P735 Contraceptive efficacy of a combined oral contraceptive containing ethinylestradiol 20 mcg/drospirenone 3 mg administered in 24/4 regimen: a pooled analysis of four, open-label studies

2009 ◽  
Vol 107 ◽  
pp. S622-S622
Author(s):  
L. Anttila ◽  
M. Kunz ◽  
J. Marr
Keyword(s):  
Oral Contraceptive ◽  
Pooled Analysis ◽  
Contraceptive Efficacy ◽  
Open Label ◽  
Combined Oral Contraceptive

scholarly journals Efficacy of Acupuncture versus Combined Oral Contraceptive Pill in Treatment of Moderate-to-Severe Dysmenorrhea: A Randomized Controlled Trial

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Intira Sriprasert ◽  
Suparerk Suerungruang ◽  
Porntip Athilarp ◽  
Anuchart Matanasarawoot ◽  
Supanimit Teekachunhatean
Keyword(s):  
Randomized Controlled Trial ◽  
Oral Contraceptive ◽  
Side Effects ◽  
Controlled Trial ◽  
Oral Contraceptive Pill ◽  
Open Label ◽  
Intention To Treat ◽  
Combined Oral Contraceptive ◽  
Randomized Controlled ◽  
Pain Scores

This open-label randomized controlled trial was designed to compare the efficacy of acupuncture and combined oral contraceptive (COC) pill in treating moderate-to-severe primary dysmenorrhea. Fifty-two participants were randomly assigned to receive either acupuncture (n= 27) or COC (n= 25) for three menstrual cycles. Mefenamic acid was prescribed as a recue analgesic drug with both groups. The statistical approach used for efficacy and safety assessments was intention-to-treat analysis. By the end of the study, both treatments had resulted in significant improvement over baselines in all outcomes, that is, maximal dysmenorrhea pain scores, days suffering from dysmenorrhea, amount of rescue analgesic used, and quality of life assessed by SF-36 questionnaire. Over the three treatment cycles, COC caused greater reduction in maximal pain scores than acupuncture, while improvements in the remaining outcomes were comparable. Responders were defined as participants whose maximal dysmenorrhea pain scores decreased at least 33% below their baseline. Response rates following both interventions at the end of the study were not statistically different. Acupuncture commonly caused minimal local side effects but did not cause any hormone-related side effects as did COC. In conclusion, acupuncture is an alternative option for relieving dysmenorrhea, especially when COC is not a favorable choice.

Pituitary, ovarian and additional contraceptive effects of an estradiol-based combined oral contraceptive: results of a randomized, open-label study

Contraception ◽  
2013 ◽  
Vol 87 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Jan Endrikat ◽  
Susanne Parke ◽  
Dietmar Trummer ◽  
Marco Serrani ◽  
Ingrid Duijkers ◽  
...  
Keyword(s):  
Oral Contraceptive ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Combined Oral Contraceptive
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