618 Postprandial Distress Syndrome But Not Epigastric Pain Syndrome in Functional Dyspepsia Predicts the New Onset of Gastroesophageal Reflux in the General Population (Kalixanda Study 10 Year Follow-Up)

Background. Functional dyspepsia is the prototype functional gastrointestinal disorder. This study was designed to determine its prevalence, subtypes, and risk factors associated with the subtypes.Method. Patients with upper gastrointestinal symptoms who presented for endoscopy were administered a questionnaire containing the functional dyspepsia and irritable bowel syndrome modules of the Rome III diagnostic criteria.Results. Of 192 patients who had functional dyspepsia, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes accounted for 79.2%, 62.5%, and 50%, respectively. Multivariate analysis of the risk factors showed that independent predictors of postprandial distress syndrome were alcohol and irritable bowel syndrome while irritable bowel syndrome was independent predictor of epigastric pain syndrome. Alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs were independent predictors of cooccurrence of postprandial distress syndrome and epigastric pain syndrome.Conclusion. Functional dyspepsia accounts for 62.5% of dyspepsia in a population of black African patients. Regarding symptomatology, epigastric pain syndrome, postprandial distress syndrome, and combination of the two subtypes account for 79.2%, 62.5%, and 50%, respectively. Risk factors for functional dyspepsia are irritable bowel syndrome, alcohol, smoking, and use of nonsteroidal anti-inflammatory drugs.

Download Full-text

903 Impaired Accommodation Is a Feature of Functional Dyspepsia Patients with Postprandial Distress Syndrome, Not with Epigastric Pain Syndrome

Gastroenterology ◽

10.1016/s0016-5085(09)60632-6 ◽

2009 ◽

Vol 136 (5) ◽

pp. A-140-A-141 ◽

Cited By ~ 1

Author(s):

Sebastien Kindt ◽

Raf Bisschops ◽

Rita Vos ◽

Lieselot Holvoet ◽

Philip Caenepeel ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome

Download Full-text

ROME III Functional Dyspepsia (FD) Criteria: Poor Discrimination Between Postprandial Distress Syndrome (PDS) and Epigastric Pain Syndrome (EPS)

Gastroenterology ◽

10.1016/s0016-5085(11)60098-x ◽

2011 ◽

Vol 140 (5) ◽

pp. S-25-S-26 ◽

Cited By ~ 1

Author(s):

Nimish B. Vakil ◽

Katarina Halling ◽

Börje Wernersson ◽

Lis Ohlsson

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome ◽

Rome Iii

Download Full-text

Prevalence and pathophysiology of post-prandial migraine in patients with functional dyspepsia

Cephalalgia ◽

10.1177/0333102419857596 ◽

2019 ◽

Vol 39 (12) ◽

pp. 1560-1568

Author(s):

Michele Di Stefano ◽

Ennio Pucci ◽

Emanuela Miceli ◽

Elisabetta Pagani ◽

Natascia Brondino ◽

...

Keyword(s):

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Gastric Accommodation ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome ◽

Gastric Emptying Time ◽

Early Satiation ◽

Severe Migraine

Background Migraine is a condition frequently associated with gastrointestinal disorders. Previous reports have shown the relationship between irritable bowel syndrome and migraine, but no data are yet available in patients with functional dyspepsia. We therefore evaluated whether alteration of gastric sensorimotor activity may be related to migraine. Methods Sixty patients affected by functional dyspepsia, 38 with postprandial distress syndrome and 22 with epigastric pain syndrome were enrolled in a cohort study. Presence and severity of dyspeptic symptoms, migraine presence and severity, gastric sensitivity thresholds during fasting and postprandial period, gastric accommodation and gastric emptying time were evaluated. Results In epigastric pain syndrome, 12/22 (54%) patients suffered from migraine and this condition was never correlated with meal ingestion. In postprandial distress syndrome patients, 29/38 (76%) suffered from migraine, in 26/29 (89%) its onset was considered as meal-related, and migraine severity was significantly correlated with postprandial modification of the gastric discomfort threshold (r = −0.73; p < 0.001). In patients with postprandial distress syndrome, in the subgroup with moderate to severe migraine, the severity of fullness and early satiation was significantly higher than in patients with mild or absent migraine. In patients with moderate to severe migraine, gastric accommodation, sensitivity thresholds and gastric emptying time were similar to patients with mild or no migraine. Conclusions In patients with functional dyspepsia and postprandial symptoms, migraine is a very frequent comorbidity. On clinical grounds, it is associated with an increased severity of fullness and early satiation and, on pathophysiological grounds, it seems correlated with postprandial hypersensitivity.

Download Full-text

Tu1208 Prevalence of Antral Gastritis in the General Population in Subjects With Rome III Functional Dyspepsia, Epigastric Pain Syndrome (EPS) and Post Prandial Distress Syndrome (PDS)

Gastroenterology ◽

10.1016/s0016-5085(15)32796-7 ◽

2015 ◽

Vol 148 (4) ◽

pp. S-822

Author(s):

Marjorie M. Walker ◽

Anna Andreasson ◽

Christina Falkeis ◽

Michael Vieth ◽

Nicholas J. Talley ◽

...

Keyword(s):

General Population ◽

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Antral Gastritis ◽

Epigastric Pain Syndrome ◽

Rome Iii

Download Full-text

Modern aspects of the pathogenesis and treatment of dyspepsia

Medical Council ◽

10.21518/2079-701x-2020-15-40-46 ◽

2020 ◽

pp. 40-46

Author(s):

V. V. Tsukanov ◽

A. V. Vasyutin ◽

Ju. L. Tonkikh

Keyword(s):

Helicobacter Pylori ◽

Functional Dyspepsia ◽

Distress Syndrome ◽

Epigastric Pain ◽

Pain Syndrome ◽

Diagnostic Procedures ◽

Complex Problem ◽

Current Data ◽

Postprandial Distress Syndrome ◽

Epigastric Pain Syndrome

A review of current data suggests that the attention to the problem of dyspepsia is huge. The definition of functional dyspepsia was given in the Rome IV criteria, according to which two of its main options are distinguished – epigastric pain syndrome and postprandial distress syndrome. The term “uninvestigated dyspepsia” is important, which means the presence of dyspepsia symptoms in patients who have not performed diagnostic procedures to identify the organic causes of the pathology. The prevalence of uninvestigated dyspepsia in the world is about 21%. The prevalence of functional dyspepsia is significantly lower than the prevalence of uninvestigated dyspepsia and fluctuates around 10%. The risk factors for dyspepsia are usually tobacco smoking, non-steroidal anti-inflammatory drugs and/or aspirin, and Helicobacter pylori infection. The concept of the pathogenesis of functional dyspepsia undergoes significant changes. By analogy with the pathophysiology of irritable bowel syndrome, lesions of the relationship between the modulation of the cerebral cortex and the signal system of the gastroduodenal zone, the association of sluggish immune inflammation in the duodenum with motility and sensory activity of the stomach are most actively studied. The treatment of functional dyspepsia is a complex problem and changes after new ideas about its pathogenesis. Modern meta-analyzes have made it possible to expand the indications for the proton pump inhibitors administration, which can be actively used not only for the treatment of epigastric pain syndrome, but also for postprandial distress syndrome. Along with the required Helicobacter pylori eradication, there are reasons for the use of probiotics and antibiotics for the dyspepsia treatment.

Download Full-text