scholarly journals Structural alterations in lecithin-cholesterol vesicles following interactions with monomeric and micellar bile salts: physical-chemical basis for subselection of biliary lecithin species and aggregative states of biliary lipids during bile formation.

1990 ◽  
Vol 31 (1) ◽  
pp. 55-70
Author(s):  
DE Cohen ◽  
M Angelico ◽  
MC Carey
Keyword(s):  
Bile Salts ◽  
Bile Formation ◽  
Structural Alterations ◽  
Biliary Lipids ◽  
Chemical Basis ◽  
Physical Chemical

Effects of hypertonic solutions on bile formation

1963 ◽  
Vol 205 (5) ◽  
pp. 863-867 ◽  
Author(s):  
J. Chenderovitch ◽  
E. Phocas ◽  
M. Rautureau
Keyword(s):  
Guinea Pig ◽  
Bile Acids ◽  
Bile Salts ◽  
Jugular Vein ◽  
Osmotic Gradient ◽  
Bile Formation ◽  
Quantitative Formation ◽  
Hypertonic Solutions ◽  
Different Types

Modifications of flow and composition of bile have been studied in the guinea pig with ligated ureters after injection of hypertonic solutions of two nonmetabolizable substances, mannitol and xylose (1.66 m), into the jugular vein. A distinct and persistent decrease in biliary flow always occurs. Analysis of this anticholeresis showed a parallel decrease in the flow of water and electrolytes, while the flow of bilirubin and bile acids is not modified. There are, then, two different types of mechanisms in the formation of bile: the osmotic mechanisms which control the quantity of water and electrolytes; and the active secretory mechanisms, independent of the first, for specific substances such as bilirubin and bile salts. Ultrafiltration does not occur in quantitative formation of bile, but the bile/blood osmotic gradient plays an important role.

scholarly journals Membranes and bile formation. Composition of several mammalian biles and their membrane-damaging properties

1979 ◽  
Vol 178 (1) ◽  
pp. 201-208 ◽  
Author(s):  
R Coleman ◽  
S Iqbal ◽  
P P Godfrey ◽  
D Billington
Keyword(s):  
Guinea Pig ◽  
Bile Salts ◽  
Cell Damage ◽  
Membrane Damage ◽  
Total Content ◽  
Hepatic Cell ◽  
Membrane Composition ◽  
Bile Formation ◽  
Composition And Structure ◽  
High Concentrations

The total content and profile of bile salts and phospholipids are reported for several mammalian biles. Rabbit and guinea-pig biles are characterized by high proportions of conjugated dihydroxy bile salts with respect to trihydroxy bile salts, but contain relatively little phospholipid. Both rabbit and guinea-pig biles exhibit little evidence of hepatic cell damage, even though they are able to cause membrane damage (as evidenced by lysis of human erythrocytes) at low (2–3 mM) concentrations of bile salts; this lytic behaviour is also a property of their predominant bile salts. Addition of phosphatidylcholine to the bile or bile salt is able to decrease the lytic behaviour. Perhaps the most significant observation is that these biles, and their predominant bile salts, are dramatically less lytic towards sheep erythrocytes, indicating that some factor(s) in membrane composition and structure may partly explain the resistance of membranes of the biliary tract to the presence of high concentrations of potentially membrane-damaging bile salts.

Physical-Chemical Basis of Lipid Deposition in Atherosclerosis

Science ◽  
1974 ◽  
Vol 185 (4147) ◽  
pp. 222-229 ◽  
Author(s):  
D. M. Small ◽  
G. G. Shipley
Keyword(s):  
Lipid Deposition ◽  
Chemical Basis ◽  
Physical Chemical

Physical-Chemical Basis of Gallstone Formation

1991 ◽  
Vol 20 (1) ◽  
pp. 47-66
Author(s):  
Joanne M. Donovan ◽  
Martin C. Carey
Keyword(s):  
Gallstone Formation ◽  
Chemical Basis ◽  
Physical Chemical

Effects of bile salts on bile formation in rabbits

Life Sciences ◽  
1986 ◽  
Vol 38 (22) ◽  
pp. 2053-2061
Author(s):  
K. Miyasaka ◽  
K. Kitani
Keyword(s):  
Bile Salts ◽  
Bile Formation
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