scholarly journals Interactions between the muscarinic receptors, sodium channels, and guanine nucleotide-binding protein(s) in rat atria.

1986 ◽  
Vol 261 (27) ◽  
pp. 12498-12505
Author(s):  
M Cohen-Armon ◽  
M Sokolovsky
Keyword(s):  
Sodium Channels ◽  
Muscarinic Receptors ◽  
Binding Protein ◽  
Protein S ◽  
Nucleotide Binding ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding Protein ◽  
Rat Atria ◽  
Guanine Nucleotide Binding ◽  
Nucleotide Binding Protein

scholarly journals Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein

1986 ◽  
Vol 239 (3) ◽  
pp. 567-574 ◽  
Author(s):  
T Sasaguri ◽  
M Hirata ◽  
T Itoh ◽  
T Koga ◽  
H Kuriyama
Keyword(s):  
Coronary Artery ◽  
G Protein ◽  
Binding Protein ◽  
Protein S ◽  
Nucleotide Binding ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding Protein ◽  
Guanine Nucleotide Binding ◽  
Pig Coronary Artery ◽  
Nucleotide Binding Protein

In an attempt to identify the nature of guanine nucleotide binding protein(s) (G-protein) involved in the acetylcholine (ACh)-induced (muscarinic) response of pig coronary-artery smooth muscle, we studied the effect of ADP-ribosylation of specific membrane protein(s) catalysed by islet-activating protein (IAP; pertussis toxin). The ACh-stimulated and guanine nucleotide-dependent activities of phosphatidylinositol 4,5-bisphosphate (PIP2) phosphodiesterase (PDE), assessed by the production of inositol 1,4,5-trisphosphate (IP3) from exogenously applied PIP2, were not modified, in either IAP-treated or non-treated cell homogenates used as the enzyme source. In intact tissues, pretreatment with up to 100 ng of IAP/ml inhibited neither the ACh-induced decrease in the amount of inositol phospholipids nor the increase in the amounts of phosphatidic acid and of inositol phosphates. IAP treatment increased the amount of cyclic AMP accumulated by isoprenaline. These observations suggest that G-protein which couples the muscarinic receptor to PIP2-PDE is insensitive to IAP. Such being the case, the nature of this protein(s) probably differs from that required for the regulation of adenylate cyclase activities (Ni or Gi).

Activation of immobilized, biotinylated choleragen A1 protein by a 19-kilodalton guanine nucleotide-binding protein

Biochemistry ◽  
1989 ◽  
Vol 28 (19) ◽  
pp. 7936-7940 ◽  
Author(s):  
Masatoshi Noda ◽  
Su Chen Tsai ◽  
Ronald Adamik ◽  
David A. Bobak ◽  
Joel Moss ◽  
...  
Keyword(s):  
Binding Protein ◽  
Nucleotide Binding ◽  
Guanine Nucleotide ◽  
Guanine Nucleotide Binding Protein ◽  
Guanine Nucleotide Binding ◽  
Nucleotide Binding Protein
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