Healthy lifestyle and work stress in nurses in time of the COVID -19 pandemic, at the National Institute of Neoplastic Diseases, Lima, 2020 [Estilo de vida saludable y estrés laboral en enfermera(o)s en tiempo de pandemia COVID -19, en el instituto nacio

Objective: Determine the healthy lifestyle and work stress in Nurses who care for patients with COVID -19, at the National Institute of Neoplastic Diseases, Lima, 2020. Study: Quantitative, correlational, cross-sectional approach and non-experimental design. Population: it was made up of the 65 nurses who work in the Covid-19 area. Instruments: 2 questionnaires were used: Healthy lifestyle, consisting of 3 dimensions: physical activity, eating habits, sleep dimension. Work stress, which consists of 3 dimensions: emotional exhaustion, depersonalization and personal fulfillment. Both instruments with Likert scale were validated by expert judgment with a reliability of 0.8 and 0.7 respectively. The results found that there is a correlation between both variables. In addition, it predominates in nurses who mostly have inadequate healthy lifestyles. Also, the moderate level of stress is a problem affected in their emotional health in times of pandemic. It is concluded that it is important before these health problems require the implementation of improvement plans to promote self-care and avoid occupational health problems.

Neutrophil Extracellular Traps (NETs) and Hypercoagulability in Plasma Cell Dyscrasias—Is This Phenomenon Worthy of Exploration?

Plasma cell dyscrasias (PCDs) are neoplastic diseases derived from plasma cells. Patients suffering from PCDs are at high risk of hypercoagulability and thrombosis. These conditions are associated with disease-related factors, patient-related factors, or the use of immunomodulatory drugs. As PCDs belong to neoplastic diseases, some other factors related to the cancer-associated hypercoagulability state in the course of PCDs are also considered. One of the weakest issues studied in PCDs is the procoagulant activity of neutrophil extracellular traps (NETs). NETs are web-like structures released from neutrophils in response to different stimuli. These structures are made of deoxyribonucleic acid (DNA) and bactericidal proteins, such as histones, myeloperoxidase, neutrophil elastase, and over 300 other proteins, which are primarily stored in neutrophil granules. NETs immobilize, inactivate the pathogens, and expose them to specialized cells of immune response. Despite their pivotal role in innate immunity, they contribute to the development and exacerbation of autoimmune diseases, trigger inflammatory response, or even facilitate the formation of cancer metastases. NETs were also found to induce activity of coagulation and are considered one of the most important factors inducing thrombosis. Here, we summarize how PCDs influence the release of NETs, and hypothesize whether NETs contribute to hypercoagulability in PCDs patients.

The development of the incidence of non-neoplastic diseases of the digestive system in adults evacuated from the 30-kilometer zone of the Chornobyl nuclear power plant during the post-accident observation period (1992–2016)

Objective: We analyzed the absolute risk of the development of the incidence of non-neoplastic diseases of the digestive system in adults evacuated from the 30-kilometer zone of the Chornobyl NPP over 1992–2016 epidemiological surveillance. Materials and methods: For the epidemiological study of the incidence of non-neoplastic diseases of the digestive system in the evacuated from the 30-kilometer Chornobyl zone after the Chornobyl accident in 1992–2016 we formed a cohort of 7,143 people aged 18 years and older (2,198 men and 4,945 women). To study the features of the incidence of diseases of the digestive system over the years of observation, we calculated the epidemiological indicator - the absolute risk of development (AR). Results: During 1992–2016, 13,532 cases of the diseases of the digestive system: 3,298 (24.37%) – in men; 10,234 (75.63%) - in women) were revealed for the first time. The absolute risk of the development of digestive diseases makes up 467.64 ± 2.93 cases per 103 man-years of observation (further cases/103 man-years). It was found that 91.05% (12,321 cases) with an absolute risk of 425.32 ± 5.89 93 cas./103 man-years ( 423.22 ± 5.89- in men, 426.19 ± 3, 34 - in women) belonged to the class of the diseases of digestive system (C00-C93). Mostly diseases of oral cavity, salivary glands and jaws (C00 – C14) (200.63 ± 4.77 cases/103 man-years), esophageal diseases, stomach and duodenum (C20 – C31) (146.26 ± 4.21 93) were manifested. Significant loss of health was also caused by the diseases of the gallbladder, biliary tract and pancreas (C83–C87) (50.23 ± 2.60 93), liver disease (C70-C77) – (22.44 ± 1.76 93), non-infectious enteritis and colitis (C50–C52) – (3.93 ± 8.75), other intestinal diseases (C55–C63) – (1.83 ± 0.51) respectively. Irrespective of gender, the development of the incidence of non-neoplastic diseases of the digestive system is characterized by the identity of the diseases and the ratio of their values to the total cohort. However, women suffered more from the diseases of the gallbladder, biliary tract and pancreas, diseases of the oral cavity, men – from the diseases of esophagus, stomach and duodenum. Conclusions: 1. The revealed features of the development of digestive diseases in the evacuated from the 30-kilometer zone of the Chornobyl NPP (high absolute risks of diseases of oral cavity, salivary glands and jaws (C00–C14), diseases of esophagus, stomach and duodenum (C20–C31), biliary diseases bladder, biliary tract and pancreas (C80–C87)) need the improvement of medico-social measures to provide qualitative treatment-and-preventive, rehabilitative care from the primary level of medical care. 2. It is necessary to conduct medico-educational work on radiation hygiene, regimen, food intake and dietary nutrition for the minimization of the development of established prior nosological forms in the evacuees from the 30-kilometer zone of the ChNPP.

