Effect of efficiency improvement by injecting a sample at a lower carrier gas velocity in isothermal gas–liquid chromatography

2001 ◽  
Vol 919 (2) ◽  
pp. 357-361 ◽  
Author(s):  
Victor G Berezkin ◽  
Alexei B Lapin ◽  
Irina V Malyukova
Keyword(s):  
Liquid Chromatography ◽  
Gas Liquid Chromatography ◽  
Efficiency Improvement ◽  
Gas Velocity ◽  
Carrier Gas ◽  
Isothermal Gas ◽  
Carrier Gas Velocity

Measurement of thiamylal and thiopental in plasma by electron capture and flame photometric gas-liquid chromatography.

1977 ◽  
Vol 23 (7) ◽  
pp. 1306-1309 ◽  
Author(s):  
R H Smith ◽  
J A MacDonald ◽  
D S Thompson ◽  
W E Flacke
Keyword(s):  
Liquid Chromatography ◽  
Ethyl Acetate ◽  
Electron Capture ◽  
Internal Standard ◽  
Chromatographic Column ◽  
Gas Liquid Chromatography ◽  
Unchanged Drug ◽  
Chromatographic Procedure ◽  
Isothermal Gas ◽  
Liquid Chromatographic

Abstract We describe an isothermal gas-liquid chromatographic procedure developed for measuring thiamylal and thiopental in plasma. The unchanged drug is extracted into ethyl acetate from acidified plasma, together with an internal standard. The solvent is removed, the residue methylated, aliquots, diluted with benzene, are injected into a 183-cm gas-liquid chromatographic column containing 3% OV-17. Sensitivity of detection is in the nanogram to picogram range.

Simultaneous Measurement of Diphenylhydantoin and Primidone in Serum by Gas—Liquid Chromatography

1970 ◽  
Vol 16 (2) ◽  
pp. 107-110 ◽  
Author(s):  
M A Evenson ◽  
P Jones ◽  
B Darcey
Keyword(s):  
Liquid Chromatography ◽  
Clinical Chemistry ◽  
Chemistry Laboratory ◽  
Specific Method ◽  
Gas Liquid Chromatography ◽  
Serum Samples ◽  
Large Numbers ◽  
Clinical Chemistry Laboratory ◽  
Isothermal Gas

Abstract The need for simultaneous determination of the concentration of diphenylhydantoin (Dilantin) and primidone (Mysoline) in serum is frequently expressed to the clinical chemistry laboratory. Isothermal gas-liquid chromatography (GLC) has been used to develop a rapid, specific method. The method involves a single extraction and no derivative formation. The procedure is simple enough to be used with large numbers of samples. Detection limits for the method are 0.3 µg diphenylhydantoin per ml and 0.1 µg primidone per ml. The mean precision of the method is 6.2% and 4.8%, expressed as the coefficient of variation, for diphenylhydantoin and primidone, respectively. Barbiturates and glutethimide added to serum samples did not interfere with the analysis. The method has been used for more than 500 patients without interferences from metabolites, and meets all criteria for routine and emergency use.

Measurement of chloroprocaine and procaine in plasma by flame ionization gas-liquid chromatography.

1978 ◽  
Vol 24 (9) ◽  
pp. 1599-1602 ◽  
Author(s):  
R H Smith ◽  
M A Brewster ◽  
J A MacDonald ◽  
D S Thompson
Keyword(s):  
Liquid Chromatography ◽  
Internal Standard ◽  
Chromatographic Column ◽  
Gas Liquid Chromatography ◽  
Unchanged Drug ◽  
Flame Ionization ◽  
Chromatographic Procedure ◽  
Isothermal Gas ◽  
Liquid Chromatographic

Abstract We describe an isothermal gas-liquid chromatographic procedure developed for measuring procaine and chloroprocaine in plasma. The unchanged drug is extracted into toluene from alkalinized plasma, together with an internal standard. The solvent is removed, the residue redissolved in methanol, and aliquots are injected into a 91.5-cm gas-liquid chromatographic column containing 3% OV-210. Sensitivity of detection is in the nanogram range.

Interpretation of Linear Carrier Gas Velocity in Gas Chromatography.

1964 ◽  
Vol 36 (3) ◽  
pp. 693-695 ◽  
Author(s):  
P. C. van Berge ◽  
Victor. Pretorius
Keyword(s):  
Gas Chromatography ◽  
Gas Velocity ◽  
Carrier Gas ◽  
Carrier Gas Velocity
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