A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(19)49424-6 ◽

1993 ◽

Vol 268 (31) ◽

pp. 23055-23058

Author(s):

H Kong ◽

K Raynor ◽

K Yasuda ◽

S.T. Moe ◽

P.S. Portoghese ◽

...

Keyword(s):

Aspartic Acid ◽

Opioid Receptor ◽

Delta Opioid Receptor ◽

Agonist Binding ◽

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Site-directed mutagenesis of human beta-adrenergic receptors: substitution of aspartic acid-130 by asparagine produces a receptor with high-affinity agonist binding that is uncoupled from adenylate cyclase.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.85.15.5478 ◽

1988 ◽

Vol 85 (15) ◽

pp. 5478-5482 ◽

Author(s):

C. M. Fraser ◽

F. Z. Chung ◽

C. D. Wang ◽

J. C. Venter

Keyword(s):

Adenylate Cyclase ◽

Aspartic Acid ◽

Adrenergic Receptors ◽

Site Directed Mutagenesis ◽

Directed Mutagenesis ◽

Agonist Binding ◽

Beta Adrenergic Receptors ◽

Beta Adrenergic ◽

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ChemInform Abstract: 4-[(8-Alkyl-8-azabicyclo [3.2.1]octyl-3-yl)-3-arylanilino]-N,N-diethylbenzamides: High Affinity, Selective Ligands for the Delta Opioid Receptor Illustrate Factors Important to Antagonist Activity.

10.1002/chin.200039138 ◽

2000 ◽

Vol 31 (39) ◽

pp. no-no

Author(s):

James B. Thomas ◽

Robert N. Atkinson ◽

Richard B. Rothman ◽

Jason P. Burgess ◽

S. Wayne Mascarella ◽

...

Keyword(s):

Opioid Receptor ◽

Delta Opioid Receptor ◽

Antagonist Activity ◽

High Affinity ◽

Selective Ligands

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4-[(8-Alkyl-8-azabicyclo[3.2.1]octyl-3-yl)-3-arylanilino]- N , N -diethylbenzamides: high affinity, selective ligands for the delta opioid receptor illustrate factors important to antagonist activity

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(00)00209-2 ◽

2000 ◽

Vol 10 (11) ◽

pp. 1281-1284 ◽

Author(s):

James B Thomas ◽

Robert N Atkinson ◽

Richard B Rothman ◽

Jason P Burgess ◽

S.Wayne Mascarella ◽

...

Keyword(s):

Opioid Receptor ◽

Delta Opioid Receptor ◽

Antagonist Activity ◽

High Affinity ◽

Selective Ligands

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[D-ALA2]deltorphin II analogs with high affinity and selectivity for delta-opioid receptor

Biochemical and Biophysical Research Communications ◽

10.1016/s0006-291x(05)81138-6 ◽

1991 ◽

Vol 180 (2) ◽

pp. 822-827 ◽

Author(s):

Yusuke Sasaki ◽

Akihiro Ambo ◽

Kenji Suzuki

Keyword(s):

Opioid Receptor ◽

Delta Opioid Receptor ◽

High Affinity ◽

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A high affinity, highly selective ligand for the delta opioid receptor: [3H]-[D-PEN2, pCl-PHE4, D-PEN5]enkephalin

Life Sciences ◽

10.1016/0024-3205(89)90154-9 ◽

1989 ◽

Vol 45 (11) ◽

pp. 1001-1008 ◽

Author(s):

Linda K. Vaughn ◽

Richard J. Knapp ◽

Geza Toth ◽

Y.-P. Wan ◽

Victor J. Hruby ◽

...

Keyword(s):

Opioid Receptor ◽

Delta Opioid Receptor ◽

High Affinity ◽

Selective Ligand

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Promising Therapeutic Agents: Delta Opioid Receptor Agonists

The International Annals of Medicine ◽

10.24087/iam.2017.1.8.252 ◽

2017 ◽

Vol 1 (8) ◽

Author(s):

Amjad Hasan Bazzari ◽

Firas Hasan Bazzari

Keyword(s):

Opioid Receptor ◽

Therapeutic Agents ◽

Delta Opioid Receptor ◽

Receptor Agonists ◽

Opioid Receptor Agonists

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Faculty Opinions recommendation of Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1086845.539776 ◽

2007 ◽

Author(s):

Howard Fields

Keyword(s):

Receptor Antagonist ◽

Conditioned Place Preference ◽

Opioid Receptor ◽

Receptor Agonist ◽

Mu Opioid Receptor ◽

Place Preference ◽

Delta Opioid Receptor ◽

Bivalent Ligands ◽

Mu Opioid ◽

Opioid Receptor Agonist

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Faculty Opinions recommendation of A novel delta opioid receptor antagonist, SoRI-9409, produces a selective and long-lasting decrease in ethanol consumption in heavy-drinking rats.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1119600.577817 ◽

2008 ◽

Author(s):

George Breese ◽

Mary Katherine Kelm

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Heavy Drinking ◽

Ethanol Consumption ◽

Delta Opioid Receptor ◽

Opioid Receptor Antagonist

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Faculty Opinions recommendation of Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1124254.581403 ◽

2008 ◽

Author(s):

Ralf Jockers ◽

Angélique Levoye

Keyword(s):

Cell Surface ◽

Opioid Receptor ◽

Delta Opioid Receptor

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Levels of Delta-Opioid Receptor mRNA in Morphine-Tolerant Mice

Analgesia ◽

10.3727/107156995819564257 ◽

1995 ◽

Vol 1 (3) ◽

pp. 195-200 ◽

Author(s):

Benjamin Kest ◽

Shirzad Jenab ◽

Charles E. Inturrisi

Keyword(s):

Opioid Receptor ◽

Delta Opioid Receptor ◽

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