Modulation of the Complement System by Neoplastic Disease of the Central Nervous System

The complement system is a highly conserved component of innate immunity that is involved in recognizing and responding to pathogens. The system serves as a bridge between innate and adaptive immunity, and modulation of the complement system can affect the entire host immune response to a foreign insult. Neoplastic diseases have been shown to engage the complement system in order to evade the immune system, gain a selective growth advantage, and co-opt the surrounding environment for tumor proliferation. Historically, the central nervous system has been considered to be an immune-privileged environment, but it is now clear that there are active roles for both innate and adaptive immunity within the central nervous system. Much of the research on the role of immunological modulation of neoplastic disease within the central nervous system has focused on adaptive immunity, even though innate immunity still plays a critical role in the natural history of central nervous system neoplasms. Here, we review the modulation of the complement system by a variety of neoplastic diseases of the central nervous system. We also discuss gaps in the current body of knowledge and comment on future directions for investigation.

The Role of Bisphosphonates in Childhood Diseases

Bisphosphonates have found in recent years an increasingly wide application in adult neoplastic diseases and osteoporosis. Their mechanism of action is based on the inhibition of bone turnover favouring, in particular, the mineralization and the reduction of the frequency of the remodelling cycles. The fields of application of bisphosphonates in paediatric age are constantly evolving although new trials are needed to define the schedule of administration and their long-term side effects.

Non-neoplastic morbidity, disability, mortality in adult population at radioactively contaminated territories of Ukraine. Epidemiological research 1988-2016

