epigenetic control
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2022 ◽  
Vol 52 ◽  
pp. 78-88
Author(s):  
Rui Guo ◽  
Benjamin E Gewurz

2022 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Jasmina Al-Mousawi ◽  
Ana Boskovic

2021 ◽  
Vol 7 (51) ◽  
Author(s):  
Matthew R. Brown ◽  
Satish K. Sen ◽  
Amelia Mazzone ◽  
Tracy K. Her ◽  
Yuning Xiong ◽  
...  

Obesity ◽  
2021 ◽  
Vol 29 (12) ◽  
pp. 2013-2025
Author(s):  
Serena Barilla ◽  
Eckardt Treuter ◽  
Nicolas Venteclef
Keyword(s):  

Impact ◽  
2021 ◽  
Vol 2021 (8) ◽  
pp. 6-8
Author(s):  
Takeshi Yamada ◽  
Yuya Arakawa

Adoptive immunotherapy can be used to treat intractable cancers but this involves taking T cells from a patient and growing them in a laboratory and, once outside the body, the T cells can fall into a state of exhaustion. This is a barrier that Professor Takeshi Yamada, Department of Medical Technology, Immunology, Ehime Prefectural University of Health Sciences, Japan, is seeking to overcome. His work involves establishing a better understanding of the mechanisms of T cell exhaustion, which are currently not well known. Yamada and his team are focusing on intracellular energy metabolism and epigenetic control in mouse models with a view to finding a way to inhibit T cell exhaustion. The researchers are developing protocols to improve T cell function for immunotherapy by controlling epigenetic changes involved in glutamine metabolism, which induces T cell exhaustion. As previous research has focused on activating and proliferating tumour-specific T cells, Yamada's approach, with a focus on epigenetic control, is novel. The team is interested in T cell differentiation and its links to T cell exhaustion and so they are exploring the mechanism of T cell differentiation via intracellular energy metabolism and epigenetic changes and how this can impact on exhaustion. The researchers previously clarified that the enhancement of glutamine metabolism that occurs during the activation of T cell cultures causes epigenetic changes that induce T cell exhaustion and are expanding on this finding in order to develop a method to suppress T cell exhaustion via epigenetic control.


2021 ◽  
pp. 1-10
Author(s):  
María Carolina Manotas ◽  
Daniel Mauricio González ◽  
Camila Céspedes ◽  
Catalina Forero ◽  
Adriana Patricia Rojas Moreno

Puberty is a complex transitional phase in which reproductive capacity is achieved. There is a very wide variation in the age range of the onset of puberty, which follows a familial, ethnic, and sex pattern. The hypothalamic-pituitary-gonadal axis and several genetic, environmental, and nutritional factors play an important role in the onset of and throughout puberty. Recently, there has been significant progress in identifying factors that affect normal pubertal timing. Different studies have identified single nucleotide polymorphisms (SNPs) that affect pubertal timing in both sexes and across ethnic groups. Single genes are implicated in both precocious and delayed puberty, and epigenetic mechanisms have been suggested to affect the development and function of the GnRH neuronal network and responsiveness of end organs. All these factors can influence normal puberty timing, precocious puberty, and delayed puberty. The objective of this review is to describe recent findings related to the genetic and epigenetic control of puberty and highlight the need to deepen the knowledge of the regulatory mechanisms of this process in the normal and abnormal context.


2021 ◽  
Vol 12 ◽  
Author(s):  
Satish kumar R. Noonepalle ◽  
Lidia Karabon ◽  
Katherine B. Chiappinelli ◽  
Alejandro Villagra

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