The effects of magnesium ions on the fine structure of the insect neuromuscular junction

1978 ◽  
Vol 62 (2) ◽  
pp. 83-93 ◽  
Author(s):  
Roderick G. McKinlay ◽  
Peter N.R. Usherwood
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction ◽  
Magnesium Ions

scholarly journals In vivo recovery of muscle contraction after alpha-bungarotoxin binding.

1975 ◽  
Vol 66 (1) ◽  
pp. 209-213 ◽  
Author(s):  
H C Fertuck ◽  
W Woodward ◽  
M M Salpeter
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction ◽  
Muscle Contraction ◽  
Acetylcholine Receptors ◽  
Actinomycin D ◽  
Recovery Period ◽  
Em Autoradiography ◽  
Alpha Bungarotoxin ◽  
In Vivo Recovery

Acetylcholine receptors were inactivated in vivo at the mouse neuromuscular junction using alpha-bungarotoxin (alpha-BTX). It was found that neurally produced muscle contraction recovered within 4-8 days (halftime similar to 3 days). Actinomycin D interfered with this recovery, but did not affect normal nerve-stimulated muscle contraction. If the response was initially eliminated by [125-I]alpha-BTX and the end plates examined by EM autoradiography, no evidence of mass internalization of bound radioactivity during recovery was seen. The fine structure of the end plates and muscle was unaltered during the post-alpha-BTX recovery period.

THE FINE STRUCTURE OF THE MYASTHENIC NEUROMUSCULAR JUNCTION

1962 ◽  
Vol 21 (3) ◽  
pp. 335-347 ◽  
Author(s):  
S. I. ZACKS ◽  
W. C. BAUER ◽  
J. M. BLUMBERG
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction

Abnormalities in the Fine Structure of the Neuromuscular Junction in Patients with Myasthenia Gravis

Nature ◽  
1961 ◽  
Vol 190 (4772) ◽  
pp. 280-281 ◽  
Author(s):  
S. I. ZACKS ◽  
W. C. BAUER ◽  
J. M. BLTJMBEBG
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction ◽  
Myasthenia Gravis

Effect of colchicine on the fine structure of the neuromuscular junction

1972 ◽  
Vol 135 (4) ◽  
pp. 439-448 ◽  
Author(s):  
L. Hsu ◽  
Thomas L. Lentz
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction

The effects of taipoxin and notexin on the function and fine structure of the murine neuromuscular junction

Neuroscience ◽  
1976 ◽  
Vol 1 (3) ◽  
pp. 175-180 ◽  
Author(s):  
S.G. Cull-Candy ◽  
J. Fohlman ◽  
D. Gustavsson ◽  
Renate Lüllmann-Rauch ◽  
S. Thesleff
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction

scholarly journals OBSERVATIONS ON THE FINE STRUCTURE AND CYTOCHEMISTRY OF MOUSE AND HUMAN INTERCOSTAL NEUROMUSCULAR JUNCTIONS

1961 ◽  
Vol 10 (4) ◽  
pp. 517-528 ◽  
Author(s):  
S. I. Zacks ◽  
J. M. Blumberg
Keyword(s):  
Fine Structure ◽  
Neuromuscular Junction ◽  
Neuromuscular Junctions ◽  
Surface Membrane ◽  
Basement Membranes ◽  
Intercostal Muscle ◽  
Motor End Plates ◽  
Thin Plastic ◽  
Subneural Apparatus ◽  
Amorphous Surface

The fine structure of the mouse and human intercostal muscle neuromuscular junction was studied after brief fixation in a new formol-sucrose fixative. This primary formalin fixation was followed by brief postosmication in buffered 1 per cent osmium tetroxide. Muscle blocks were embedded in methacrylate or Epon 812 epoxy resin. Marked similarities between mouse and human motor end-plates were observed. Neuromuscular junctions from both mouse and human intercostal muscle showed synaptic vesicles, primary and secondary synaptic clefts, and layered differentiation of the amorphous surface material (ASM) present on the surface of the Schwann cell plasma membrane and on the muscle surface membrane in the region of the neuromuscular junction. An attempt to stain the ASM with lead was unsuccessful. Observations on thick and thin plastic-embedded sections stained by PAS after diastase digestion showed that the ASM within the subneural apparatus is PAS positive. Alcian blue stained the endoneurium and perineurium of peripheral nerve bundles and portions of the end-plates. The similarity of the PAS-positive ASM to other basement membranes described in other sites is discussed and its possible physiologic significance within the subsynaptic apparatus is considered.

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