scholarly journals Actions of second messengers synthesised by various spasmogenic agents and their relation to mechanical responses in dog tracheal smooth muscle

1990 ◽  
Vol 52 ◽  
pp. 96
Author(s):  
Hideaki Katsuyama ◽  
Satoshi Suzuki ◽  
Eiichiro Nishiye ◽  
Hirosi Kuriyama
Keyword(s):  
Smooth Muscle ◽  
Second Messengers ◽  
Tracheal Smooth Muscle ◽  
Mechanical Responses

Regulation of isotonic shortening velocity by second messengers in tracheal smooth muscle

1994 ◽  
Vol 266 (3) ◽  
pp. C684-C691 ◽  
Author(s):  
S. J. Gunst ◽  
M. H. al-Hassani ◽  
L. P. Adam
Keyword(s):  
Smooth Muscle ◽  
Light Chain ◽  
Second Messengers ◽  
Time Dependent ◽  
Tracheal Smooth Muscle ◽  
Shortening Velocity ◽  
Active Stress ◽  
Muscle Tissues ◽  
Mlc Phosphorylation ◽  
Isotonic Shortening

Evidence suggests that the mechanical behavior of smooth muscle tissues is regulated by Ca(2+)-dependent changes in the phosphorylation of the 20,000-Da light chain of myosin (MLC). However, alternative mechanisms activated by specific kinases may be involved in regulating the shortening velocity in some smooth muscle tissues. To determine how the activation of protein kinases A or C affects the regulation of the shortening velocity in canine tracheal smooth muscle, we evaluated the effects of forskolin (10(-5) M) and phorbol 12,13-dibutyrate (PDBu, 3 x 10(-6) M) on active stress, intracellular Ca2+ ([Ca2+]i), MLC phosphorylation, and isotonic shortening velocity during contractions elicited by 60 mM KCl. Forskolin depressed and PDBu increased active stress, [Ca2+]i, MLC phosphorylation, and shortening velocity; thus the effects of these agents on the shortening velocity may result from changes in Ca(2+)-dependent MLC phosphorylation. In contrast, the decline in velocity that occurred with time during tonic contractions elicited by K+ depolarization was not associated with significant changes in MLC phosphorylation; thus the time-dependent changes in shortening velocity may be regulated by a mechanism other than MLC phosphorylation.

scholarly journals Cyclic GMP-dependent but G-kinase-independent inhibition of Ca2+-dependent Cl−currents by NO donors in cat tracheal smooth muscle

1998 ◽  
Vol 511 (3) ◽  
pp. 719-731 ◽  
Author(s):  
Yoshiki Waniishi ◽  
Ryuji Inoue ◽  
Hiromitsu Morita ◽  
Noriyoshi Teramoto ◽  
Kihachiro Abe ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Cyclic Gmp ◽  
Tracheal Smooth Muscle ◽  
No Donors

scholarly journals Theophylline attenuates Ca2+ sensitivity and modulates BK channels in porcine tracheal smooth muscle

2003 ◽  
Vol 140 (5) ◽  
pp. 939-947 ◽  
Author(s):  
Shinji Ise ◽  
Junji Nishimura ◽  
Katsuya Hirano ◽  
Nobuyuki Hara ◽  
Hideo Kanaide
Keyword(s):  
Smooth Muscle ◽  
Bk Channels ◽  
Tracheal Smooth Muscle

scholarly journals l-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle

1990 ◽  
Vol 100 (4) ◽  
pp. 663-664 ◽  
Author(s):  
John F. Tucker ◽  
Sandra R. Brave ◽  
Litsa Charalambous ◽  
Adrian J. Hobbs ◽  
Alan Gibson
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Tracheal Smooth Muscle

Effects of levobupivacaine on isolated rat tracheal smooth muscle

2015 ◽  
Vol 29 (5) ◽  
pp. 809-812 ◽  
Author(s):  
Hung-Chi Chang ◽  
Shin-Yan Chen ◽  
Yu-Feng Huang ◽  
Feng-Lin Liu ◽  
Yih-Giun Cherng ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Tracheal Smooth Muscle ◽  
Rat Tracheal Smooth Muscle ◽  
Isolated Rat
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