Su1490 CHARACTERIZATION OF PANCREATIC INTRADUCTAL PAPILLARY NEOPLASM-DERIVED CANCER, MUCINOUS CYSTIC NEOPLASM-DERIVED CANCER, AND ADENOCARCINOMA: NATIONAL SURVIVAL OUTCOMES DATA

2020 ◽  
Vol 158 (6) ◽  
pp. S-600-S-601
Author(s):  
Daryl Ramai ◽  
Mohamed Barakat ◽  
Amaninder J. Dhaliwal ◽  
Mohamed M. Abdelfatah
Keyword(s):  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Survival Outcomes ◽  
Intraductal Papillary Neoplasm ◽  
National Survival ◽  
Papillary Neoplasm

scholarly journals Mucinous cystic neoplasm of the liver with biliary communication: an exception to the current classification

2019 ◽  
Vol 12 (1) ◽  
pp. bcr-2018-227063 ◽  
Author(s):  
Santhosh Anand ◽  
Sandip Chandrasekar ◽  
Kalayarasan Raja ◽  
Biju Pottakkat
Keyword(s):  
Who Classification ◽  
Mucinous Cystadenoma ◽  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Cystic Neoplasms ◽  
Intraductal Papillary Neoplasm ◽  
Rare Tumours ◽  
Current Classification ◽  
Biliary Communication ◽  
Papillary Neoplasm

Cystic neoplasms of the liver are rare tumours. According to the recent WHO classification, they are classified into mucinous cystic neoplasm and intraductal papillary neoplasm based on the presence of ovarian-like stroma and biliary communication. We report two rare cases of mucinous cystadenoma of the liver with biliary communication and discuss the shortcomings of current classification.

scholarly journals Cystic and Papillary Neoplasm at the Hepatic Hilum Possibly Originating in the Peribiliary Glands

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Takashi Miyata ◽  
Katsuhiko Uesaka ◽  
Yasuni Nakanuma
Keyword(s):  
Mucinous Cystic Neoplasm ◽  
Cystic Tumor ◽  
Cystic Neoplasm ◽  
Endoscopic Retrograde ◽  
Cystic Neoplasms ◽  
Intraductal Papillary Neoplasm ◽  
Hepatic Hilum ◽  
Left Hepatic Trisectionectomy ◽  
Peribiliary Glands ◽  
Papillary Neoplasm

Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and cystic intraductal papillary neoplasm of the bile duct. We herein report two cases of cystic and papillary neoplasm of the liver which differed from the abovementioned types.Case  1.A 70-year-old man. Radiologically, a cystic tumor measuring 20 mm in diameter was found at the hepatic hilum. Right hepatectomy was performed under a diagnosis of intrahepatic cholangiocarcinoma (iCCA) based on the imaging findings.Case  2.A 70-year-old man. Radiologically, a cystic tumor measuring 60 mm in diameter was found at the hepatic hilum. Under a diagnosis of iCCA, left hepatic trisectionectomy was performed. In both cases, endoscopic retrograde cholangiography did not demonstrate communication between the cystic tumor and adjacent bile ducts. Pathologically, these two tumors were cystic neoplasms located at the hepatic hilum and were morphologically characterized by an intracystic papillary neoplasm composed of diffuse high-grade dysplasia and associated with an invasive carcinoma. Ovarian-like stroma was not found in the capsule of these tumors. Interestingly, there were peribiliary glands near these tumors, and MUC6 was expressed in these papillary neoplasms as well as in the peribiliary glands. These neoplasms might have arisen from the peribiliary glands.

scholarly journals Surgical resection for hepatic space occupying lesions: a histopathological analysis

2017 ◽  
Vol 5 (5) ◽  
pp. 2215
Author(s):  
Vani M. ◽  
Jeena Sam Kachappilly ◽  
Geetha K.
Keyword(s):  
Hepatic Resection ◽  
Liver Tumors ◽  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Malignant Neoplasms ◽  
Histopathological Analysis ◽  
Neoplastic Diseases ◽  
Intraductal Papillary Neoplasm ◽  
Neoplastic Lesions ◽  
Malignant Liver

