scholarly journals The Effect of Adenylic Acid on Yeast Nicotinamide Adenine Dinucleotide Isocitrate Dehydrogenase, a Possible Metabolic Control Mechanism

1963 ◽  
Vol 238 (8) ◽  
pp. 2875-2881 ◽  
Author(s):  
James A. Hathaway ◽  
Daniel E. Atkinson
Keyword(s):  
Metabolic Control ◽  
Isocitrate Dehydrogenase ◽  
Nicotinamide Adenine Dinucleotide ◽  
Control Mechanism ◽  
Nicotinamide Adenine ◽  
Adenylic Acid

scholarly journals The effect of pH on the characteristics of the binding of nicotinamide–adenine dinucleotide by nicotinamide–adenine dinucleotide specific isocitrate dehydrogenase from pea mitochondria

1970 ◽  
Vol 116 (5) ◽  
pp. 819-824 ◽  
Author(s):  
G. F. Cox ◽  
D. D. Davies
Keyword(s):  
Isocitrate Dehydrogenase ◽  
Nicotinamide Adenine Dinucleotide ◽  
Maximum Velocity ◽  
Nicotinamide Adenine ◽  
Half Maximum ◽  
Ph Optimum ◽  
Effect Of Ph ◽  
Ph Values ◽  
Metabolic Significance

1. The effect of pH on the Vmax. and concentration of NAD+ at half-maximum velocity at a constant isocitrate concentration was examined, and the results were related to the requirements for binding of H+ ions to the enzyme. 2. The effect of varying the NAD+ concentration on the pH optimum with constant isocitrate concentration was studied. 3. A comparison has been made between the effect of isocitrate concentration on the characteristics of binding of NAD+ and the effect of NAD+ concentration on the characteristics of isocitrate binding at three different pH values. 4. The mechanistic and metabolic significance of these studies is considered.

Sign in / Sign up

Export Citation Format

Share Document