The overlap of these symptoms was very frequent. The prevalence of functional dyspepsia was 10.6% (postprandial discomfort syndrome (8.2%) and epigastric pain syndrome (2.4%). Among all participants, 52.5% reported heartburn, and 11.1% presented this symptom at least once a week. The most used drug was omeprazole. CONCLUSION The prevalence of dyspeptic symptoms and heartburn among a Brazilian adult urban population is similar to those described in other countries.

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Su2074 Gastrointestinal (GI) Symptoms Induced by Spicy, Sour, and Fatty Food Ingestion in Functional Dyspepsia (FD): A Difference Between Epigastric Pain Syndrome (EPS) and Postprandial Distress Syndrome (PDS)

Gastroenterology ◽

10.1016/s0016-5085(13)62036-3 ◽

2013 ◽

Vol 144 (5) ◽

pp. S-549-S-550 ◽

Cited By ~ 1

Author(s):

Tanisa Patcharatrakul ◽

Prima Singhagowinta ◽

Pinit Kullavanijaya ◽

Sutep Gonlachanvit

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Food Ingestion ◽

Postprandial Distress Syndrome ◽

Gi Symptoms ◽

Epigastric Pain Syndrome ◽

Fatty Food

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Evaluation of main functional dyspepsia symptoms after probiotic administration in patients receiving conventional pharmacological therapies

Journal of International Medical Research ◽

10.1177/0300060520982657 ◽

2021 ◽

Vol 49 (1) ◽

pp. 030006052098265

Author(s):

Lorenzo Drago ◽

Gabriele Meroni ◽

Dario Pistone ◽

Luigi Pasquale ◽

Giuseppe Milazzo ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Current Data ◽

Lactobacillus Delbrueckii ◽

End Of Treatment ◽

Epigastric Pain Syndrome ◽

Dyspeptic Symptoms ◽

Lactobacillus Delbrueckii Subsp

Objective Postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) are the two main forms of functional dyspepsia (FD). Probiotics are a promising therapy for FD, but current data remains heterogeneous. This work aims to evaluate a probiotic combination of Lacticaseibacillus rhamnosus LR04 (DSM 16605), Lactiplantibacillus pentosus LPS01 (DSM 21980), Lactiplantibacillus plantarum LP01 (LMG P-21021), and Lactobacillus delbrueckii subsp. delbruekii LDD01 (DMS 22106), alone or together with other pharmacological therapies, for clinical improvement of symptoms associated with FD. Methods Patients with FD were enrolled and divided into two groups: PDS and EPS. Probiotic alone or combined with prokinetics, antacids, or proton-pump-inhibitors were administered for 30 days. A progressive-score scale was used to evaluate symptoms in all patients at the beginning of the trial and at 15 days after the end of treatment. Results A cohort of 2676 patients were enrolled (1 357 with PDS; 1 319 with EPS). All patients showed significant improvements in dyspeptic symptoms following treatment. In patients with PDS, probiotic alone resulted in the lowest prevalence of symptoms following treatment, while patients with EPS showed no clear between-treatment differences. Conclusions Dyspeptic symptoms were reduced following treatment in all patients.

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Functional Dyspepsia: Subtypes, Risk Factors, and Overlap with Irritable Bowel Syndrome in a Population of African Patients

Gastroenterology Research and Practice ◽

10.1155/2012/562393 ◽

2012 ◽

Vol 2012 ◽

pp. 1-5 ◽

Cited By ~ 12

Author(s):

Sylvester Chuks Nwokediuko ◽

Uchenna Ijoma ◽

Olive Obienu

Keyword(s):

Risk Factors ◽

Irritable Bowel Syndrome ◽

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome ◽

Irritable Bowel ◽

African Patients

Background. Functional dyspepsia is the prototype functional gastrointestinal disorder. This study was designed to determine its prevalence, subtypes, and risk factors associated with the subtypes.Method. Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria.Results. Of 192 patients who had functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes accounted for 79.2%, 62.5%, and 50%, respectively. Multivariate analysis of the risk factors showed that independent predictors of postprandial distress syndrome were alcohol and irritable bowel syndrome while irritable bowel syndrome was independent predictor of epigastric pain syndrome. Alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs were independent predictors of cooccurrence of postprandial distress syndrome and epigastric pain syndrome.Conclusion. Functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients. Regarding symptomatology, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes account for 79.2%, 62.5%, and 50%, respectively. Risk factors for functional dyspepsia are irritable bowel syndrome, alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs.

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903 Impaired Accommodation Is a Feature of Functional Dyspepsia Patients with Postprandial Distress Syndrome, Not with Epigastric Pain Syndrome

Gastroenterology ◽

10.1016/s0016-5085(09)60632-6 ◽

2009 ◽

Vol 136 (5) ◽

pp. A-140-A-141 ◽

Cited By ~ 1

Author(s):

Sebastien Kindt ◽

Raf Bisschops ◽

Rita Vos ◽

Lieselot Holvoet ◽

Philip Caenepeel ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome

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Prevalence and pathophysiology of post-prandial migraine in patients with functional dyspepsia

Cephalalgia ◽

10.1177/0333102419857596 ◽

2019 ◽

Vol 39 (12) ◽

pp. 1560-1568

Author(s):

Michele Di Stefano ◽

Ennio Pucci ◽

Emanuela Miceli ◽

Elisabetta Pagani ◽

Natascia Brondino ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Gastric Accommodation ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome ◽

Gastric Emptying Time ◽

Early Satiation ◽

Severe Migraine

Background Migraine is a condition frequently associated with gastrointestinal disorders. Previous reports have shown the relationship between irritable bowel syndrome and migraine, but no data are yet available in patients with functional dyspepsia. We therefore evaluated whether alteration of gastric sensorimotor activity may be related to migraine. Methods Sixty patients affected by functional dyspepsia, 38 with postprandial distress syndrome and 22 with epigastric pain syndrome were enrolled in a cohort study. Presence and severity of dyspeptic symptoms, migraine presence and severity, gastric sensitivity thresholds during fasting and postprandial period, gastric accommodation and gastric emptying time were evaluated. Results In epigastric pain syndrome, 12/22 (54%) patients suffered from migraine and this condition was never correlated with meal ingestion. In postprandial distress syndrome patients, 29/38 (76%) suffered from migraine, in 26/29 (89%) its onset was considered as meal-related, and migraine severity was significantly correlated with postprandial modification of the gastric discomfort threshold (r = −0.73; p < 0.001). In patients with postprandial distress syndrome, in the subgroup with moderate to severe migraine, the severity of fullness and early satiation was significantly higher than in patients with mild or absent migraine. In patients with moderate to severe migraine, gastric accommodation, sensitivity thresholds and gastric emptying time were similar to patients with mild or no migraine. Conclusions In patients with functional dyspepsia and postprandial symptoms, migraine is a very frequent comorbidity. On clinical grounds, it is associated with an increased severity of fullness and early satiation and, on pathophysiological grounds, it seems correlated with postprandial hypersensitivity.

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