Effect of a new HMG-CoA reductase inhibitor, atorvastatin, on lipids, apolipoproteins and lipoprotein particles in patients with elevated serum cholesterol and triglyceride levels

1997 ◽  
Vol 133 (1) ◽  
pp. 123-133 ◽  
Author(s):  
Petar Alaupovic ◽  
Therese Heinonen ◽  
Linda Shurzinske ◽  
Donald M Black
Keyword(s):  
Serum Cholesterol ◽  
Reductase Inhibitor ◽  
Elevated Serum ◽  
Hmg Coa Reductase ◽  
Lipoprotein Particles ◽  
Hmg Coa Reductase Inhibitor ◽  
Elevated Serum Cholesterol ◽  
Coa Reductase

Dose-Dependent Effect of Hydroxymethylglutaryl – Coenzyme A Reductase Inhibitor on Serum Cholesterol with Limited Dietary Restrictions: A Case Study

1993 ◽  
Vol 21 (2) ◽  
pp. 105-111
Author(s):  
S Okada ◽  
K Ichiki ◽  
S Tanokuchi ◽  
Z Ota
Keyword(s):  
Serum Cholesterol ◽  
Reductase Inhibitor ◽  
Coenzyme A ◽  
Cholesterol Biosynthesis ◽  
Dependent Diabetes Mellitus ◽  
Hmg Coa Reductase ◽  
Dietary Restrictions ◽  
Hmg Coa Reductase Inhibitor ◽  
Coa Reductase ◽  
Dose Dependent

Hydroxymethylglutaryl–coenzyme A (HMG–CoA) reductase inhibitor (pravastatin sodium) can selectively inhibit cholesterol biosynthesis in the liver and may lower serum cholesterol concentrations even where there are no particular dietary restrictions. A 72-year old housewife with non-insulin-dependent diabetes mellitus complicated by hyperlipaemia type IIb, who did not follow directions for diet therapy or kinesitherapy, was administered HMG–CoA reductase inhibitor. The initial dose of 10 mg/day HMG–CoA reductase inhibitor was increased by 10 mg/day every 4 weeks to 30 mg/day, maintained at 30 mg/day for 8 weeks and then reduced gradually until discontinuation after a further 27 weeks. Test results showed the changes in low-density lipoprotein cholesterol and apoprotein B to be dose-dependent. The findings represent the first clinical evidence that hypercholesterolaemia can be adequately managed by the use of HMG–CoA reductase inhibitor, even when no specific dietary restrictions are imposed, and may contribute to improvements in the quality of daily life for many patients suffering from hyperlipaemia type IIb.

Effects of an HMG-CoA reductase inhibitor, simvastatin, on human myeloma cells

2004 ◽  
Author(s):  
Takemi Otsuki ◽  
Haruko Sakaguchi ◽  
Tamayo Hatayama ◽  
Tomohiro Fujii ◽  
Takayuki Tsujioka ◽  
...  
Keyword(s):  
Reductase Inhibitor ◽  
Hmg Coa Reductase ◽  
Myeloma Cells ◽  
Hmg Coa Reductase Inhibitor ◽  
Coa Reductase ◽  
Human Myeloma Cells

Treatment of hypercholesterolemia with the HMG CoA reductase inhibitor, simvastatin

1989 ◽  
Vol 3 (2) ◽  
pp. 219-227 ◽  
Author(s):  
GMB Berger ◽  
AD Marais ◽  
HC Seftel ◽  
SG Baker ◽  
D Mendelsohn ◽  
...  
Keyword(s):  
Reductase Inhibitor ◽  
Hmg Coa Reductase ◽  
Hmg Coa Reductase Inhibitor ◽  
Coa Reductase

Serum lipoprotein Lp(a) concentrations are not influenced by an HMG CoA reductase inhibitor

1988 ◽  
Vol 66 (10) ◽  
pp. 462-463 ◽  
Author(s):  
J. Thiery ◽  
V. W. Armstrong ◽  
J. Schleef ◽  
C. Creutzfeldt ◽  
W. Creutzfeldt ◽  
...  
Keyword(s):  
Reductase Inhibitor ◽  
Serum Lipoprotein ◽  
Hmg Coa Reductase ◽  
Hmg Coa Reductase Inhibitor ◽  
Coa Reductase
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