Background: Hepatic resections are done for both neoplastic and non-neoplastic diseases of liver with malignancies constituting a major share of cases. The objective of this study was to assess the various neoplatic and non-neoplastic lesions in hepatic resection specimens and to categorize the various histopathological types of primary and secondary liver tumors.Methods: The study was conducted in the Department of Pathology, Academy of Medical sciences, Pariyaram. This was a hospital based study which included 79 patients who underwent hepatic resection for space occupying lesions over a period of 5 years from January 2012 to December 2016. IHC was performed in cases with diagnostic dilemma.Results: Of the 79 cases, there were 45 males and 34 females with the age range of 22-85 years. There were 70 neoplastic lesions out of which 11 were benign with 6 cavernous hemangiomas, 3 hepatic adenomas and one each of intraductal papillary neoplasm and mucinous cystic neoplasm. Among the 59 malignant lesions, hepatocellular carcinomas predominated followed by metastatic malignancies and cholangiocarcinomas. Of the metastatic malignancies, adenocarcinoma from gastrointestinal primary was the commonest followed by metastatic gastrointestinal stromal tumor.Conclusions: Liver is a frequent site for many neoplastic and non-neoplastic diseases with malignant neoplasms forming the major bulk. Non-neoplastic lesions like simple liver cysts and focal nodular hyperplasia showed female predominance while benign neoplasms like cavernous hemangioma and hepatic adenomas were seen exclusively in females. Of the malignant liver tumors, hepatocellular carcinoma was the commonest followed by metastatic malignancy, gastrointestinal tract being the commonest source of primary tumor.

scholarly journals Diagnosis and Management of Cystic Lesions of the Pancreas

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Niraj Jani ◽  
Murad Bani Hani ◽  
Richard D. Schulick ◽  
Ralph H. Hruban ◽  
Steven C. Cunningham
Keyword(s):  
Pancreatic Pseudocyst ◽  
Mucinous Cystic Neoplasm ◽  
Cystic Neoplasm ◽  
Pancreatic Cysts ◽  
Ethanol Ablation ◽  
Fluid Analysis ◽  
Serous Cystic Neoplasm ◽  
Papillary Neoplasm ◽  
Associated Mass

Pancreatic cysts are challenging lesions to diagnose and to treat. Determining which of the five most common diagnoses—pancreatic pseudocyst, serous cystic neoplasm (SCN), solid pseudopapillary neoplasm (SPN), mucinous cystic neoplasm (MCN), and intraductal mucinous papillary neoplasm (IPMN)—is likely the correct one requires the careful integration of many historical, radiographic, laboratory, and other factors, and management is markedly different depending on the type of cystic lesion of the pancreas. Pseudocysts are generally distinguishable based on historical, clinical and radiographic characteristics, and among the others, the most important differentiation is between the mucin-producing MCN and IPMN (high risk for cancer) versus the serous SCN and SPN (low risk for cancer). EUS with FNA and cyst-fluid analysis will continue to play an important role in diagnosis. Among mucinous lesions, those that require treatment (resection currently) are any MCN, any MD IPMN, and BD IPMN larger than 3 cm, symptomatic, or with an associated mass, with the understanding that SCN or pseudocysts may be removed inadvertently due to diagnostic inaccuracy, and that a certain proportion of SPN will indeed be malignant at the time of removal. The role of ethanol ablation is under investigation as an alternative to resection in selected patients.

Pancreatic Lymphoepithelial Cyst Showing Multiple Floating Ball-like Appearances

2016 ◽  
Vol 25 (2) ◽  
pp. 239-242 ◽  
Author(s):  
Hiroyuki Matsubayashi ◽  
Yoshiko Aikawa ◽  
Teiichi Sugiura ◽  
Keiko Sasaki ◽  
Kinichi Hotta ◽  
...  
Keyword(s):  
Mucinous Cystic Neoplasm ◽  
Carbohydrate Antigen ◽  
Cystic Neoplasm ◽  
Lymphoid Tissues ◽  
Lymphoepithelial Cyst ◽  
Pancreatic Lesion ◽  
Multilocular Cyst ◽  
Intraductal Papillary Neoplasm ◽  
Diffusion Weighted ◽  
Floating Ball

