scholarly journals Characterization and nucleotide binding properties of a mutant dihydropteridine reductase containing an aspartate 37-isoleucine replacement.

1992 ◽  
Vol 267 (22) ◽  
pp. 15334-15339
Author(s):  
C.E. Grimshaw ◽  
D.A. Matthews ◽  
K.I. Varughese ◽  
M Skinner ◽  
N.H. Xuong ◽  
...  
Keyword(s):  
Nucleotide Binding ◽  
Dihydropteridine Reductase ◽  
Binding Properties

Techniques to examine nucleotide binding by pseudokinases

2013 ◽  
Vol 41 (4) ◽  
pp. 975-980 ◽  
Author(s):  
Isabelle S. Lucet ◽  
Jeffrey J. Babon ◽  
James M. Murphy
Keyword(s):  
Signal Transduction ◽  
Drug Targets ◽  
Nucleotide Binding ◽  
Biological Functions ◽  
Binding Properties ◽  
Catalytic Activities ◽  
Functional Studies ◽  
Signalling Molecules ◽  
Advantages And Disadvantages ◽  
Human Kinome

Approximately 10% of the human kinome has been classified as pseudokinases due to the absence of one or more of three motifs known to play key roles in the catalytic activities of protein kinases. Structural and functional studies are now emerging, reclassifying this ‘dead’ kinase family as essential signalling molecules that act as crucial modulators of signal transduction. This raises the prospect that pseudokinases may well represent an as-yet-unexplored class of drug targets. However, the extent to which nucleotide binding and catalytic activity contribute to the biological functions of pseudokinases remains an area of great controversy. In the present review, we discuss the advantages and disadvantages of the different methods employed to characterize the nucleotide-binding properties and activity of pseudokinases.

scholarly journals Amino acid residues conferring the nucleotide binding properties of N-acetyl-D-glucosamine 2-epimerase (renin binding protein)

2005 ◽  
Vol 26 (3) ◽  
pp. 117-121 ◽  
Author(s):  
Saori TAKAHASHI ◽  
Hironobu OGASAWARA ◽  
Kazuyuki HIWATASHI ◽  
Keishi HATA ◽  
Kazuyuki HORI ◽  
...  
Keyword(s):  
Amino Acid ◽  
Binding Protein ◽  
Nucleotide Binding ◽  
Amino Acid Residues ◽  
Binding Properties

scholarly journals ATP Binding Properties of the Nucleotide-binding Folds of SUR1

1999 ◽  
Vol 274 (52) ◽  
pp. 37479-37482 ◽  
Author(s):  
Michinori Matsuo ◽  
Noriyuki Kioka ◽  
Teruo Amachi ◽  
Kazumitsu Ueda
Keyword(s):  
Nucleotide Binding ◽  
Atp Binding ◽  
Binding Properties
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