An efficient synthesis of furyl sulfonamides from the reaction of furan with in situ generated N-tosyl imines

Tetrahedron ◽  
2003 ◽  
Vol 59 (27) ◽  
pp. 4939-4944 ◽  
Author(s):  
Albert Padwa ◽  
Atsuhiku Zanka ◽  
Michael P. Cassidy ◽  
Joel M. Harris
Keyword(s):  
Efficient Synthesis

scholarly journals Indium-Catalyzed Direct Conversion of Lactones into Thiolactones Using a Disilathiane as a Sulfur Source

2018 ◽  
Author(s):  
Yohei Ogiwara ◽  
Ken Takano ◽  
Shuhei Horikawa ◽  
Norio Sakai
Keyword(s):  
Elemental Sulfur ◽  
Direct Conversion ◽  
Pharmaceutical Chemistry ◽  
Sulfur Source ◽  
Efficient Synthesis ◽  
Previous Reaction ◽  
Indium Catalyst

Indium-catalyzed reaction of lactones and a disilathiane leading to thiolactones is described. The direct synthesis of thiolactones from lactones with an appropriate sulfur source is one of the most attractive approaches in organic and pharmaceutical chemistry. In this context, we found an indium-catalyzed direct conversion of lactones into thiolactones in the presence of elemental sulfur and a hydrosilane via formation of the disilathiane in-situ. On the basis of the previous reaction, the application utilizing the disilathiane as a sulfur source was performed herein for the efficient synthesis of a variety of thiolactone derivatives from lactones by an indium-catalyst.

Efficient Synthesis of Diospyrol via Suzuki-Miyaura and Modified in situ Cross-Coupling

Synthesis ◽  
2005 ◽  
Vol 2005 (17) ◽  
pp. 2934-2938
Author(s):  
Somsak Ruchirawat ◽  
Poolsak Sahakitpichan ◽  
Nopporn Thasana
Keyword(s):  
Cross Coupling ◽  
Efficient Synthesis

scholarly journals Efficient synthesis of ponasterone A by recombinant Escherichia coli harboring the glycosyltransferase GTBP1with in situ product removal

RSC Advances ◽  
2017 ◽  
Vol 7 (37) ◽  
pp. 23027-23029 ◽  
Author(s):  
Bingfeng Li ◽  
Xuejun He ◽  
Bo Fan ◽  
Jianlin Chu ◽  
Bingfang He
Keyword(s):  
Escherichia Coli ◽  
Bacillus Pumilus ◽  
Recombinant Escherichia Coli ◽  
Efficient Synthesis ◽  
In Situ Product Removal ◽  
Product Removal ◽  
Ponasterone A

A glycosyltransferase GTBP1fromBacillus pumilusBF1 was isolated.

Efficient synthesis of 1,2,4-oxadiazine-5-ones via [3+3] cycloaddition of in situ generated aza-oxyallylic cations with nitrile oxides

2018 ◽  
Vol 59 (21) ◽  
pp. 2018-2020 ◽  
Author(s):  
Gangqiang Wang ◽  
Rongxing Chen ◽  
Sen Zhao ◽  
Liangfeng Yang ◽  
Haibing Guo ◽  
...  
Keyword(s):  
Efficient Synthesis ◽  
Nitrile Oxides

Oxidative Cyclization of β,γ-Unsaturated Carboxylic Acids Using Hypervalent Iodine Reagents: An Efficient Synthesis of 4-Substituted Furan-2-ones

Synthesis ◽  
2017 ◽  
Vol 49 (13) ◽  
pp. 2907-2912 ◽  
Author(s):  
Kensuke Kiyokawa ◽  
Satoshi Minakata ◽  
Kenta Takemoto ◽  
Shunsuke Yahata ◽  
Takumi Kojima
Keyword(s):  
Organic Chemistry ◽  
Carboxylic Acids ◽  
Present Method ◽  
Medicinal Chemistry ◽  
Oxidative Cyclization ◽  
Hypervalent Iodine ◽  
Efficient Synthesis ◽  
Substitution Pattern ◽  
Unsaturated Carboxylic Acids

The oxidative cyclization of β-substituted β,γ-unsaturated carboxylic acids using a hypervalent iodine reagent to provide 4-substituted furan-2-one products, is reported. In this cyclization, the use of a highly electrophilic PhI(OTf)2, which is in situ prepared from PhI(OAc)2 and Me3SiOTf, is crucial. Depending on the substitution pattern at the α-position of the substrates, furan-2(5H)-ones or furan-2(3H)-ones are produced. Thus, the present method offers a useful tool for accessing various types of 4-substituted furan-2-ones that are important structural motifs in the field of organic chemistry and medicinal chemistry.

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