Objective: We presented a comprehensive description of the changes in the health status of the adult population of radioactively contaminated territories of Ukraine depending on gender and age at the date of the Chornobyl accident on the basis of cohort epidemiological studies after accident. Materials and methods: The epidemiological analysis of non-neoplastic morbidity, disability, mortality in the residents of radioactively contaminated territories (RCT) aged 18-60 years old at the date of the Chornobyl accident (65,189 people) was conducting during 1988-2016 for five-year observation periods and by eight classes of ICD-10. We applied the methods of mathematical and statistical analysis. Results: During 1988-2016, 90590 (100%) cases of non-neoplastic morbidity (34.94% in men and 65.06% in women), 11153 (100%) cases of disability (38.22% and61.78%, respectively), and 11586 (100%) cases of mortality(50,42% and 49,58%, respectively)were detected in the residents of the RCT for the first time as a result of epidemiological study. Most of the victims suffered from the nosological forms of the nosological forms of respiratory, circulatory and digestive systems, which made up 67.43% in the structure of non-neoplastic morbidity. Diseases of circulatory, endocrine and nervous systems (87.92%) were the main factors of disability and diseases of circulatory system (89.49%) - of mortality. The gender dependence of the development of the incidence of non-neoplastic diseases, disability and mortality due to them were established. The indices of mortality (116.08, ID/103 man-years of observation) and disability (13.57)in females significantly exceeded the males’ ones (86.57 and 11.65, respectively). But males had a higher mortality rate (16.01 vs. - 11.32). Changes in the incidence rates of non-neoplastic diseases, disability and mortality due to them throughout the observation period were characterized by a divergence of vectors: morbidity decreased, and disability and mortality increased simultaneously. The intersection of the dynamics of the mortality of non-neoplastic diseases with disability and mortality through those diseases was identified in 2008-2012. Conclusions 1. During epidemiological surveillance in 1988-2016, in the residents of RCT aged 18-60 years old on the date of the Chornobyl accident epidemiological surveillance, the non-neoplastic morbidity was formed mainly due to the significant development of diseases of the respiratory, circulatory and digestive systems, which together made up 67.43%. Non-neoplastic diseases of the circulatory, endocrine and nervous systems (87.92) were the main causes of disability, diseases of circulatory system (89.49%) - of mortality. 2. The gender dependence of the development of the morbidity of non-neoplastic diseases, disability and mortality in the residents of RCT over the thirty-year observation period was established. Diseases of the circulatory system were the main causes of disability and mortality. In males, disability and mortality were caused by the mental and behavioral disorders, diseases of respiratory and digestive systems, in females - by the diseases of nervous and urogenital systems. 3. In the residents of RCT, regardless of gender, over the years of observation, a feature of the development of morbidity, disability and mortality due to them was established, it was in the significant reduction of the incidence of diseases in 2008-2016, due to the increase of disability and mortality of the suffered, especially in 2008-2016, in comparison with the previous years, i.e. in 22-30 years after the Chornobyl accident. 4. Summarizing the obtained data, it is important to continue the epidemiological studies of the health status of the residents of RCT (non-neoplastic morbidity, disability, mortality) for the determination of the impact of radiation on the development of the main forms of non-neoplastic diseases.

Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases

Exosomes are extracellular vesicles with a diameter between 40 and 120 nm, which are derived from all types of cells and released into all biological fluids, such as blood plasma, serum, urine, breast milk, colostrum, and more. They contain proteins, nucleic acids (mRNA, miRNA, other non-coding RNA, and DNA), and lipids. Exosomes represent a potentially accurate footprint of the miRNA profile of the parental cell and can therefore be proposed as potential and sensitive biomarkers, both in diagnosing and monitoring a variety of diseases in humans and animals. Liquid biopsy offers itself as a non-invasive or minimally invasive, pain-free, time-saving alternative to conventional tissue biopsy. Exosomes in both human and veterinary medicine find their major application in neoplastic diseases, but applications in the field of veterinary cardiology, nephrology, reproduction, parasitology, and regenerative medicine are currently being explored. Exosomes can therefore be used as diagnostic, prognostic, and, in some cases, therapeutic tools for several conditions. The aim of this review was to assess the current applications of exosomes in veterinary medicine, particularly in dog and cat patients.

Tumours of the nasopharynx, oropharynx, and hypopharynx

The pharynx (Greek for throat) is a 12 cm fibromuscular tube extending from the base of the skull above and fusing with the oesophagus below. The pharynx is the common entrance point for respiration and digestion and is divided into the three regions based on its anterior communications—the nasopharynx, the oropharynx and the laryngopharynx. Akin to three cups stacked one on top of the other, it is composed of three constrictor muscles inserting one into the other from superior to inferior, and three longitudinal muscles enabling elevation and dilatation. The pharynx serves the dual purpose of channelling food via the oesophagus into the digestive tract and enabling air to be directed via the larynx and trachea into the respiratory system. The pharyngeal structures also assist in vocalization of sounds and equalization of pressure within the middle ear. Management of pharyngeal neoplasia is challenging and is described in greater detail in published guidelines. This chapter summarizes the management of benign and malignant neoplastic diseases of the pharynx based on its anatomical subdivisions.

Identifying the deceiver: the non-neoplastic mimickers of genital system neoplasms

Tumors of the genital system are common and imaging is of crucial importance for their detection and diagnosis. Several non-neoplastic diseases may mimic these tumors and differential diagnosis may be difficult in certain cases. Misdiagnosing non-neoplastic diseases as tumor may prompt unnecessary medical treatment or surgical interventions. In this article, we aimed to present the imaging characteristics of non-neoplastic diseases of the male and female genital systems that may mimic neoplastic processes. Increasing awareness of the imaging specialists to these entities may have a severe positive impact on the management of these patients.