scholarly journals The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.

1993 ◽  
Vol 268 (6) ◽  
pp. 4276-4280
Author(s):  
C. Alarcón ◽  
B. Lincoln ◽  
C.J. Rhodes
Keyword(s):  
Pancreatic Islets ◽  
Proprotein Convertase ◽  
Proinsulin Biosynthesis ◽  
Rat Pancreatic Islets

Stimulation of Proinsulin Biosynthesis by K+ in Rat Pancreatic Islets

Endocrine ◽  
2004 ◽  
Vol 23 (1) ◽  
pp. 51-58 ◽  
Author(s):  
Willy J. Malaisse ◽  
Ying Zhang ◽  
Jésus Cancelas ◽  
Pablo G. Prieto ◽  
Elisabeth Olivares ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Proinsulin Biosynthesis ◽  
Rat Pancreatic Islets ◽  
Stimulation Of

scholarly journals Metabolic signals produced by purine ribonucleosides stimulate proinsulin biosynthesis and insulin secretion

1978 ◽  
Vol 170 (3) ◽  
pp. 461-467 ◽  
Author(s):  
K Jain ◽  
J Logothetopoulos
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islets ◽  
Cell Receptors ◽  
Purine Bases ◽  
Rat Islets ◽  
Proinsulin Biosynthesis ◽  
Rat Pancreatic Islets ◽  
Mouse Pancreatic Islets ◽  
Mouse Islets ◽  
Specific Inhibitors

Inosine, guanosine and adenosine strongly stimulated proinsulin biosynthesis and insulin secretion in isolated mouse pancreatic islets. None of the purine ribonucleosides stimulated insulin secretion in rat islets, although as reported [jain & Logothetopoulos (1977) Endocrinilogy 100, 923-927] inosine and guanosine, but no adenosine, were potent stimulants of proinsulin biosynthesis in this species. The purine bases had no effect in either species. D-Ribose, which enhanced proinsulin biosynthesis at 0.3 and 0.6 mM but not at 5mM in rat pancreatic islets [jain & Logothetopoulos (1977) Endocrinology 100, 923-927], produced no secretory signals in rat islets and was without any effect on proinsulin biosynthesis and insulin secretion in mouse islets. The rates of oxidation of 14C-labelled purine ribonucleosides and D-ribose in islets of the two species correlated well with their effectiveness as inducers of insulin secretion and proinsulin biosynthesis. Specific inhibitors of purine ribonucleoside phosphorylase, adenosine deaminiase and of purine ribonucleoside transport suppressed the stimulatory effects of nucleosides in pancreatic islets without altering the effect of D-glucose. The same inhibitors also markedly diminished the oxidation rats of the labelled purine ribonucleosides. The experiments clearly indicate that porinsulin biosynthesis and insulin secretion are modulated through metabolic signals and not through interactions of intact substrate molecules with cell receptors.

scholarly journals Glucose decreases extracellular adenosine levels in isolated mouse and rat pancreatic islets

Islets ◽  
2012 ◽  
Vol 4 (1) ◽  
pp. 64-70 ◽  
Author(s):  
Gary K. Yang ◽  
Paul E. Squires ◽  
Faming Tian ◽  
Timothy J. Kieffer ◽  
Yin Nam Kwok ◽  
...  
Keyword(s):  
Pancreatic Islets ◽  
Extracellular Adenosine ◽  
Rat Pancreatic Islets

cAMP enhances insulin secretion by an action on the ATP-sensitive K+ channel-independent pathway of glucose signaling in rat pancreatic islets

Diabetes ◽  
1999 ◽  
Vol 48 (5) ◽  
pp. 1006-1012 ◽  
Author(s):  
H. Yajima ◽  
M. Komatsu ◽  
T. Schermerhorn ◽  
T. Aizawa ◽  
T. Kaneko ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pancreatic Islets ◽  
K Channel ◽  
Glucose Signaling ◽  
Rat Pancreatic Islets
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