A lymphoepithelial cyst (LEC) is a rare pancreatic lesion, histologically showing squamous epithelia, dense lymphoid tissues, and a keratin substance. Cross-section images of the pancreatic LEC typically show a well demarcated unilocular or multilocular cyst without a solid component. Here we report a rare case of pancreatic LEC in which multiple floating ball-like components were depicted via endoscopic ultrasound. The ball-like components were also depicted by various imaging methods such as computed tomography (CT) showing low-density components, T1-weighted magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) showing high-intensity components, and T2-weighted MRI showing low-intensity components. The ball-like components in all images were not well enhanced. Laparotomic cyst resection was performed, and the surgical material revealed keratin balls inside the pancreatic LEC. Keratin components of a pancreatic LEC can take a liquid, sludge, or solid form. Clinicians must be aware of the variations in imaging to facilitate the differentiation and management of pancreatic cystic lesions. Abbreviations: CA 19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; DWI: diffusion-weighted image; LEC: lymphoepithelial cyst; IPMN: intraductal papillary neoplasm; MCN: mucinous cystic neoplasm.

scholarly journals Tubulocystic Carcinoma of the Bile Duct

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Masahiro Takeuchi ◽  
Yoshitaka Sakamoto ◽  
Hirotsugu Noguchi ◽  
Sohsuke Yamada ◽  
Keiji Hirata
Keyword(s):  
Differential Diagnosis ◽  
Bile Duct ◽  
Japanese Patient ◽  
Cystic Neoplasm ◽  
Radical Operation ◽  
Intraductal Papillary Neoplasm ◽  
Old Japanese ◽  
Papillary Neoplasm ◽  
Tubulocystic Carcinoma

Tubulocystic carcinoma of the bile duct is extremely rare and has not been reported in the literature. We reported a case of cystic neoplasm of the liver with distinct histopathological features that could not be clearly classified as of either mucinous or intraductal papillary neoplasm. A 68-year-old Japanese patient had a multicystic biliary tumor within the liver. This tumor was detected on follow-up of polymyalgia rheumatica. The exophytic, multicystic, 35 × 50 mm mass was composed of complex tubulocystic structures. We initially suspected cystadenocarcinoma of the liver and performed radical operation. However, pathology ultimately showed it to be very rare tubulocystic carcinoma that derived from the bile duct. We reviewed the literature and describe the process of our differential diagnosis.

scholarly journals Infrequent intrahepatic cystic neoplasm: dilemmas in diagnosis and management

2019 ◽  
Vol 12 (5) ◽  
pp. e229058 ◽  
Author(s):  
Dattaraj Pradeep Budkule ◽  
Gunjan Shailesh Desai ◽  
Prasad Pande ◽  
Dattaprasanna R Kulkarni
Keyword(s):  
Frozen Section ◽  
Mucinous Cystic Neoplasm ◽  
Carbohydrate Antigen ◽  
Hepatic Cyst ◽  
Cystic Neoplasm ◽  
Intravenous Contrast ◽  
Female Population ◽  
Intraductal Papillary Neoplasm ◽  
Abdominal Symptoms ◽  
Cystic Liver

Biliary mucinous cystic neoplasm (BMCN) is a rare intrahepatic neoplasm comprising approximately 5% of cystic liver lesions. It can cause diagnostic dilemmas with most common differentials being complex hepatic cyst, hydatid cyst and intraductal papillary neoplasm of the bile duct. Affecting middle-aged female population, BMCN presents variedly ranging from vague abdominal symptoms to obstructive jaundice. Preoperative diagnosis is difficult. Preoperative CT scan with intravenous contrast and carbohydrate antigen 19.9 levels may give a clue towards the diagnosis. Intraoperative frozen section or cyst fluid aspiration cytology might help confirm the diagnosis. Fine needle aspirations should not be performed if BMCN is suspected, and intraoperative cyst spillage should be avoided to prevent tumour dissemination. We present here a case with a very atypical presentation of BMCN and review its present literature in brief.

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