Calcium channel antagonists in the management of anginal syndromes: Changing concepts in relation to the role of coronary vasospasm

1996 ◽  
Vol 38 (4) ◽  
pp. 291-314 ◽  
Author(s):  
Lionel H. Opie
Keyword(s):  
Calcium Channel ◽  
Coronary Vasospasm ◽  
Calcium Channel Antagonists

Defining the Role of Calcium Channel Antagonists in Heart Failure Due to Systolic Dysfunction

2003 ◽  
Vol 3 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Isabelle Mah?? ◽  
Olivier Chassany ◽  
Anne-Sophie Grenard ◽  
Charles Caulin ◽  
Jean-Fran??ois Bergmann
Keyword(s):  
Heart Failure ◽  
Calcium Channel ◽  
Systolic Dysfunction ◽  
Calcium Channel Antagonists

The Role of Thrombolysis and Calcium Channel Antagonists in the Treatment of Acute Cerebrovascular Accident

1990 ◽  
Vol 5 (3) ◽  
pp. 261-264
Author(s):  
Kaveh Ikhanipour ◽  
Michael A. Turturro
Keyword(s):  
Calcium Channel ◽  
Lessons Learned ◽  
The Body ◽  
Calcium Channel Antagonists ◽  
Acute Cerebral Ischemia ◽  
Experimental Therapies ◽  
Hypervolemic Hemodilution ◽  
Cerebrovascular Insult ◽  
The Brain

Therapy following an acute cerebrovascular insult traditionally has focused on preserving function of the uninjured cerebral tissue. However, in recent years, interest has developed on the possibility of restoration of function to the injured areas of the brain. Lessons learned in reperfusion following acute myocardial infarction have raised newer questions about the utility of reperfusion to other areas of the body subjected to acute ischemic events. In addition, studies with acute cerebral ischemia have suggested that calcium channel antagonists improve outcome, either by decreasing cerebral vasospasm, offering neuronal protection by inhibiting the formation of toxic metabolites in the injured neurons, or by some combination of these two mechanisms. Other experimental therapies, such as the use of hypervolemic hemodilution, attempt to restore cerebral blood flow following an acute vasospasmic or thromboembolic event. As these new therapies develop, we will see a major emphasis on restoring cerebral function following acute stroke.

Calcium-Channel Antagonists for Prevention of Atherosclerosis

1993 ◽  
Vol 27 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Shawn M. Borcherding ◽  
Suzanne G. Meeves ◽  
Neil E. Klutman ◽  
Patricia A. Howard
Keyword(s):  
Clinical Trials ◽  
Calcium Channel ◽  
Calcium Antagonists ◽  
Clinical Studies ◽  
Animal Studies ◽  
English Language ◽  
Data Extraction ◽  
Calcium Channel Antagonists ◽  
Trial Duration

OBJECTIVE: To critically evaluate the current literature regarding the role of calcium-channel antagonists in preventing atherosclerosis. DATA SOURCES: English language clinical studies, abstracts, conference proceedings, and review articles pertaining to calcium-channel antagonists and atherosclerosis. STUDY SELECTION: Relevant animal and human studies examining the role of calcium-channel antagonists in atherosclerosis prevention and treatment. DATA EXTRACTION: Potential mechanisms for the development of atherosclerosis and the use of calcium antagonists for preventing and treating coronary artery disease are discussed. Animal studies are summarized; next, significant data from human clinical studies are presented. DATA SYNTHESIS: Available studies are described and discussed. CONCLUSIONS: Results from animal and clinical trials in humans suggest that calcium antagonists may retard the development and progression of atherosclerosis. However, most clinical trials to date have been conducted in patients with proven atherosclerotic plaques. Further studies examining the role of calcium-channel antagonists in preventing and treating atherosclerosis are needed, but may be difficult to conduct because of the large numbers of patients required, long trial duration, and associated costs.

Crystal structure analysis of 4-R-phenyl-2,6-dimethyl-3,5-N-(dimethylcarbamoyl)-1,4-dihydropyridines [R=2-nitro (1), 4-methoxy (2) and 3,4-dichloro (3)]

1998 ◽  
Vol 213 (3) ◽  
Author(s):  
M. Bidya Sagar ◽  
K. Ravikumar ◽  
Y. S. Sadanandam
Keyword(s):  
Crystal Structure ◽  
Calcium Channel ◽  
Structure Analysis ◽  
Crystal Structure Analysis ◽  
Calcium Channel Antagonists

AbstractThe crystallographic characterization of the following three calcium channel antagonists is reported here: 2,6-dimethyl-3,5-dicarbamoyl-4-[2-nitro]-1,4-dihydropyridine (

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